Preparation of Iron Carbon Composite Material by Extracting Iron from Bauxite Residue and Its Adsorption of Heavy Metal Cd(II)

Bulletin of Environmental Contamination and Toxicology - An effective method of iron extraction from bauxite residue was explored, and iron was used to prepare iron carbon composite material, which...     

隆突性皮肤纤维肉瘤20例临床病理分析

20例隆突性皮肤纤维肉瘤临床特点为发生于真皮内、病程长、常反复局部复发。组织学特征为梭形瘤细胞围绕小血管排列成车辐状结构且遍及整个瘤体;瘤细胞成分单一、核轻度异型、核分裂象少见;瘤体常包裹较多脂肪细胞和皮肤附件;瘤组织常向皮下脂肪呈树枝状浸润性生长。本文介绍了新近的色素型和纤维肉瘤型两个亚型。     

兔中性粒细胞防御素对HL—60细胞毒性及对病毒的直接灭活作用

本研究从新西兰家兔腹腔渗出中性粒细胞溶酶体内提取酸溶性组分，经制备性ＡＵ－ＰＡＧＥ获得纯化的防御素（ＮＰ１和ＮＰ２），ＳＤＳ－ＰＡＧＥ测定分子量为３ｋｄ左右。以ＨＬ－６０细胞作靶细胞，当ＮＰ１或ＮＰ２在１００μｇ／ｍｌ浓度时，可杀死６０％以上的ＨＬ－６０细胞。ＮＰ１（２６０μｇ／ｍｌ）还可直接灭活单纯疱疹病毒Ｉ型和乙型流感病毒，分别使病毒感染滴度降度９８．２％和９０％。本研究结果提示，中性粒细胞可     

Persistent Dysregulation of IgA Production and IgA Nephropathy in the B6C3F1 Mouse Following Withdrawal of Dietary Vomitoxin (Deoxynivalenol)

To assess whether vomitoxin-induced dysregulation of IgA productionand IgA nephropathy are reversible, relevant immunologic parameterswere compared among experimental groups of B6C3F1 mice thatwere fed: (1) 25 ppm vomitoxin in AIN-76A semipurified dietfor 24 weeks (treatment group), (2) 25 ppm vomitoxin for 8 weeksand then control diet for 16 weeks (withdrawal group), and (3)control diet for 24 weeks (control group). Levels of serum IgAand microhematuria index in the treatment group were elevatedafter 4 to 8 weeks and continued to increase with further vomitoxinexposure. IgA immune complexes and mesangial IgA deposition,as quantitated by interactive laser cytometer image analysis,were also increased with toxin exposure at Weeks 8, 16, and24, whereas IgM, IgG, and complement component C3 depositionwere unaffected or depressed. Serum IgA, microhematuria index,and mesangial IgA deposition in withdrawal mice remained elevatedover those of the controls at Weeks 16 and 24 but were lessthan those of the treatment group. Cell recovery from Peyer'spatches (PP) as well as the percentages of IgA⁺ and CD4⁺ cellsin PP and spleen at Weeks 16 and 24 were greater in treatmentmice than in controls, but only the percentage of IgA⁺ cellsin PP was elevated in the withdrawal mice at these the sametime points. When IgA secretion by unstimulated and LPS-stimulatedsplenic lymphocytes was used as the measure of systemic production,it was elevated in both treatment and withdrawal mice at Weeks16 and 24. The results indicated that experimental dysregulationof IgA production and IgA nephropathy persisted up to 4 monthsafter a discrete period of dietary vomitoxin exposure, but thatthe severity of these effects did not increase in a progressivefashion.     

Influence of growth hormone-insulin-like growth factor Ⅰ axis on normal pregnancy

Objective To investigate the role of growth hormone-insulin-like growth factor Ⅰ (IGF-Ⅰ) axis in normal pregnancy. Methods Totally, 116 normal pregnant women were recruited from January 1997 to June 1998, with 20 normal nonpregnant women as controls. Maternal growth hormone (GH) and IGF-Ⅰ concentrations were assayed by RIA and enzyme-linked immunosorbent assay, respectively. Results Maternal serum levels of GH increased throughout gestation, reached a peak at 25 weeks of pregnancy and remained fairly high (χ[2]=40.458, P<0.0001).There was a significant difference between samples at 5-9 week gestational age and the controls (3.45 μg/L vs 1.61 μg/L, P<0.05). The maternal serum levels of IGF-Ⅰincreased rapidly throughout gestation from 29-week gestation and reached a peak of 188.86 μg/L at term delivery (χ[2]=50.224, P<0.0001). Conclusions Maternal GH levels increased progressively throughout gestation, which correlated with fetal growth. Maternal GH may regulate nutrition supply among mother, placenta and the fetus and play an important role in transporting nutritional substrates by the placenta. The maternal IGF-Ⅰin the third trimester may promote fetal growth and placental functions.     

肝移植后肝窦内皮细胞损伤的研究

目的 探讨肝移植后再灌注损伤和排斥反应时,肝窦内皮细胞的变化。方法 利用抗肝窦内皮细胞的单克隆抗体对大鼠肝移植后定期采取的肝组织标本染色。结果 对照组（LEW－LEW）于第4天在肝窦壁内可见ICAM－1的强染色,但是昆布氨酸、第Ⅷ因子相关抗原在实验基间均未见到。高度排斥反应组（ACI－LEW）移植后第1在开始发现ICAM－1的强染色。中度排斥反应组（BN－LEW）移植后第1天开始发现ICAM－1的强染色,移植后1个月开始肝窦壁出现第Ⅷ因子相关抗原。结论 说明慢性排斥反应引起的肝损伤,不仅是以肝动脉为中心的血管损伤,同时也损伤肝窦内皮细胞。