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Eugen Krech Silvia Selinski Meinolf Blaszkewicz Hannah Bürger Thura Kadhum Jan G. Hengstler 《Journal of toxicology and environmental health. Part A》2017,80(7-8):430-438
ABSTRACTThis study was performed to investigate the frequency of bladder cancer in patients with an occupational history such as underground hard coal mining and/or painting after the structural change in the local industry. A total of 206 patients with bladder cancer and 207 controls were enlisted regarding occupational and nonoccupational bladder cancer risk factors by questionnaire. The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP) rs11892031[A/C] reported to be associated with bladder cancer in genome-wide association studies were genotyped. The bladder cancer risk in varnishers and underground hard coal miners was increased as previously shown in a study in this area performed in the 1980s. The occupation of a car mechanic was associated with a significantly elevated bladder cancer risk and higher in the case of underground hard coal miners even though the mine was closed in 1987. The frequency of GSTM1 negative genotype was comparable in cases and controls (53% versus 54%). In the case of NAT2, the slow NAT2 genotype was more frequent (62% versus 58%) and ultra-slow NAT2 genotype (NAT2*6A and/or *7B alleles only) was 23% versus 15%. An occupational history of a varnisher or an underground hard coal miner remains a risk factor for bladder cancer occurrence. Data indicate that in the case of bladder cancer, GSTM1 is a susceptibility factor related to environmental and/or occupational exposure. 相似文献
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Bendamustine and rituximab in combination with lenalidomide in patients with chronic lymphocytic leukemia 下载免费PDF全文
Jasmin Bahlo Sandra Kluth Christina Rhein Paula Cramer Carolin Gross‐Ophoff Petra Langerbeins Anna‐Maria Fink Barbara Eichhorst Karl‐Anton Kreuzer Norbert Fischer Eugen Tausch Stephan Stilgenbauer Sebastian Böttcher Hartmut Döhner Michael Kneba Martin Dreyling Mascha Binder Michael Hallek Clemens‐Martin Wendtner the German CLL Study Group 《European journal of haematology》2016,97(3):253-260
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Intestinal pseudo-obstruction (IPO) either acute or chronic is a condition including features of intestinal ileus in absence of mechanical obstruction. Our paper presents such a rare case of idiopathic IPO in a 53-year-old male patient with recurrent episodes of pseudo-obstruction, which were successfully resolved by anticholinesterase agents, motilin agonists or colonic decompression. However, the patient finally underwent total colectomy. Huge colonic dilatation was identified intraoperatorily, while histology showed a neuropathic variant of chronic intestinal pseudo-obstruction. Etiologic mechanisms and current therapeutic methods are reviewed in this paper, which concludes that IPO is a condition in which conservative treatment usually fails. Total colectomy with ileoanal pouch may be the only solution in these situations. 相似文献
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Embolic protection devices for carotid artery stenting: better results than stenting without protection? 总被引:11,自引:0,他引:11
Ralf Zahn Bernd Mark Nikolaj Niedermaier Uwe Zeymer Peter Limbourg Thomas Ischinger Klaus Haerten Karl Eugen Hauptmann Enz-Rüdiger von Leitner Wolfgang Kasper Ulrich Tebbe Jochen Senges 《European heart journal》2004,25(17):1550-1558
AIMS: Carotid artery stenting (CAS) for carotid artery stenoses has become an alternative to carotid endarterectomy. However, CAS itself can cause cerebral ischaemic events. Embolic protection devices (PD) promise to reduce the incidence of these events. METHODS AND RESULTS: From July 1996 to March 2003, 1483 patients from 26 hospitals were included in the prospective CAS Registry of the ALKK study group. A PD was used in 668 of 1483 patients (45%). The use of a PD has grown rapidly over the years and reached 100% in 2003. Patients treated with a PD had prior carotid artery dilatation more often (3.5% versus 1%, p < 0.001), a prior myocardial infarction (34% versus 27.4%, p = 0.007) and a history of arterial hypertension (89.9% versus 78.6%, p = 0.007) compared to patients treated without a PD. A thrombus was more often visible in patients treated under distal protection (16.5% versus 8%, p < 0.001). The use of a PD led to a 10-min longer intervention (45 min versus 35 min median, p < 0.001). Patients treated with a PD had a lower rate of ipsilateral stroke (1.7% versus 4.1%, p = 0.007) and a lower rate of all non-fatal strokes and all deaths (2.1% versus 4.9%, p = 0.004) during the hospital stay. This was confirmed by multiple logistic regression analysis (adjusted OR = 0.45, 95% CI: 0.23-0.91, p = 0.026). A similar reduction could be found for symptomatic as well as asymptomatic carotid artery stenoses. CONCLUSION: Since 1996 there has been a steady increase in the use of PDs for CAS, with a 100% use in 2003. The use of a PD may lower the rate of ipsilateral strokes during CAS. 相似文献
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Karl Egerer Julia Hertzer Eugen Feist Anja Albrecht Paul Eberhard Rudolph Thomas Drner Gerd‐Rüdiger Burmester 《Arthritis care & research》2003,49(4):546-548