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141.
Laíse dos Santos PEREIRA Erlane Chaves FREITAS Arduína Sofia Ortet de Barros Vasconcelos FIDALGO M?nica Coelho ANDRADE Darlan da Silva C?NDIDO José Dami?o da SILVA FILHO Vladimir MICHAILOWSKY Maria de Fátima OLIVEIRA José Ajax Nogueira QUEIROZ 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(2):145-152
By controlling the transmission of Chagas disease, the challenge of providing
assistance to millions of infected patients that reach old age arises. In this study,
the socioeconomic, demographic and comorbidity records of all elderly chagasic
patients followed at the Pharmaceutical Care Service of the Chagas Disease Research
Laboratory were assessed. The information related to the clinical form of the disease
was obtained from medical records provided by the Walter Cantídio University
Hospital. The profile of the studied population was: women (50.5%); mean age of 67
years; retired (54.6%); married (51.6 %); high illiteracy rate (40.2%); and family
income equal to the minimum wage (51.5%). The predominant clinical forms of Chagas
disease were cardiac (65.3%) and indeterminate (14.7%). The main electrocardiographic
changes were the right bundle branch block (41.0%), associated or not with the
anterosuperior left bundle branch block (27.4%). The average number of comorbidities
per patient was 2.23 ± 1.54, with systemic arterial hypertension being the main one
found (67.0%). It was found that the elderly comprise a vulnerable group of patients
that associate aging with cardiac and/or digestive disorders resulting from the
evolution of Chagas disease and other comorbidities, which requires special attention
from health services to ensure more appropriate medical and social care. 相似文献
142.
143.
Zamin C Silva-Sousa YT Souza-Gabriel AE Messias DF Sousa-Neto MD 《Dental traumatology》2012,28(4):282-286
Abstract – Aim: To assess the influence of cervical preparation on fracture susceptibility of roots. Material and methods: During root canal instrumentation, the cervical portions were prepared with different taper instruments: I: no cervical preparation; II: #30/.08; III: #30/.10; IV: #70/.12. The specimens were sealed with the following filling materials (n = 8), A: unfilled; B: Endofill/gutta‐percha; C: AH Plus/gutta‐percha; D: Epiphany SE/Resilon. For the fracture resistance test, a universal testing machine was used at 1 mm per minute. Results: anova demonstrated difference (P < 0.05) between taper instruments with a higher value for group I (205.3 ± 77.5 N) followed by II (185.2 ± 70.8 N), III (164.8 ± 48.9 N), and IV (156.7 ± 41.4 N). There was no difference (P > 0.05) between filling materials A (189.1 ± 66.3 N), B (186.3 ± 61.0 N), C (159.7 ± 69.9 N), and D (176.9 ± 55.2 N). Conclusions: Greater cervical wear using a #70/.12 file increased the root fracture susceptibility, and the tested filling materials were not able to restore resistance. 相似文献
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145.
Marco Aurélio Versiani Cássio José Alves de Sousa Antônio Miranda Cruz‐Filho Danyel Elias da Cruz Perez Manoel Damião Sousa‐Neto 《Dental traumatology》2008,24(1):136-139
Horizontal root fractures are uncommon, mainly occurring on the cervical and middle third of the root of permanent upper incisors. The diagnosis is essentially radiographic and requires different healing patterns, depending on some pre- and postinjury factors. The aim of this article was to report the clinical management and different healing types in three cases of horizontal root fractures on permanent dentition. In case 1, the pulp tissue was vital and no treatment was necessary. In case 2, a root canal treatment of the cervical fragment was necessary and in case 3, pulpal necrosis was verified and an apical surgery was performed. 相似文献
146.
Igor Bassi Ferreira Petean Erika Calvano Küchler Isadora Mello Vilarinho Soares Raquel Assed Bezerra Segato Léa Assed Bezerra da Silva Lívia Azeredo Alves Antunes Alessandro Guimarães Salles Leonardo Santos Antunes Manoel Damião de Sousa-Neto 《Journal of endodontics》2019,45(5):526-531
Introduction
The outcome of root canal treatment has been reported as intimately related to the host response. Genetic polymorphisms might be associated with apical periodontitis repair. The aim of this study was to evaluate the association between receptor activator of nuclear factor kappa B (RANK), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) genetic polymorphisms with persistent apical periodontitis (PAP) in Brazilian subjects.Methods
Subjects with at least 1 year of follow-up after nonsurgical root canal therapy were recalled. Sixty-four subjects with signs/symptoms of PAP and 86 subjects with root canal–treated teeth exhibiting healthy periradicular tissues (healed) were included. Genomic DNA was extracted from saliva and used for RANK (rs3826620), RANKL (rs9594738), and OPG (rs2073618) genotyping by real-time exact tests, and odds ratio were implemented using Epi Info 3.5.2 (Centers for Disease Control and Prevention, Atlanta, GA). A logistic regression analysis was also performed using the time of follow-up as the covariate. All tests were performed with an established alpha of 0.05 (P = .05).Results
An association between allele distribution and the polymorphism in RANK was observed. Subjects who carry the T allele had a lower risk of having PAP (P < .05). In RANKL polymorphism, the genotype distribution was statistically significant different between the PAP and healed groups (P = .05). The time of follow-up was associated with PAP (P < .05). In the logistic regression analysis using time as a covariant, RANK (P < .05) and RANKL (P < .05) were associated with PAP. The polymorphism rs2073618 in OPG was not associated with PAP (P > .05).Conclusions
These findings suggest that polymorphisms in RANK and RANKL genes are associated with PAP. 相似文献147.
148.
Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria 下载免费PDF全文
149.
Valeria Salinas Patricia Vega María Victoria Piccirilli Carla Chicco Carlos Ciraolo Silvia Christiansen Damián Consalvo Josefina Perez-Maturo Nancy Medina Dolores González-Morón Virginia Novaro Cecilia Perrone María del Carmen García Guillermo Agosta Walter Silva Marcelo Kauffman 《European journal of medical genetics》2019,62(11):103571
Malformations of cortical development are a frequent cause of drug-resistant Epilepsy and developmental delay. Hemimegalencephaly is a Malformation of cortical development characterized by enlargement of all or a part of one cerebral hemisphere. Germline and somatic mutation in genes belonging to the Mammalian Target of Rapamycin (mTOR) pathway has been identified in patients suffering from epilepsy secondary to Hemimegalencephaly and focal cortical dysplasia. We present here a patient suffering from severe neonatal Epilepsy since 3 h of life secondary to Hemimegalencephaly, requiring an anatomic hemispherectomy surgical procedure for seizure control, where by means of next-generation sequencing at an ultra-high depth coverage, we were able to identify a novel somatic mutation in the RHEB gene (NM_005614: c.119A > T: p. Glu40Val). The histopathological diagnosis was Cortical Dysplasia type IIB determined by the presence of dysmorphic neurons of variable size with nuclear alteration and balloon cells in the context of Hemimegalencephaly, which are similar to that have been demonstrated in hyperactivating RHEB models. This is the first report of a somatic mutation in RHEB gene in a patient suffering from Epilepsy secondary to Hemimegalencephaly. It highlights different current topics in the fields of genetics of Malformations of cortical development: a-somatic mosaicism is not uncommon in these neurodevelopmental disorders; b-the molecular diagnostic approach should involve the use of state-of-the-art methods and the sampling of different tissues; c-new findings might facilitate therapeutics discoveries while providing an improved understanding of normal brain development. 相似文献
150.