全文获取类型
收费全文 | 402874篇 |
免费 | 28551篇 |
国内免费 | 2311篇 |
专业分类
耳鼻咽喉 | 4954篇 |
儿科学 | 9388篇 |
妇产科学 | 8244篇 |
基础医学 | 55694篇 |
口腔科学 | 7812篇 |
临床医学 | 39602篇 |
内科学 | 81840篇 |
皮肤病学 | 7622篇 |
神经病学 | 35672篇 |
特种医学 | 16165篇 |
外国民族医学 | 11篇 |
外科学 | 59143篇 |
综合类 | 5518篇 |
现状与发展 | 5篇 |
一般理论 | 395篇 |
预防医学 | 30265篇 |
眼科学 | 10584篇 |
药学 | 30124篇 |
4篇 | |
中国医学 | 1941篇 |
肿瘤学 | 28753篇 |
出版年
2023年 | 1919篇 |
2022年 | 2643篇 |
2021年 | 10052篇 |
2020年 | 5595篇 |
2019年 | 8696篇 |
2018年 | 10173篇 |
2017年 | 7562篇 |
2016年 | 8960篇 |
2015年 | 11268篇 |
2014年 | 15220篇 |
2013年 | 19846篇 |
2012年 | 30063篇 |
2011年 | 30596篇 |
2010年 | 17499篇 |
2009年 | 15237篇 |
2008年 | 25411篇 |
2007年 | 26110篇 |
2006年 | 25227篇 |
2005年 | 24798篇 |
2004年 | 22882篇 |
2003年 | 20857篇 |
2002年 | 19124篇 |
2001年 | 6437篇 |
2000年 | 5603篇 |
1999年 | 5548篇 |
1998年 | 4323篇 |
1997年 | 3497篇 |
1996年 | 3092篇 |
1995年 | 2925篇 |
1994年 | 2476篇 |
1993年 | 2185篇 |
1992年 | 2814篇 |
1991年 | 2709篇 |
1990年 | 2336篇 |
1989年 | 2196篇 |
1988年 | 2108篇 |
1987年 | 1970篇 |
1986年 | 1947篇 |
1985年 | 1834篇 |
1984年 | 1854篇 |
1983年 | 1673篇 |
1982年 | 1754篇 |
1981年 | 1653篇 |
1980年 | 1447篇 |
1979年 | 1200篇 |
1978年 | 1132篇 |
1977年 | 999篇 |
1976年 | 904篇 |
1975年 | 753篇 |
1974年 | 822篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
David M. Presby Michael C. Rudolph Vanessa D. Sherk Matthew R. Jackman Rebecca M. Foright Kenneth L. Jones Julie A. Houck Ginger C. Johnson Janine A. Higgins P. Darrell Neufer Robert H. Eckel Paul S. MacLean 《Diabetes》2021,70(4):867
Moderate weight loss improves numerous risk factors for cardiometabolic disease; however, long-term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that suppress energy expenditure and facilitate weight regain. Skeletal muscle has a prominent role in energy homeostasis; therefore, we investigated the effect of WLM and weight regain on skeletal muscle in rodents. In skeletal muscle of obesity-prone rats, WLM reduced fat oxidative capacity and downregulated genes involved in fat metabolism. Interestingly, even after weight was regained, genes involved in fat metabolism were also reduced. We then subjected mice with skeletal muscle lipoprotein lipase overexpression (mCK-hLPL), which augments fat metabolism, to WLM and weight regain and found that mCK-hLPL attenuates weight regain by potentiating energy expenditure. Irrespective of genotype, weight regain suppressed dietary fat oxidation and downregulated genes involved in fat metabolism in skeletal muscle. However, mCK-hLPL mice oxidized more fat throughout weight regain and had greater expression of genes involved in fat metabolism and lower expression of genes involved in carbohydrate metabolism during WLM and regain. In summary, these results suggest that skeletal muscle fat oxidation is reduced during WLM and regain, and therapies that improve skeletal muscle fat metabolism may attenuate rapid weight regain. 相似文献
75.
76.
PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
77.
78.
79.
Christopher Yeh Cem Atillasoy John T. Seykora Vivian Lee 《Journal of cutaneous pathology》2021,48(1):171-173
Respiratory cysts are benign lesions lined by normal respiratory epithelium. There are few reported cases localized to the orbit, while those of the eyelid are exceedingly rare. Respiratory cysts usually arise either from a non‐hereditary congenital malformation, where they are distinguished as choristomatous, or from trauma. Here, we report a case of a 53‐year‐old man who presented with a large right lower eyelid cyst that was histopathologically diagnosed as a respiratory cyst. 相似文献
80.
Yoo Min Han Su Jin Chung Seokha Yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo Sung Kim 《World journal of gastroenterology : WJG》2022,28(8):853-867
BACKGROUND Helicobacter pylori(H.pylori)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal atrophy.However,little is known about the relationship between atrophic gastritis(AG)and GERD.AIM To confirm the inverse correlation between AG and the occurrence and severity of GERD.METHODS Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were included.The grade of reflux esophagitis was evaluated according to the Los Angeles classification.Endoscopic AG(EAG)was categorized into six grades.Serologic AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤3.0.The association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression analysis.RESULTS In total,4684 individuals with GERD were compared with 21901 healthy controls.In multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of GERD.Seropositivity for H.pylori immunoglobulin G antibodies was associated with a decreased risk of GERD.There was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in O3.Additionally,the extent of EAG showed an inverse correlation with the severity of GERD.The presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of GERD.AG followed by H.pylori infection may be independently protect against GERD. 相似文献