胸部高分辨率CT对老年特发性肺纤维化的诊断价值

胸部高分辨率ＣＴ（ｈｉｇｈｒｅｓｏｌｕｔｉｏｎＣＴ，ＨＲＣＴ）的临床应用，显著地提高了特发性肺纤维化（ＩＰＦ）的诊断率。ＩＰＦ的ＨＲＣＴ检查典型表现是两肺弥漫性网织状影，蜂窝状影，散在肺大泡。常有胸膜肥厚，胸膜下线，肺的外周部呈现多发的直径１．５－３．０ｍｍ斑点状高密度影。本组１６例经ＨＲＣＴ扫描结合临床症状、体征、肺功能等项检查得以及时确诊及治疗，我们认为ＨＲＣＴ技术是目前诊断ＩＰＦ无创伤性检查中最精确的方法之一。     

Patent foramen ovale

Patent foramen ovale is incriminated in patients with cryptogenic stroke; however, concrete evidence that closure of patent foramen ovale using various devices is superior to continued medical therapy is not yet available. Controlled randomized trials are well underway to address this issue.     

In Vitro Activity and Beta-Lactamase Stability of BL-S786 Compared with Those of Other Cephalosporins

In vitro activity of BL-S786, a new parenterally semisynthetic cephalosporin, was investigated against 570 bacterial isolates. BL-S786 inhibited most Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella. It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin. It was not active against Serratia marcescens, Pseudomonas aeruginosa, or Bacteroides fragilis. BL-S786 was the least active new cephalosporin tested against staphylococci and was less active than cephalothin against streptococcal species. The activity of BL-S786 was not altered by the type of assay medium nor by 50% serum. The size of the test inoculum altered the minimal inhibitory and bactericidal concentrations for inhibition of some organisms, particularly those with Richmond type I β-lactamases. BL-S786 was not hydrolyzed by the R-factor-mediated, Richmond type III β-lactamase, but it was hydrolyzed by type I β-lactamases.     

中风病急性期综合治疗方案研究与评价--附522例临床研究报告

目的研究中风病急性期综合治疗方案的临床疗效。方法在前期研究基础上,开展了通治、辨治、针灸方案与西医治疗方案的多中心、随机对照研究,建立以辨证论治为特点的综合治疗方案,并进行验证和评价,共观察522例中风病急性期患者。结果缺血性中风综合治疗方案临床疗效优于西医组;通治方案、辨治方案和针灸方案在不同时间点对患者的神经功能、日常生活能力和认知功能都有不同程度的改善作用。结论以辨证论治为核心的综合治疗方案有其自身的优势与特点,对中风病具有积极的综合治疗作用,贴近临床实际,便于推广应用,各种评价量表在中风病不同时点具有不同的评价作用。     

大豆分离蛋白对果蝇寿命的影响

背景大豆蛋白具有降血脂、抑制肿瘤以及雌激素样作用等各种保健功效,但有关大豆分离蛋白对机体寿命影响的研究少见报道.目的观察大豆分离蛋白对果蝇寿命的影响,以探讨其抗衰老与抗氧化作用机制.设计以果蝇为研究对象的对照实验研究.单位一所大学公共卫生学院营养与食品卫生教研室.材料实验于2002-03/06在新疆医科大学公共卫生学院营养与食品卫生教研室果蝇室完成.美国野生型黑腹果蝇400只,雌、雄各半,由新疆医科大学公共卫生学院营养与食品卫生教研室提供.方法将400只果蝇分为1个对照组(普通培养基)和3个剂量组(分别为基础培养基含0.2%,1.0%,5.0%大豆分离蛋白).从实验第2天起,每天观察记录果蝇生存数和死亡数,直到全部果蝇死亡为止.计算果蝇平均寿命、半数死亡期和最高寿命. 主要观察指标果蝇平均寿命、半数死亡期和最高寿命.结果与对照组相比,大豆分离蛋白明显延长了雌雄果蝇寿命,并呈剂量反应关系,以高剂量组作用明显,其中雌雄果蝇平均寿命分别延长24.5%和20.7%;半数死亡时间分别延长27.1%和22.0%;最高寿命分别延长13.9%和10.6%.结论大豆分离蛋白能延长果蝇寿命,可能具有一定的延缓衰老作用.     

Transformation of the coordination nanostructures of 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid molecules on HOPG triggered by the change in the concentration of metal ions

The modulation effects of Cu²⁺/Fe³⁺ ions on the hydrogen-bonded structure of 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid (TATB) on a HOPG surface have been investigated at the liquid–solid interface by scanning tunneling microscopy (STM). STM observations directly demonstrated that the self-assembled honeycomb network of TATB has been dramatically transformed after introducing CuCl₂/FeCl₃ with different concentrations. The metal–organic coordination structures are formed due to the incorporation of the Cu²⁺/Fe³⁺ ions. Interestingly, a Cu²⁺ ion remains coordinated to two COOH groups and only the number of COOH groups involved in coordination doubles when the concentration of Cu²⁺ ions doubled. A Fe³⁺ ion changes from coordination to three COOH groups to two COOH groups after increasing the concentration of Fe³⁺ ions in a mixed solution. Such results suggest that the self-assembled structures of TATB molecules formed by metal–ligand coordination bonds can be effectively adjusted by regulating the concentration of metal ions in a mixed solution, which has rarely been reported before. It explains that the regulatory effect of concentration leads to the diversity of molecular architectures dominated by coordination bonds.

