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61.
J. Pfisterer F. Kommoss W. Sauerbrei B. Baranski M. Kiechle H. Ikenberg A. Du Bois & A. Pfleiderer 《International journal of gynecological cancer》1996,6(1):54-60
In a retrospective study the prognostic significance of nuclear DNA content was investigated, as measured by flow cytometry, of the tumor specimens from 212 women with nonpretreated FIGO stage IB and II cervical cancer. One-hundred and thirty cases (62%) were found to be diploid, whereas 82 (38%) were aneuploid. Univariate analysis of the follow-up data showed an increased relative risk (RR) for recurrence free survival (RFS) for stage II tumors (RR = 1.87, 95% CI: 1.13–3.10, P = 0.015) and for age (RR = 1.52, 95% CI: 0.66–3.52 and RR = 2.35, 95% CI: 1.19–4.65, P = 0.032). Ploidy showed a relative risk of 1.33 (95% CI: 0.83–2.13, NS). In addition, univariate analysis of overall survival (OS) revealed similar results. For the subgroup of patients with primary surgery ( n = 151), positive pelvic nodes (RR = 5.38, 95% CI: 2.70–10.71, P = 0.0001) and parametrial extension (RR = 2.53, 95% CI: 1.24–5.17, P = 0.011) were significant factors for OS after univariate analysis, the estimated effects on RFS were slightly smaller. Multivariate analysis of RFS for the whole study population showed age, histologic grade and stage with a slightly increased risk, but no effect was significant. Ploidy with an RR of 0.97 (95% CI: 0.58–1.62) seems to have no influence on prognosis. For the subgroup with primary surgery, ploidy again failed statistical significance with an RR of 1.20 (95% CI: 0.58–2.49). Our results suggest that abnormalities of the nuclear DNA content in this homogeneous group of patients are associated with clinical and morphological prognosticators, however, ploidy is not an independent prognostic factor for RFS, or for the whole study population or for the subgroup with primary surgery. 相似文献
62.
Da-Nian Zhu, Long-Mei Xue, Peng Li. Effect of central muscarine receptor blockade. with DKJ-21 on the blood pressure and heart rote in stress-induced hypertensive rats.
The experiments were performed on Wistar or Sprague-Dawley rats of both sexes divided at random into stress and control groups. The rats in the stress groups were put into cages and subjected to electric foot-shocks and noises for 9-15 days, which caused an increase in blood pressure (BP) and heart rate (HR). In hypertensive rats DKJ-21 (4mg/lml) was injected intravenously (i.v.), and 0.5-1.0h after administration the BP and HR dropped from the high level to normotensive level. In normotensive rats, however, administration of DKJ-21 had no effect on BP or HR. In separate groups of normotensive rats, pretreatment of DKJ-21 (4 mg/l ml, i.v.) blocked the pressor and tachycardiac effect induced by microinjection of physostigmine (0.4μg/0.1 /μl/site), corticosterone (40μg/0.1μl/site) or aldosterone (40 μg/0.1 μl/site) into the rostral ventrolateral medulla (rVLM). Furthermore, DKJ-21 also attenuated the enhancement of the pressor response to stimulation of the defense area in the midbrain, which was induced by microinjection of drugs (mentioned above) into the rVLM. These results indicate that i.v. DKJ-21 can selectively block the muscarinic receptors in the rVLM in stress-induced hypertensive rats, which suggests that abnormal enhancement of cholinergic mechanism in the rVLM may be related to hypertensive effects of corticoids in this area. 相似文献
The experiments were performed on Wistar or Sprague-Dawley rats of both sexes divided at random into stress and control groups. The rats in the stress groups were put into cages and subjected to electric foot-shocks and noises for 9-15 days, which caused an increase in blood pressure (BP) and heart rate (HR). In hypertensive rats DKJ-21 (4mg/lml) was injected intravenously (i.v.), and 0.5-1.0h after administration the BP and HR dropped from the high level to normotensive level. In normotensive rats, however, administration of DKJ-21 had no effect on BP or HR. In separate groups of normotensive rats, pretreatment of DKJ-21 (4 mg/l ml, i.v.) blocked the pressor and tachycardiac effect induced by microinjection of physostigmine (0.4μg/0.1 /μl/site), corticosterone (40μg/0.1μl/site) or aldosterone (40 μg/0.1 μl/site) into the rostral ventrolateral medulla (rVLM). Furthermore, DKJ-21 also attenuated the enhancement of the pressor response to stimulation of the defense area in the midbrain, which was induced by microinjection of drugs (mentioned above) into the rVLM. These results indicate that i.v. DKJ-21 can selectively block the muscarinic receptors in the rVLM in stress-induced hypertensive rats, which suggests that abnormal enhancement of cholinergic mechanism in the rVLM may be related to hypertensive effects of corticoids in this area. 相似文献
63.
