全文获取类型
收费全文 | 1075篇 |
免费 | 57篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 13篇 |
妇产科学 | 14篇 |
基础医学 | 63篇 |
口腔科学 | 15篇 |
临床医学 | 125篇 |
内科学 | 306篇 |
皮肤病学 | 35篇 |
神经病学 | 84篇 |
特种医学 | 17篇 |
外科学 | 208篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 83篇 |
眼科学 | 22篇 |
药学 | 71篇 |
中国医学 | 14篇 |
肿瘤学 | 43篇 |
出版年
2023年 | 20篇 |
2022年 | 45篇 |
2021年 | 66篇 |
2020年 | 29篇 |
2019年 | 33篇 |
2018年 | 44篇 |
2017年 | 25篇 |
2016年 | 40篇 |
2015年 | 32篇 |
2014年 | 41篇 |
2013年 | 71篇 |
2012年 | 90篇 |
2011年 | 90篇 |
2010年 | 41篇 |
2009年 | 37篇 |
2008年 | 81篇 |
2007年 | 67篇 |
2006年 | 37篇 |
2005年 | 45篇 |
2004年 | 31篇 |
2003年 | 24篇 |
2002年 | 22篇 |
2001年 | 5篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 6篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1974年 | 1篇 |
1969年 | 2篇 |
1967年 | 3篇 |
1966年 | 10篇 |
1965年 | 3篇 |
1963年 | 1篇 |
1946年 | 1篇 |
1945年 | 1篇 |
排序方式: 共有1134条查询结果,搜索用时 0 毫秒
61.
62.
Winkler MH Khan FA Kulinskaya E Hoh IM McDonald D Boustead G Kaisary AV 《BJU international》2004,94(6):812-815
OBJECTIVE: To examine whether the simple variable 'percentage of cancer-positive biopsy cores' is a significant predictor of true pathological stage after radical prostatectomy and can be used to improve pathological stage prediction by simple means. PATIENTS AND METHODS: In all, 375 patients had a radical prostatectomy for localized prostate cancer in two UK centres; 260 had complete preoperative staging information. Logistic regression was used and predicted probability graphs constructed to assess predictors of pathological stage. RESULTS: In this study, only PSA (P = 0.004) and percentage cancer-positive biopsy cores (P < 0.001) were significant predictors of pathological stage. The final model was an acceptable classifier for pathological stage (area under the receiver operating characteristic curve 0.76, specificity 85%, sensitivity 47%). A patient with a PSA of 10 ng/mL and one of six cores positive for cancer would have a predicted probability of extraprostatic disease of 20%, whereas the same patient with all six biopsy cores positive would have a predicted probability of extraprostatic disease of 80%. CONCLUSIONS: The percentage of cancer-positive biopsy cores significantly predicts the disease stage after radical prostatectomy. This variable is easy to obtain by the clinician and avoids the need to estimate the percentage of biopsy tissue infiltrated by cancer. This readily available information can easily be computed and may help to counsel patients about realistic expectations of organ-confined disease in relation to surgery as a treatment option. 相似文献
63.
Abbasi MA Ahmad VU Zubair M Fatima N Farooq U Hussain S Lodhi MA Choudhary MI 《Planta medica》2004,70(12):1189-1194
A re-investigation of the chemical constituents of the stem bark of Symplocos racemosa Roxb. led to the isolation of four new glycosides, symplocomoside (1), symponoside (2), symplososide (3) and symploveroside (4). Benzoylsalireposide (5) and salireposide (6) were re-isolated from this plant. The structures of the new compounds were determined by 1D and 2D-homonuclear and heteronuclear NMR spectroscopy, chemical evidence, and by comparison with the published data of the closely related compounds. The glycosides 1-4 displayed in vitro inhibitory activity against phosphodiesterase I with IC50 values of 122 +/- 0.017, 698 +/- 0.06, 722 +/- 0.03, 909 +/- 0.09 microM, respectively. The compounds 1-6 also showed in vitro inhibitory activity against thymidine phosphorylase with IC50 values of 189.96 +/- 1.02, 195.56 +/- 2.36, 207.61 +/- 1.06, 488.89 +/- 4.10, 427.20 +/- 5.36, 354.2 +/- 5.69 microM, respectively while 1 was also found to be a urease inhibitor with an IC50 value of 54.13 +/- 0.71 microM. 相似文献
64.
Cooper D Pride MW Guo M Cutler M Mester JC Nasar F She J Souza V York L Mishkin E Eldridge J Natuk RJ 《Vaccine》2004,23(2):236-246
The type of immune response elicited against HSV-2 infection may be a factor in the frequency and severity of recurrent disease, with non-recurrent status being associated with a Th1-like response. As administration of glycoprotein D subunit formulated with an aluminum-based adjuvant induces predominantly Th2-like immune responses, we sought to assess the ability of IL-12 to redirect anti-HSV immunity towards a Th1 response. Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity. Spleen cells from mice immunized with gD and IL-12, and restimulated in vitro with HSV-2, developed into effector cells capable of secreting IFN-gamma and lysing HSV-2 infected targets, while those obtained from gD or gD/ALPO4 immunized mice did not express lytic activity. In vitro studies determined that these CTLs were CD4+ and that the cytotoxicity was primarily perforin dependent. Vaginal challenge with HSV-2 demonstrated that IL-12 co-administration with gD resulted in increased efficacy of this vaccine as compared to administration of gD antigen alone. This acquired protection persisted up to 1 year. Finally, adsorbing gD and IL-12 to AlPO4 decreased the optimal dose of IL-12 required to enhance gD immunogenicity and shift responses towards a Th1-like profile. 相似文献
65.