A Cu²⁺ ion maintains coordination with two COOH groups, while a Fe³⁺ ion changes from coordination with three to two COOH groups after increasing the concentration of Cu²⁺/Fe³⁺ ions.     

Enhanced photocatalytic hydrogen evolution and ammonia sensitivity of double-heterojunction g-C3N4/TiO2/CuO

The performance of semiconductor photocatalysts has been limited by rapid electron–hole recombination. One strategy to overcome this problem is to construct a heterojunction structure to improve the survival rate of electrons. In this context, a novel g-C₃N₄/TiO₂/CuO double-heterojunction photocatalyst was developed and characterized. Its photocatalytic activity for hydrogen production from water–methanol photocatalytic reforming was explored. Methanol is always used to eliminate semiconductor holes. The g-C₃N₄/TiO₂/CuO double-heterojunction photocatalyst with a narrow bandgap of ∼1.38 eV presented excellent photocatalytic activity for hydrogen evolution (97.48 μmol (g h)⁻¹) under visible light irradiation. Compared with g-C₃N₄/TiO₂ and CuO/TiO₂, the photocatalytic activity of g-C₃N₄/TiO₂/CuO for hydrogen production was increased approximately 7.6 times and 1.8 times, respectively. Below 240 °C, the sensitivity of g-C₃N₄/TiO₂/CuO to ammonia was approximately 90% and 46% higher than that of g-C₃N₄/TiO₂ and CuO/TiO₂, respectively. The enhancement of the photocatalytic activity and gas sensing properties of the g-C₃N₄/TiO₂/CuO composite resulted from the close interface contact established by the double heterostructure. The trajectory of electrons in the double heterojunction conformed to the S-scheme. UV-vis, PL, and transient photocurrent characterization showed that the double heterostructure effectively inhibited the recombination of e⁻/h⁺ pairs and enhanced the migration of photogenerated electrons.

The trajectory of electrons in the g-C3N4/TiO2/CuO double-heterojunction conforms to the S-scheme.     

Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation

DNA methyltransferase 3a (DNMT3a) is an important part of the epigenetic machinery that stabilizes patterns of activated T cell responses. We hypothesized that donor T cell DNMT3a regulates alloreactivity after allogeneic blood and marrow transplantation (allo-BMT). T cell conditional Dnmt3a KO mice were used as donors in allo-BMT models. Mice receiving allo-BMT from KO donors developed severe acute graft-versus-host disease (aGVHD), with increases in inflammatory cytokine levels and organ histopathology scores. KO T cells migrated and proliferated in secondary lymphoid organs earlier and demonstrated an advantage in trafficking to the small intestine. Donor T cell subsets were purified after BMT for whole-genome bisulfite sequencing (WGBS) and RNA-Seq. KO T cells had global methylation similar to that of WT cells, with distinct, localized areas of hypomethylation. Using a highly sensitive computational method, we produced a comprehensive profile of the altered epigenome landscape. Hypomethylation corresponded with changes in gene expression in several pathways of T cell signaling and differentiation. Additionally, Dnmt3a-KO T cells resulted in superior graft-versus-tumor activity. Our findings demonstrate a critical role for DNMT3a in regulating T cell alloreactivity and reveal pathways that control T cell tolerance. These results also provide a platform for deciphering clinical data that associate donor DNMT3a mutations with increased GVHD, decreased relapse, and improved survival.     

CLINICAL OBSERVATION ON TREATMENT OF CEREBRAL APOPLEXY-INDUCED APHASIA BY ACUPUNCTURE

Aphasiareferstothedisorderofvocalor-gandueto,degenerationoftheneuronsinthespeechcentercausedbythelesionofthespeechrepresentingareainthedorninanthemisphere.Itisnotassociatedwithdysacousisorparalysisoftheverbalmusclesinclinic.Basedontheirchar-acter,aphasiamaybeclassifiedintotwotypes:motorandsensoryaphasia.Inthepastfewyearswetreatedsuchdiseasebyemployingacupunc-ture,andtheresultwasanalysedincomparisionwiththatofthecontrolgroup.Thefollowingisoursummary.CLINICALDATAFortyeightpatientswereselec…     

Treatment of Alopecia Areata with Plum-blossom Needles plus Moxibustion： A Report of 53 Cases

用梅花针叩刺斑秃区,后用艾条在患处温灸,治疗斑秃患者53例,并以口服薄芝片为对照治疗54例.3个疗程后前者总有效率为96.2%,后者为70.4%,两组疗效差异有统计意义.