全文获取类型
收费全文 | 286688篇 |
免费 | 59374篇 |
国内免费 | 14578篇 |
专业分类
耳鼻咽喉 | 3524篇 |
儿科学 | 6857篇 |
妇产科学 | 2381篇 |
基础医学 | 35653篇 |
口腔科学 | 8706篇 |
临床医学 | 38816篇 |
内科学 | 49577篇 |
皮肤病学 | 9722篇 |
神经病学 | 21779篇 |
特种医学 | 10228篇 |
外国民族医学 | 87篇 |
外科学 | 34676篇 |
综合类 | 43641篇 |
现状与发展 | 61篇 |
一般理论 | 39篇 |
预防医学 | 21161篇 |
眼科学 | 6312篇 |
药学 | 27902篇 |
271篇 | |
中国医学 | 16405篇 |
肿瘤学 | 22842篇 |
出版年
2024年 | 769篇 |
2023年 | 3125篇 |
2022年 | 7949篇 |
2021年 | 11436篇 |
2020年 | 12861篇 |
2019年 | 16478篇 |
2018年 | 16410篇 |
2017年 | 17634篇 |
2016年 | 17891篇 |
2015年 | 21325篇 |
2014年 | 23392篇 |
2013年 | 23984篇 |
2012年 | 21536篇 |
2011年 | 22968篇 |
2010年 | 22499篇 |
2009年 | 16601篇 |
2008年 | 15275篇 |
2007年 | 13764篇 |
2006年 | 13087篇 |
2005年 | 11453篇 |
2004年 | 8130篇 |
2003年 | 7728篇 |
2002年 | 6661篇 |
2001年 | 5595篇 |
2000年 | 4656篇 |
1999年 | 3580篇 |
1998年 | 2006篇 |
1997年 | 1939篇 |
1996年 | 1518篇 |
1995年 | 1378篇 |
1994年 | 1152篇 |
1993年 | 708篇 |
1992年 | 841篇 |
1991年 | 689篇 |
1990年 | 623篇 |
1989年 | 514篇 |
1988年 | 466篇 |
1987年 | 440篇 |
1986年 | 330篇 |
1985年 | 271篇 |
1984年 | 134篇 |
1983年 | 100篇 |
1982年 | 69篇 |
1981年 | 59篇 |
1980年 | 43篇 |
1979年 | 81篇 |
1978年 | 37篇 |
1975年 | 40篇 |
1974年 | 53篇 |
1973年 | 54篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
涎腺导管内癌(intraductal carcinoma,IDC)是一种主要发生在腮腺,在导管内或囊内生长为主的罕见肿瘤,但也可伴浸润性生长,生物学行为相对惰性。具有独特的形态学、免疫表型及分子遗传学特征。主要包括4种亚型:闰管型、顶浆分泌型、闰管-顶浆分泌混合型和嗜酸型。闰管型多数存在NCOA4-RET融合,个别存在STRN-ALK融合;混合型存在TRIM27-RET融合,顶浆分泌型具有PIK3CA和HRAS突变或TP53缺失;嗜酸型具有TRIM33-RET融合或BRAF V600E突变。目前多数观点认为与涎腺导管癌不同,即使存在浸润,仍具有良好的预后,罕见复发和淋巴结转移,无远处转移。因此精准诊断对于临床治疗的选择极其重要。 相似文献
72.
73.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
74.
75.
目的 通过阿霉素(Dox)复制大鼠慢性心力衰竭(CHF)模型,观察Liguzinediol对CHF大鼠心功能的影响。方法 通过血流动力学观察Liguzinediol对Dox(腹腔注射,2 mg/kg)诱导的CHF大鼠左心室内压最大上升/下降速率(±dp/dtmax)、左心室内压(LVSP)、动脉收缩压(ASP)、动脉舒张压(ADP)和心率(HR)的变化;观察Liguzinediol对血清一氧化氮(NO)、一氧化氮合成酶(NOS)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)以及血浆中丙二醛(MDA)的影响。结果 Liguzinediol能增加LVSP、+dp/dtmax、ASP、ADP、AP、HR,降低-dp/dtmax(P<0.05~0.01);降低NO、iNOS以及MDA的浓度,同时增强了SOD的活性(P<0.05~0.01);抑制IL-6和TNF-α的生成(P<0.05~0.01)。结论 Liguzinediol可明显改善Dox诱导的CHF大鼠血流动力学指标,减少模型大鼠炎症因子的释放以及抑制氧自由基的生成。 相似文献
76.
Wei Zhang Zheng Li Feng-Qing Xu Ya-Shuo Ren Shuang-Wang Xu Tong-Sheng Wang 《Journal of Asian natural products research》2019,21(5):426-434
Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP+) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.
77.
Matrine,oxymatrine, and compound Kushen injection from the roots of Sophora flavescens: an overview of their anticancer activities
下载免费PDF全文
![点击此处可从《中国药学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In the present review, we updated current information on the chemistry, contents, and anticancer properties of matrine (MT), oxymatrine (OMT), and compound Kushen injection (CKI). The anticancer properties were focused on lung, breast, and liver cancer cells because they are most susceptible. Sources of information were from Google, Google Scholar, PubMed, PubMed Central, Science Direct, PubChem, J-Stage, Directory of Open Access Journals (DOAJ), and China National Knowledge Infrastructure (CNKI). Reference was also made on botanical websites, such as Flora of China and World Flora Online. MT and OMT are dominant quinolizidine alkaloids from the roots of Sophora flavescens (Kushen) of the family Fabaceae. Against lung, breast, and liver cancer cells, MT and OMT inhibit cell proliferation; induce cell cycle arrest, apoptosis, and autophagy; restrict angiogenesis; and inhibit cell metastasis, invasion, and migration. The processes involve various molecular targets and signaling pathways. CKI is a traditional Chinese medicine (TCM) composed of root extracts of S. flavescens and Smilax glabra (Baituling) of the family Smilacaceae. With MT and OMT as major components, CKI has been approved for the treatment of cancer in China more than 20 years ago. In recent years, systematic reviews and meta-analysis have been undertaken to evaluate the anticancer effects of CKI. When CKI is used alone and in combination with chemotherapy of western medicine, there is much to be learned concerning their interactions besides their individual and integrated efficacy. Some perspectives of MT, OMT, and CKI are discussed, and their suggestions for future research are provided. 相似文献
78.
79.
80.