64.
Effect of isoelectric point on biodistribution and inflammation imaging with indium-111-labelled IgG
Caroline I. ten Kate Alan J. Fischman Robert H. Rubin A. J. Fucello D. Riexinger Robert A. Wilkinson Lina Du Ban An Khaw H. William Strauss 《European journal of nuclear medicine and molecular imaging》1990,17(6-8):305-309
Electrostatic effects play an important role in protein interactions and may alter the biodistribution of antibodies. To study the effect of molecular charge on the biodistribution and infection imaging properties of human polyclonal immunoglobulin G (IgG), its iso electric point was varied by changing the level of diethylene triamine penta-acetic acid (DTPA) substitution: 0.8, 0.9, 3.7, 5.1 and 5.9 DTPA/IgG. Biodistributions of the different IgG preparations were determined at 10 min, 1, 6, 24, and 48 h post injection in normal rats, and infection imaging properties were determined in rats withEscherichia coli thigh infections. The biodistribution was significantly affected by pl. The immunoglobulin preparations with 0.9 and 3.7 DTPA/IgG showed faster clearance from the circulation and generally lower accumulation in most organs. The images had a target-to-background ratio of approximately 1.3–2.3:1. These results suggest that even though targeting is not affected by the level of DTPA substitutions, preparations with 0.9 and 3.7 DTPA/IgG may be superior imaging agents because of reduced accumulation by background organs. 相似文献
65.
在微量注射大量肝脏mRNA之后,通过电压箝方法进行功能鉴定,两栖类卵母细胞成功地表达了AVPV1a受体。但在灌流AV4-8溶液时,却不能诱导卵母细胞产生内向振荡电流反应。提示AVP4-8不能通过AVPV1a受体而介导生理学效应。 相似文献
66.
30例肝硬化食管静脉曲张破裂大出血患者,用垂体后叶素0.2~0.4U/min连续静脉滴注和硝酸甘油含服联合治疗。结果表明,近期止血有效申达80%,死亡率10%;无一例出现严重心绞痛和心电图异常。 相似文献
67.
用PowerPoint XP设计幻灯片元素动画效果的实践 总被引:6,自引:1,他引:5
PowerPoint XP新特性中突出的就是其动画设计功能的加强。文中对新增加的与动画没计相关的功能使用要点结合实际作了较详细的叙述。 相似文献
68.
作者以ABEI-CoCl_2-H_2O_2作为化学发光指示系统,用固相竞争法检测58例白细胞减少症患者、41例无白细胞减少症患者及32例正常人等的粒细胞抗体IgG。判断标准采用正常人血清化学发光强度指数法。实验结果表明,白细胞减少症患者血清中粒细胞抗体阳性率明显高于无白细胞减少症患者(P<0.005)。本法敏感性为43.1%,特异性为90.2%,准确性为62.6%,是一种灵敏而准确的方法,能将粒细胞包被试管在室温下较长时间保存,以供临床监测粒细胞抗体,大大缩短检测时间。 相似文献
69.
10例椎管内转移癌病人曾长期使用大剂量镇痛药难以奏效,而少数病例便采用硬膜外腔注射吗啡2~4mg疼痛缓解仅1h。采用硬膜外腔灌注氨甲喋呤配伍高渗盐水,使抗癌药直接与肿瘤接触,几分钟内杀死癌细胞,加之高渗盐水能促使肿瘤和神经干脱水,肿瘤体积缩小和破坏,改善局部动脉缺血和组织水肿,从而减轻或消除肿瘤对神经根的压迫,缓解和消除神经痛。 相似文献
70.
护理人员的职业损伤因素及健康维护 总被引:27,自引:0,他引:27
作者指出临床一线的护理人员是发生职业损伤的高危群体。产生职业损伤的危险因素包括基础教育和继续教育缺乏职业损伤及其防范知识;影响护理人员身体健康的诸因素,如化疗专用的溶药设备、洁净操作台或相对密闭的溶药环境不健全;乙型肝炎等医院内易感性等疾病增加,被血液、体液等污染的医疗锐器刺伤是护理人员职业感染的主要途径;护理人员工作职业特点对健康不利的影响,护理人员心理压力大。为维护护理人员身心健康,应加入医院感染、职业损伤和健康维护的在校理论教育内容,加强护理人员职业安全教育,采取防范职业损伤的措施,如化疗药物中心配药、使用一次性手套等措施。 相似文献