全踝关节镜手术治疗陈旧性外踝撕脱骨折并发踝关节不稳的疗效观察

目的:探讨全踝关节镜手术治疗陈旧性外踝撕脱骨折并发踝关节不稳的临床疗效及可行性。方法:回顾性分析。纳入2017年1月—2019年1月徐州市中心医院骨科陈旧性外踝撕脱骨折并发踝关节不稳患者21例(21足),其中男12例、女9例,年龄16～63 (31.34±12.17)岁,右侧13例、左侧8例。21足均采用全踝关节镜下修...     

The efficacy and safety of treatments for infantile hemangiomas: a Bayesian network meta-analysis

Whether infantile hemangiomas (IHs) need to be treated and which treatment should be preferred are still controversial. We aimed to compare and rank the treatments and identify the optimal treatment for IHs. We searched PubMed, EMBASE, the Cochrane Library, Web of Science, and other sources for randomized controlled trials up to August 2019. We included trials comparingdifferent treatments and reported response or adverse events rate in IH patients. Two reviewers independently evaluated studies by specific criteria and extracted data. We assessed the risk of bias with the Cochrane risk of bias tool. Random-effects were performed for pair-to-pair and Bayesian framework network meta-analyses. The primary outcomes were efficacy and safety. We deemed 20 studies eligible, including 1149 participants and eight interventions. For efficacy, oral propranolol and topical propranolol/timolol were better than observation/placebo (OR, 95% CrI: 17.05, 4.02–94.94; 9.72, 1.91–59.08). For safety, topical propranolol/timolol was significantly better tolerated than oral propranolol (0.05, 0.001–0.66). Cluster analysis demonstrated oral propranolol was the most effective treatment for IHs, while topical propranolol/timolol showed high efficacy and the highest safety. Laser, intralesional propranolol or glucocorticoid, oral glucocorticoid, or captopril had significantly lower priority than oral propranolol or topical propranolol/timolol considering both efficacy and safety. The quality of evidence was rated as moderate or low in most comparisons. This network meta-analysis found topical beta-blockers had the potential to be the most preferable and beneficial option for IHs in consideration of both efficacy and safety.     

Listeria rhombencephalitis mimicking acute disseminated encephalomyelitis in a patient without predisposing medical conditions

Journal of NeuroVirology - Listeria rhombencephalitis (L. rhombencephalitis) is an uncommon form of central nervous system infection caused by Listeria monocytogenes (LM). It often occurs to...     

Iris Segmentation Using Feature Channel Optimization for Noisy Environments

In recent years, iris recognition has been widely used in various fields. As the first step of iris recognition, segmentation accuracy is of great significance to the final recognition. However, iris images exhibit a variety of noise in the real world, which leads to lower segmentation accuracy than the ideal case. To address this problem, this paper proposes an iris segmentation method using feature channel optimization for noisy images. The method for non-ideal environments with noise is more suitable for practical applications. We add dense blocks and dilated convolutional layers to the encoder so that the information gradient flow obtained by different layers can be reused, and the receptive field can be expanded. In the decoder, based on Jensen-Shannon (JS) divergence, we first recalculate the weight of the feature channels obtained from each layer, which enhances the useful information and suppresses the interference information in the noisy environments to boost the segmentation accuracy. The proposed architecture is validated in the CASIA v4.0 interval (CASIA) and IIT Delhi v1.0 datasets (IITD). For CASIA, the mean error rate is 0.78%, and the F-measure value is 98.21%. For IITD, the mean error rate is 0.97%, and the F-measure value is 97.87%. Experimental results show that the proposed method outperforms other state-of-art methods under noisy environments, such as Gaussian blur, Gaussian noise, and salt and pepper noise.

     

Aluminum-induced “mixed” cell death in mice cerebral tissue and potential intervention

Neurotoxicity Research - The brain is one of organs vulnerable to aluminum insult. Aluminum toxicity is involved in neurobehavioral deficit, neuronal cell dysfunction, and death. The aim of this...     

放疗联合安罗替尼对小细胞肺癌患者胱天蛋白酶3、多腺苷二磷酸核糖聚合酶表达的影响研究

目的探讨放疗联合安罗替尼对小细胞肺癌(SCLC)患者胱天蛋白酶3(caspase 3)、多腺苷二磷酸核糖聚合酶(PARP)表达的影响。方法将86例SCLC患者随机分为放疗组(n=42)和联合组(放疗联合安罗替尼,n=44),探索两组1年生存率、不良反应发生情况及对caspase 3、PARP表达的影响。结果治疗前两组患者血清caspase 3、PARP水平比较,差异均无统计学意义(P﹥0.05);治疗后联合组患者血清caspase 3水平明显高于放疗组,PARP水平明显低于放疗组,差异均有统计学意义(P﹤0.01)。两组患者白细胞减少、中性粒细胞减少发生率比较,差异均无统计学意义(P﹥0.05)。联合组患者1年生存率高于放疗组,差异有统计学意义(P﹤0.05)。结论放疗联合安罗替尼可以有效提高SCLC患者血清内caspase 3水平,降低PARP水平,延长患者的生存时间,值得临床进一步研究。