全文获取类型
收费全文 | 69249篇 |
免费 | 6413篇 |
国内免费 | 5056篇 |
专业分类
耳鼻咽喉 | 406篇 |
儿科学 | 719篇 |
妇产科学 | 876篇 |
基础医学 | 8714篇 |
口腔科学 | 1195篇 |
临床医学 | 9295篇 |
内科学 | 10575篇 |
皮肤病学 | 767篇 |
神经病学 | 3647篇 |
特种医学 | 2416篇 |
外国民族医学 | 41篇 |
外科学 | 7080篇 |
综合类 | 11981篇 |
现状与发展 | 17篇 |
一般理论 | 2篇 |
预防医学 | 4261篇 |
眼科学 | 1825篇 |
药学 | 7376篇 |
75篇 | |
中国医学 | 3673篇 |
肿瘤学 | 5777篇 |
出版年
2024年 | 224篇 |
2023年 | 1201篇 |
2022年 | 2857篇 |
2021年 | 3591篇 |
2020年 | 2606篇 |
2019年 | 2362篇 |
2018年 | 2390篇 |
2017年 | 2050篇 |
2016年 | 2059篇 |
2015年 | 3139篇 |
2014年 | 3946篇 |
2013年 | 3268篇 |
2012年 | 4795篇 |
2011年 | 5671篇 |
2010年 | 3276篇 |
2009年 | 2486篇 |
2008年 | 3436篇 |
2007年 | 3520篇 |
2006年 | 3607篇 |
2005年 | 3448篇 |
2004年 | 2237篇 |
2003年 | 2201篇 |
2002年 | 1834篇 |
2001年 | 1694篇 |
2000年 | 1775篇 |
1999年 | 1969篇 |
1998年 | 1253篇 |
1997年 | 1345篇 |
1996年 | 1009篇 |
1995年 | 888篇 |
1994年 | 768篇 |
1993年 | 488篇 |
1992年 | 602篇 |
1991年 | 521篇 |
1990年 | 447篇 |
1989年 | 394篇 |
1988年 | 325篇 |
1987年 | 283篇 |
1986年 | 249篇 |
1985年 | 173篇 |
1984年 | 102篇 |
1983年 | 72篇 |
1982年 | 38篇 |
1981年 | 52篇 |
1980年 | 28篇 |
1979年 | 38篇 |
1963年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Kathleen M Egan Qiuyin Cai Xiao-Ou Shu Fan Jin Tian-Li Zhu Qi Dai Yu-Tang Gao Wei Zheng 《Cancer epidemiology, biomarkers & prevention》2004,13(2):197-204
PURPOSE: We studied the relation of breast cancer to common deletion mutations in GSTM1 and GSTT1 and the functional Ile(105)Val polymorphism in GSTP1 in a large, population-based case-control study conducted in China and performed a meta-analysis to summarize the literature. EXPERIMENTAL DESIGN: In the case-control study, a total of 1144 breast cancer cases and 1221 community controls were genotyped for GSTM1, GSTP1, and GSTT1 using PCR-based methods. Associations of genotypes and breast cancer were evaluated in logistic regression models. Meta-analysis odds ratios (ORs) were estimated using a fixed effects model. RESULTS: In the case-control study, associations were null for GSTM1 [age-adjusted OR 0.97, 95% confidence interval (CI): 0.82-1.14] and GSTT1 (OR 0.97, 95% CI: 0.83-1.15). A significant increase in risk was observed among homozygotes for the variant Ile(105)Val polymorphism (OR 1.92, 95% CI: 1.21-3.04). No combined effects of GSTM1, GSTP1, and GSTT1 genotypes or interactions with potential effect modifiers were detected. All results were similar in pre- and postmenopausal women and for early versus advanced stage breast cancer. The meta-analysis, based predominantly on Caucasian women, supported null results for the homozygous deletion variant in GSTM1 (summary OR 1.05; combining 19 studies) and GSTT1 (summary OR 1.11; 15 studies). Meta-analysis results for the homozygous GSTP1 variant indicated no overall association (summary OR 1.04; 10 studies), although results varied significantly across studies (P = 0.009). CONCLUSIONS: This large case-control study provides strong support for earlier studies showing no overall association of the GSTM1 and GSTT1 deletion polymorphisms with breast cancer risk. The GSTP1 variant may be relevant to breast cancer risk in Asian populations. 相似文献
992.
993.
