肾集合管癌的CT诊断(2例报道并文献复习)

目的:探讨肾集合管癌的CT表现,以加深对肾集合管癌的认识,提高肾集合管癌CT诊断的准确性.方法:结合相关文献,回顾性分析两例病理确诊的肾脏集合管癌病人的临床及CT影像资料.结果:病例1 CT表现为:左肾上极一低密度病灶,边界不清,最大层面约70 mm×62 mm,其内多发钙化灶,增强后病灶轻度强化;另见左肾门旁淋巴结肿大,最大直径约24 mm,增强后环形强化.病例2 CT表现为:右肾下极一低密度灶,边界不清,最大层面约53 mm×48 mm,其内多发钙化灶,增强三期病灶CT值稍有变化,考虑病灶有轻度强化,另见多发腹膜后淋巴结肿大,最大直径约30 mm.结论:肾集合管癌的CT表现有一定的特征性,充分认识到这些特征性有助于提高该病的CT诊断准确性.     

业务流程再造理论对优化门诊药房工作的影响

目的 探讨业务流程再造理论优化门诊药房工作的意义及影响.方法 随机选取本院再造前2012年1～6月门诊患者60例为对照组,改造后2013年1～6月的60例患者为实验组,比较两组患者的取药时间及对门诊流程再造的满意度,并对两个时期门诊药房医师处理药方的数量和时间进行比较.结果 实验组的等待时间、取药时间明显短于对照组,满意度明显高于对照组,差异有统计学意义(P＜0.05).实验组门诊医师每小时平均处理处方量明显多于对照组,每方调配时间短于对照组,差异有统计学意义(P＜0.05).结论 业务流程再造理论具有较高的临床应用价值,值得各医院门诊药房进一步应用.     

静脉用丙种球蛋白辅助治疗小儿重症腺病毒肺炎的临床效果

目的 探讨静脉用丙种球蛋白辅助治疗小儿重症腺病毒肺炎的临床效果.方法 收集本院儿科病房2014年1～9月共80例诊断为重症腺病毒肺炎的儿童为研究对象,按随机数字表法分为研究组和对照组各40例.两组患者均予抗病毒和(或)抗生素治疗以及对症治疗,研究组在上述治疗基础上加用丙种球蛋白.比较两组的机械通气时间、住院期间并发症发生率及临床疗效.结果 研究组机械通气时间短于对照组、住院期间并发症发生率低于对照组、治疗总有效率高于对照组,差异有统计学意义(P＜0.05).结论 丙种球蛋白配合抗病毒治疗重症腺病毒肺炎不仅可缩短机械通气时间,减少并发症的发生,还可提高治疗效果.     

复发性流产妊娠结局的相关因素分析

目的：研究复发性流产(RSA)妊娠结局的相关因素。方法回顾性分析2012年3月~2014年2月在本站与广州医学院第二附属医院就诊的120例RSA妊娠患者的临床资料,统计并分析RSA妊娠结局的相关因素。结果120例RSA患者中27例妊娠失败,失败率为22.50豫;年龄、就诊时孕周、HOMA-IR、孕前有调理、流产次数>3次、内分泌异常、抗精子抗体阳性、抗心磷脂抗体阳性等对妊娠结局有重要影响(P<0.05);年龄、就诊时孕周、抗心磷脂抗体阳性为妊娠结局失败的独立危险因素(P<0.05)。结论控制RSA妊娠结局的相关因素,尤其是妊娠结局失败的独立危险因素,可有效降低妊娠结局的失败率。     

提高医学院校文科生生物化学教学质量策略探讨

生物化学是医学院校学生一门重要的公共基础课。大多数学生认为生物化学这门课程内容庞杂、名词术语繁多、抽象难懂、学习难度大,尤其对于生物学科与化学学科基础薄弱的文科生来讲,学习过程吃力,学习效果不理想,期末挂科率较高。本研究从文科生学习生物化学遇到的困难及教师面临的教学现状出发,找出问题,探讨具体应对策略,旨在提高学生学习生物化学课的兴趣和效果。     

电针少阳经穴对急性偏头痛即时镇痛作用时效规律研究

目的:观察少阳经循经取穴与非经非穴电针治疗急性偏头痛即时镇痛效应及时效性差异。方法:采用随机对照试验方法,将110例急性偏头痛患者随机分为两组,每组55例。观察组取少阳经经穴风池、外关等电针治疗,对照组采用非经非穴电针治疗,两组均治疗1次,留针30min。在电针前、电针后5min、10min、20min、30min(起针后即刻)、1h、2h、4h、6h、8h的镇痛效果。采用11点疼痛强度数字等级量表(NRS)对患者的疼痛程度进行评分,并记录不良反应。结果:1观察组即时镇痛有效率为87.3%(48/55),显著高于对照组的52.7%(29/55,P<0.01);2观察组及对照组患者电针后5min开始至电针后8h各时间点NRS均降低(均P<0.01);3电针后不同时间点NRS评分比较,30min时对照组明显低于观察组(P<0.05),但是2h、4h、6h及8h时观察组明显低于对照组(均P<0.01),5min、10min、20min及1h时间点两组间差异无统计学意义(均P>0.05);4电针后同时间点NRS减值幅度,电针后20 min、30min及1h时对照组明显高于观察组(均P<0.05),但是电针后2h、4h、6h及8h时观察组明显高于对照组(均P<0.05),5 min及10min时差异无统计学意义(均P>0.05);5电针后24h观察组偏头痛复发率为12.7%(7/55),明显低于对照组的34.5%(19/55,P<0.05);6两组均未出现不良反应。结论:电针少阳经穴对急性期偏头痛具有肯定的即时镇痛效应,与电针非经非穴比较镇痛作用更强且持久。     