66.
Rahman J Rahman FZ Rahman W al-Suleiman SA Rahman MS 《The Journal of reproductive medicine》2003,48(9):723-728
OBJECTIVE: To analyze the maternal and fetal outcomes of pregnancy and gynecologic problems in women with Marfan syndrome. STUDY DESIGN: The outcomes of 14 pregnancies in 4 women with Marfan syndrome were prospectively observed between January 1988 and December 2000. The cardiovascular and obstetric complications were analyzed. During pregnancy all the patients were carefully monitored with serial echocardiography and close attention to symptoms. RESULTS: Of the 14 pregnancies, 5 (35.7%) ended in abortion, and 3 of them occurred in the early second trimester due to cervical incompetence. Premature onset of labor occurred in 2 pregnancies at 31 and 34 weeks. Postpartum hemorrhage complicated 3 deliveries, and inversion of the uterus occurred in 1 patient. Significant cardiovascular complications occurred in 2 patients, who required surgical correction of the aortic aneurysm and replacement of the aortic valve. In one patient the operation was performed within hours of vaginal delivery, and the other patient underwent surgery 8 weeks postpartum. No maternal death occurred in the study. One infant in the series was diagnosed as having Marfan syndrome. A premature infant delivered at 31 weeks died on the second day of life. CONCLUSION: Women with Marfan syndrome are at high risk of aortic dissection in pregnancy even in the absence of preconceptional aortic root dilatation. Obstetric complications in patients with this condition have been underreported in the past. Women with aortic root dilatation of < 40 mm usually tolerate pregnancy well, with good maternal and fetal outcomes. Women with Marfan syndrome should be counseled regarding the risk of pregnancy to both mother and fetus. Patients who have cardiac decompensation or aortic dilatation > 40 mm are advised to avoid pregnancy. 相似文献
67.
68.
69.
Success rates of formocresol pulpotomy and indirect pulp therapy in the treatment of deep dentinal caries in primary teeth 总被引:3,自引:0,他引:3
PURPOSE: This study was performed to retrospectively evaluate treatment of deep caries in primary molars with formocresol pulpotomy (FP) and indirect pulp therapy (IPT). METHODS: 133 primary molars with deep caries approaching the pulp were treated with FP (N = 78) or IPT (N = 55) and followed 2-7 years. All IPTs received immediate stainless steel crowns (SSCs); 61 FPs got an immediate SSC, 13 an intermediate restorative material (IRM), and 4 amalgam. Thirteen IPTs and 25 FPs had pre-operative pain compatible with a diagnosis of reversible pulpitis. Treatment notes and radiographs were independently assessed. RESULTS: Overall IPT success was 93% (51/55) versus 74% (58/78) for FP. Molars with pain compatible with a diagnosis of reversible pulpitis were successfully treated by IPT 85% (11/13) versus 76% (19/25) for FP. FP-treated molars exhibited earlier exfoliation 38% (30/78), while all IPT molars exhibited normal exfoliation. FPs receiving immediate SSCs had 50/61 (82%) succeed; FPs restored with an IRM temporary succeeded 5/13 (39%), amalgam 3/4 (75%). CONCLUSIONS: IPT success was significantly higher than FP (P = 0.01) in the treatment of deep caries. Both IPT and FP were successful in treating teeth with pain compatible with the diagnosis of reversible pulpitis. FP significantly hastened the exfoliation of pulpotomized primary molars (P = 0.001). IPT in primary teeth can be successfully used in a one step procedure. SSCs placed immediately after FP significantly increased FP success vs. FP followed by IRM temporary (P = 0.01). 相似文献
70.
Agricultural produce in the dry bed of the River Ganga in Kanpur, India--a new source of pesticide contamination in human diets. 总被引:3,自引:0,他引:3
R K Hansi M Farooq G S Babu S P Srivastava P C Joshi P N Viswanathan 《Food and chemical toxicology》1999,37(8):847-852
Vegetables grown in the dry bed field of the River Ganga in Kanpur, an important industrial city of North India, were analysed for the pesticides hexachlorocyclohexane (HCH), dichlorodiphenyl trichloroethane (DDT), their isomers and metabolites at three different sites. Residues of both the pesticides were found in all the samples. Mean levels of 109.35, 136.76 and 145.93 microg HCH/kg and 6.64, 49.3 and 46.70 microg DDT/kg were found in the rural upstream, city and downstream industrial areas, respectively. The mean total HCH and DDT levels were within safe limits as per the Indian Standard but some samples had HCH levels above the WHO/FAO limit. The pesticide residue level in vegetables was several fold higher than their surrounding sandy soil and could pose health problems since these popular vegetables are consumed regularly by the population. 相似文献