Modification of C.I. Pigment Red 146 with surfactants and graphene oxide

Organic pigments are important in a range of fields, from printing ink to industrial coatings. Azo pigments are some of the most common pigments in use today, but they typically have poor solvent solubility and tend to agglomerate. Consequently, the size and crystal structure of the pigment particles has a crucial effect on their optical and physical properties, such as color strength and solvent resistance, respectively. Several technologies, such as microreactors, have been developed to control pigment particle size, but an in-depth study of the effects of modification conditions on pigment properties (color, flowability, and solvent resistance) has not been reported to date. Therefore, in this paper, we report the surface modification of C.I. Pigment Red 146 particles using anionic (Igepon T) and non-ionic surfactants (Peregal O-25) and additives (DB-60 as the second diazo component and graphene oxide) on the pigment properties. In addition, we examined the effect of hydrothermal treatment at different temperatures on the same properties. The various modifications resulted in an increase in the solvent resistance, a reduction in the particle size (from 30.581 to 12.252 μm), a narrowing of the particle size distribution, and an increase in hydrophilicity. In addition, the color brightness and brilliance were significantly improved, and the maximum color strength reached 112.6%. These findings have applications for the development of pigments having enhanced color properties, solvent resistance, and processability.

The color properties and solvent resistance of modified Pigment Red 146 were obviously improved by adding surfactants and graphene oxide.     

幽门螺杆菌感染和胃液维生素C浓度关系研究

目的 研究幽门螺杆菌(Hp)感染和胃液中维生素C(VitC)浓度的关系,探讨Hp导致胃病的机制.方法 用高铁还原法测定胃液中VitC浓度,用尿素酶试验和病理Giemsa染色检测Hp.对部分Hp阳性患者进行Hp根除治疗,并比较其治疗前后胃液中VitC浓度的变化.结果 Hp阳性各实验组胃液中VitC浓度分别为:浅表性胃炎26.1 mg/L、萎缩性胃炎伴肠上皮化生13.4 mg/L,异型增生12.7 mg/L,与Hp阴性正常对照组35.2 mg/L比较差异均具有统计学意义(P＜0.05);Hp根除后其胃液中VitC浓度恢复正常,而Hp未根除者其胃液中VitC浓度无明显变化.结论 Hp感染可导致胃液中VitC浓度降低,这可能是Hp致病机制之一;根除Hp可以恢复胃液中VitC浓度,这有利于预防胃癌的发生.     

局部植入BMP对去势大鼠股骨近端生物力学强度及髓腔面积变化的影响

目的探讨去势大鼠股骨近段植入牛骨形成蛋白(bone morphorgeneic protein,BMP)后其骨生物力学强度及髓腔面积的变化。方法随机选取6月龄wistar雌性大鼠22只,摘除卵巢制作绝经后骨质疏松模型成功后,同一只动物双侧肢体对照,试验侧股骨颈植入牛骨形成蛋白及纤维蛋白(FS)复合物,对照侧植入纤维蛋白,术后4周、8周处死取材,测量股骨近端生物力学强度及髓腔面积和截面面积。结果4周后,试验侧与对照侧股骨近端骨生物力学强度和髓腔面积无明显差异;8周后,试验侧股骨近端生物力学强度较对照侧增高;髓腔面积较对照侧有较明显的减小(P<0.05)。结论股骨近端局部植入BMP可提高去势大鼠股骨近端局部的生物力学强度和减小近端髓腔面积和截面积,其可能减少骨质疏松性髋部骨折置换后假体的松动,成为骨质疏松性骨折假体置换中新的辅助治疗方法。     

TNF-α在沙漠干热环境下猪腹部肠管火器伤后肝组织中的表达

目的探讨沙漠干热环境下猪腹部肠管火器伤后肝脏组织TNF-α的表达和肝功能的变化。方法沙漠干热环境组和常温环境组健康长白仔猪各42头随机等分为对照组和伤后1、2、4、8、12 h和24 h组,实验组建立腹部火器伤肠管穿透模型后,用免疫组化及图像分析法测定各组肝脏组织内TNF-α的表达,同时测定血清中AST水平。结果伤后各组肝组织TNF-α表达明显高于对照组,沙漠干热环境组于伤后2 h和8 h出现2个高峰;常温环境组于伤后2 h和12 h出现2个高峰。血清AST水平于伤后显著增高,并于伤后2 h出现第1个高峰,沙漠干热环境组和常温环境组分别于伤后8 h和12 h出现第2个高峰。结论沙漠干热环境下腹部肠管火器伤后肝脏TNF-α的表达增加并与AST的变化趋势一致,而且峰值较常温组提前出现,提示TNF-α在腹部肠管火器伤后肝损伤过程中可能起重要作用。     

我国中医药胃肠动力基础实验方法研究进展

中药在胃肠动力动物基础实验研究,目前主要采用胃排空小肠推进率测定法、胃肠道腔外电桥式应力传感器记录法、胃肠激素测定(胃泌素、胃动素、生长抑素等)、免疫组织化学方法、离体体胃肠平滑肌肌条动力测定、胃肠内压描记法.采用最佳的实验研究方法,对中药的研究和认知具有重要的临床意义.     

主动加压减压心肺复苏对心跳骤停患者有效性的Meta分析

目的 系统性评价主动加压减压心肺复苏(ACD-CPR)对心跳骤停患者的有效性. 方法 利用Pubmed、Web of Science、COCHRANE LIBRARY、WanFang Data和CNKI Data等数据库检索建库至2020年1月的相关文献;严格按照纳入标准筛选文献、提取资料,应用Review Manag...     

益母草水提物对异丙肾上腺素致大鼠心肌重构的影响

目的:从心肌组织胶原表达的角度观察益母草水提物对实验性大鼠心肌重构的影响。方法:SD大鼠皮下注射异丙肾上腺素建立心肌重构模型,随机分为正常对照组、模型组、依那普利组及益母草水提物低、高剂量组,药物干预15 w。检测大鼠心脏血流动力学指标、心输出量、心脏质量系数、左室质量系数、心肌羟脯氨酸含量、心肌组织Ⅰ、Ⅲ型胶原含量。结果:与模型组比较,益母草水提物高剂量能改善模型大鼠LVSP、+dp/dtmax和CO(P<0.05),益母草低剂量能改善-dp/dtmax、心脏质量系数和左室质量系数、心肌组织羟脯氨酸含量及Ⅰ、Ⅲ型胶原含量、Ⅰ/Ⅲ型胶原比(P<0.05)。结论:高剂量益母草水提物能改善ISO致大鼠心肌重构模型心脏收缩功能;低剂量益母草水提物能改善ISO致大鼠心肌重构模型舒张功能,下调胶原表达,改善心肌胶原构成比,减轻心肌重构程度。     

李彦民主任医师治疗痹证应用乌头经验

痹证多见寒湿证型,临床治疗多用乌头。李彦民主任医师应用乌头强调辨证准确,多用复方监制其毒性,主张建立乌头用量和煎煮时间的比例,对乌头的煎煮用法和服用注意事项提出了独到的见解,临床应用也取得了满意的疗效。     

Flavonoids in myocardial ischemia–reperfusion injury: Therapeutic effects and mechanisms

Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.