全文获取类型
收费全文 | 380篇 |
免费 | 41篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 13篇 |
妇产科学 | 14篇 |
基础医学 | 35篇 |
口腔科学 | 27篇 |
临床医学 | 43篇 |
内科学 | 52篇 |
皮肤病学 | 5篇 |
神经病学 | 49篇 |
特种医学 | 16篇 |
外科学 | 49篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 24篇 |
眼科学 | 8篇 |
药学 | 40篇 |
中国医学 | 3篇 |
肿瘤学 | 30篇 |
出版年
2024年 | 1篇 |
2023年 | 5篇 |
2022年 | 10篇 |
2021年 | 27篇 |
2020年 | 8篇 |
2019年 | 19篇 |
2018年 | 31篇 |
2017年 | 24篇 |
2016年 | 19篇 |
2015年 | 7篇 |
2014年 | 22篇 |
2013年 | 31篇 |
2012年 | 33篇 |
2011年 | 34篇 |
2010年 | 21篇 |
2009年 | 22篇 |
2008年 | 27篇 |
2007年 | 22篇 |
2006年 | 16篇 |
2005年 | 12篇 |
2004年 | 6篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1980年 | 2篇 |
1973年 | 1篇 |
排序方式: 共有422条查询结果,搜索用时 15 毫秒
11.
Bijan S. Kheirabadi Jennifer Sieber John B. Holcomb 《Journal of investigative surgery》2013,26(6):387-396
This study's objective was to investigate the potential thrombogenic effects of thrombin-containing fibrin sealant dressings (FSD) in a vascular repair model. Oval-shaped pieces of the rabbit abdominal aorta and vena cava were excised, the injuries were repaired with FSD, and animals were allowed to recover. Thrombus formation was examined by (1) an infusion of indium-labeled platelets into the rabbits following FSD application and estimation of total number of platelets attached to the wounds at 2, 4, and 6 h later (short-term effect, n = 12); and by (2) morphological and histological examinations of the vessels and dressings on days 1, 3, and 7 after repair operation in another group of rabbits (long-term effect, n = 12). Application of FSD sealed the vascular injures and produced immediate hemostasis that was stable up to 1 week. The highest numbers of platelets (both native and labeled) adhered to the arterial and venous repair sites were 6.5 × 106 and 4.4 × 107, respectively, 6 h after operation. The adhered platelets, however, did not form a visible and clinically significant thrombus. In long-term experiments, no evidence of thrombus was found in the lumens of the repaired vessels or on the dressings, and no microthrombi were detected histologically in other tissues at any time point. Although vena caval injuries showed signs of healing at day 7 postoperatively, the aortic wounds expanded progressively (pseudoaneurysm) and were prone to rupture at later times. Thus, direct exposure of FSD does not cause intravascular thrombosis or thrombotic events in rabbits. The dressing appears to be safe and effective for short-term repair of vascular injuries. It may also allow healing of minor venous defects, but cannot replace conventional surgical techniques (suturing) for permanent repair of arterial damages. 相似文献
12.
Utility of early influenza diagnosis through point‐of‐care testing in children presenting to an emergency department
下载免费PDF全文
![点击此处可从《Journal of paediatrics and child health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
13.
14.
Synthesis,evaluation, and molecular docking studies of aryl urea‐triazole‐based derivatives as anti‐urease agents
下载免费PDF全文
![点击此处可从《Archiv der Pharmazie》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Setareh Moghimi Fereshteh Goli‐Garmroodi Maryam Allahyari‐Devin Hedieh Pilali Malihe Hassanzadeh Shabnam Mahernia Mohammad Mahdavi Loghman Firoozpour Massoud Amanlou Alireza Foroumadi 《Archiv der Pharmazie》2018,351(7)
15.
Elnaz Mohammad Alizadeh Majid Mahdavi Forough Jenani Fard Solmaz Chamani Fereshteh Farajdokht 《Toxicology mechanisms and methods》2018,28(8):622-629
Oxidative stress has a causative role in ischemic reperfusion-induced cell death. Evidence has shown that metformin is capable to reduce ischemic reperfusion injuries. The current study investigated the effect of metformin on ischemia/reperfusion-induced apoptosis in PC12 cells by evaluation of Bcl-2 family proteins expression. Cells were exposed to a time-dependent in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) injury and then treated with metformin. The intracellular reactive oxygen species (ROS) levels were measured. Western blotting was used to examine the expression of anti- and pro-apoptotic proteins. Moreover, the number of apoptotic cell death was evaluated by TUNEL assay. Our results showed that metformin attenuated ROS generation, downregulated pro-apoptotic BAX expression, and upregulated expression of the Bcl-2 protein in the PC12 cells. Moreover, metformin reduced cell death under OGD/R condition which was confirmed by lower apoptotic cell death in the TUNEL assay. These findings suggest that neuroprotective effect of metformin on OGD/R-induced cell death is possibly mediated by inhibition of ROS-induced apoptosis pathway. 相似文献
16.
17.
18.
19.
Liping Zhang Emily C. Cherney Xiao Zhu Tai-an Lin Johnni Gullo-Brown Derrick Maley Kathy Johnston-Allegretto Lisa Kopcho Mark Fereshteh Christine Huang Xin Li Sarah C. Traeger Gopal Dhar Aravind Anandam Sandeep Mahankali Shweta Padmanabhan Prabhakar Rajanna Venkata Murali Thanga Mariappan Robert Borzilleri Gregory Vite John T. Hunt Aaron Balog 《ACS medicinal chemistry letters》2021,12(3):494
Indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as a target for small-molecule immunotherapy for the treatment of a variety of cancers including renal cell carcinoma and metastatic melanoma. This work focuses on the identification of IDO1 inhibitors containing replacements or isosteres for the amide found in BMS-986205, an amide-containing, IDO1-selective inhibitor currently in phase III clinical trials. Detailed subsequently are efforts to identify a structurally differentiated IDO1 inhibitor via the pursuit of a variety of heterocyclic isosteres, leading to the discovery of highly potent, imidazopyridine-containing IDO1 inhibitors. 相似文献
20.