ZHUXue-qiong SHIYi-fu CHENXiao-duan WUYu-zhong 《中国癌症研究》2004,16(2):142-146
Objective: To evaluate the diagnostic implications of immunohistochemieal markers in uterine smooth muscle tumors. Methods: Formalin-fixed paraffin-embedded tissue blocks were selected from 17 uterine leiomyosarcomas, 40 uterine unusual leiomyomas and 25 uterine usual leiomyomas. Utilizing immunohistochemical techniques with antigen retrieval, serial sections of each tumor for immunoreactivity with myogenic markers, ovarian steroid receptors, CD44v3, proliferating cell nuclear antigen and mast cells were assessed. Results: Although the myogenic markers and CD44v3 showed less frequent positivity in uterine leiomyosarcomas than those in unusual leiomyomas,they were not reliable markers for differentiating leiomyosarcoma from leiomyoma. Uterine leiomyosarcoma tended to have lower ovarian steroid receptors immunoreactivity rates than leiomyoma. Leiomyoma tended to have a higher quantity of intratumoral mast cells than leiomyosarcoma, while the expression of proliferating cell nuclear antigen was lower in them. Conclusion: Because the estimation of mitotic count was subject to significant variation, the immunohistochemical expression of ovarian steroid receptors, mast cells and proliferating cell nuclear antigen seemed to be helpful for the discrimination of unusual leiomyoma from leiomyosarcoma. 相似文献
994.
ICAM-1 deficiency suppresses host allosensitization and rejection of MHC-disparate corneal transplants 总被引:6,自引:0,他引:6
BACKGROUND: We used a murine model of orthotopic corneal transplantation to determine whether host deficiency in ICAM-1 promotes survival of corneal grafts with different degrees of allodisparity. METHODS: ICAM-1-/- and wild-type C57BL/6 (ICAM-1+/+) received corneal grafts from the following strains of mice: BALB/c (fully mismatched), BALB.b (mismatched at multiple minor H only), or B10.D2 [including major histocompatibility complex (MHC) mismatch]. Graft rejection, induction of allospecific delayed-type hypersensitivity (DTH) responses, and leukocytic infiltration of grafts were measured. RESULTS: There were no differences in long-term survival of allografts that were either fully mismatched or had only minor H disparity in ICAM-1+/+ vs. ICAM-1-/-hosts. However, whereas B10.D2 grafts were accepted in only 58% of the ICAM-1+/+ hosts, graft survival in ICAM-1-/- recipients was 100% (P=0.006). Moreover, none of the ICAM-1-/- mice receiving B10.D2 grafts developed allospecific DTH. CONCLUSIONS: Prolonged survival seen in MHC-mismatched grafts in ICAM-1-/- mice, along with a suppressed DTH response to donor alloantigens after transplantation, suggest that ICAM-1 is associated with recipient sensitization to MHC alloantigens. 相似文献
995.
996.
997.
Zhu Wei-ping 《针灸推拿医学(英文版)》2003,1(6):24-25
Purpose: To observe the clinical therapeutic effect in the treatment of enuresis by ginger-partitioned moxibustion plus cupping therapy.Methods: Ginger-partitioned moxibustion was applied on Guanyuan (CV 4) and bilateral Zusanli (ST 36) and cupping therapy was applied
on Shenque (CV 8) in the treatment of 82 cases of enuresis, in comparison with 76 cases treated by Chinese herbal medicine.Results: The effective rate was 84.1% in the treatment by ginger-partitioned moxibustion plus cupping therapy and was 64.5% in the
treatment by Chinese herbal medicine.Conclusion: Ginger-partitioned moxibustion plus cupping therapy was better than Chinese herbal medicine in the treatment of enuresis
(P<0.05).
Translator: HUANG Guo-qi 相似文献
998.
999.
1000.
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. 总被引:27,自引:0,他引:27
Donghui Li Jijiang Zhu Pervez F Firozi James L Abbruzzese Douglas B Evans Karen Cleary Helmut Friess Subrata Sen 《Clinical cancer research》2003,9(3):991-997
PURPOSE: Multiple chromosome abnormalities, including gain of chromosome20q, have been detected frequently in human pancreatic cancers. Overexpression of the STK15/BTAK/Aurora A gene located on chromosome 20q13, which encodes a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation in multiple in vitro experimental systems. The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer. EXPERIMENTAL DESIGN: STK15 expression at both the mRNA and protein levels together with the copy number of STK15 gene was measured in nine pancreatic carcinoma cell lines: (a) HPAF-II; (b) Aspc-1; (c) Panc-1; (d) Panc-3; (e) Panc-28; (f) Panc-48; (g) HS766T; (h) MIAPaCa-2; and (i) BxPc3. STK15 protein expression was also examined in normal pancreatic tissues and tumors by Western blotting and immunohistochemistry. RESULTS: STK15 was overexpressed in all of the nine cell lines examined, but gene amplification was infrequent. Western Blot analysis of primary tumor tissues revealed 2-10 times overexpression of STK15 protein compared with normal adjacent tissues from pancreatic cancer patients. Concurrent overexpression of cdc20, an STK15-associated protein, and reduced expression of cdc25, a mitosis-activating protein phosphatase, were detected in the same tumor samples. Elevated STK15 protein expression was detected in 22 of 38 tumor sections (58%) from pancreatic cancer patients. The extent of STK15 expression was not significantly correlated with the size, degree of differentiation, and metastasis status of the tumors. CONCLUSIONS: These results show that STK15 is overexpressed in pancreatic tumors and carcinoma cell lines and suggest that overexpression of STK15 may play a role in pancreatic carcinogenesis. 相似文献