胎停育相关影响因素研究

目的本研究通过分析胎停育夫妻静脉血重金属及微量元素含量以及生活、环境有关因素,探讨与胎停育发生有关的原因,为今后采取相应的预防措施、提高妇女优生优育比例奠定基础。方法选择2010年2月-2013年12月,在某院妇产科就诊或接受产前检查的孕产妇作为研究对象,将临床检查及B超辅助诊断确诊为胚胎停止发育、自然流产的夫妻84对作为观察组;将同时期在该院接受产检至分娩且新生儿无异常的夫妻84对作为对照组。采用原子吸收分光光度计法检测患者静脉血中锌、铜、铅的元素的含量,并采用自行设计的问卷比较2组差异。结果女性观察组与对照组比较,血锌的含量差异有统计学意义,观察组血锌水平低于对照组(t=17.18,P<0.01)。血铅水平有差异,观察组血铅水平高于对照组(t=15.74,P<0.01)。结论女性孕期血液中微量元素及配偶血液中重金属水平与胎停育的发生具有相关性,应加强孕前宣传,普及孕前检查及孕前医学咨询,避免接触有害因素,从而提高优生优育的比例。     

头孢哌酮/舒巴坦治疗耐药菌与二重感染患者的疗效评价

目的研究应用头孢哌酮/舒巴坦治疗耐药菌及二重感染患者进行的临床效果。方法回顾性分析2012年9月-2013年9月应用头孢哌酮/舒巴坦进行治疗的294例耐药菌感染患者及二重感染患者临床资料,采用SPSS 19.0软件进行统计处理。结果共培养出336株病原菌,革兰阴性菌267株占79.46%,革兰阳性菌69株占20.54%;革兰阴性菌对头孢哌酮/舒巴坦敏感率达79.78%;革兰阳性菌对头孢哌酮/舒巴坦敏感率达82.61%;127例二重感染患者培养出病原菌201株,均为革兰阴性菌,其对头孢哌酮/舒巴坦敏感率达80.10%。结论应用头孢哌酮/舒巴坦对耐药菌及二重感染患者进行治疗,效果显著。     

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??OBJECTIVE To study the endophytic fungi in the seeds of Gardenia from different regions, identy the strains carried by the seed surface and interior, and compare the treatment effects of different fungicides, to provide reference for the antibacterial treatment before gardenia seed sowing and fungal disease control. METHODS Plate method was used for the surface and internal detection of Gardenia seeds from 15 countries in China, method of seed dressing was used for seed treatment and disinfection effects of 6 kinds of fungicides is done. RESULTS Main flora in surface of the seed are genus Fusarium, Mucor, Penicillium, Aspergillus and Rhizopus, Penicillium and Aspergillus are the dominant species. There is no significant difference in this 5 species of the seeds from different places, but significant difference in isolation frequency. Load capacity of the spore range from (6.7 ?? 11.5) to (1 333.3 ?? 230.1) per seed .There is significant difference in spore load from different places. Endophytic fungi inside the seeds are mainly Aspergillus, Penicillium, Mucor, Rhizopus and etc. There is significant difference in seeds of these fungi, it ranges from (1.7??2.9)% to (58.3??17.6)%. Carrier rate and species of fungal among different habitats are significantly different, discrete frequency of Aspergillus is the highest. CONCLUSION The six antiseptics provided all have kill and inhibition to Gardenia seed fungus in some extent. Bactericidal effects of carbendazim fernasan and carbendazim are the poorest, and fernasan ziram and oxadixyl mancozeb and evil frost are the best, which can achieve above 95.0%. Suggestion is made to choose fernasan ziram and oxadixyl mancozeb as inhibiting fungus agents of Gardenia seed disinfection treatment.     

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??OBJECTIVE To evaluate the safety and tolerability of baicalein chewable tablets and establish the maximum tolerated dose in healthy volunteers. METHODS A randomized, double-blind, dose-escalating, single-center, phase I clinical trial was conducted in 70 healthy male and female subjects. Each subject received oral baicalein only once. Adverse events were identified either by subject self-reporting or evaluation based upon vital signs, physical examination and laboratory parameters. The study was conducted from low to high dose, and the dose escalation was performed only after the safety and tolerability were confirmed favorable. RESULTS Baicalein chewable tablets were well tolerated and had an acceptable safety profile up to the highest dose of 2 800 mg. The vital signs of all subjects were stable, and no QTc interval prolongation was observed during the trial. A total of 11 mild adverse events were reported in 8 subjects. There were no severe adverse events in the study, and none of the adverse events led to withdrawal. CONCLUSION This study suggests that the innovative drug baicalein chewable tablets are well tolerated in healthy Chinese volunteers within the dose range of 100 to 2 800 mg.