Ischemia-driven target vessel revascularization after-primary percutaneous coronary intervention: patients at risk and their outcomes

Clinical and angiographic correlates of ischemia-driven target vessel revascularization (ITVR) in patients undergoing primary percutaneous coronary interventions (PCI) are currently less well known. Accordingly, we examined 2,981 patients enrolled in different Primary Angioplasty in Myocardial Infarction trials, who underwent primary PCI to evaluate risk factors and outcomes of individuals requiring subsequent ITVR. At 6 months, ITVR was required in 321 patients (11%). Compared to the cohort without ITVR, patients requiring ITVR were younger (P=0.036), females (P=0.018), and more likely to have systolic blood pressure >100 mmHg on presentation (P=0.022), family history of premature coronary artery disease (P=0.035), and postprocedure dissection (P=0.001). In contrast, Killip Class >I on presentation (P=0.05), left circumflex as infarct-related artery (P=0.022), and the use of ticlopidine (P=0.044) and stents (p=0.057) were less frequent among ITVR patients. Multivariate analysis identified younger age (for each 10-year decrease, odds ratio [OR], 1.18; 95% confidence interval [CI], 1.06-1.32), female gender (OR: 1.41, 95% CI: 1.05-1.89), and final dissection (OR: 1.69, 95% CI: 1.23-2.33) as independent risk factors for ITVR. In-hospital reinfarction (P < 0.001) was increased and at 6 months remained higher in ITVR patients; in-hospital and 6-month mortality did not differ between the two groups. Our study identifies the incidence, risk factors, and outcomes of patients requiring ITVR after primary PCI. Importantly, our data suggest that no increase in mortality occur, if ITVR is promptly performed to treat recurrent ischemia after primary PCI.     

严重急性呼吸综合征200例死亡危险因素分析

目的 :分析严重急性呼吸综合症 (SARS)的临床特点 ,分析其死亡危险因素。方法 :参考我院 2 0 0 3年 3～ 6月收治的 2 0 0例SARS患者的临床资料 ,选取一些可能对死亡有影响的因素进行回顾性分析 ,采用Mantel Haenszelχ2 检验和t检验预测其危险程度的大小。结果 :性别、年龄、合并糖尿病、合并心脑血管病、合并慢性呼吸系统疾病、合并恶性肿瘤、发病早期最高体温、发病早期最低经皮血氧饱和度、发病早期外周血白细胞计数减少、发病早期血小板减少、发病早期血红蛋白减少、发病早期外周血CD3降低、外周血CD4降低、外周血CD8降低等 14个临床因素的相对危险度 (RR)分别为 2 .6 39、12 .176、4 .12 4、5 .1、3.0 5、3.6 80、3.92 1、4 7.2 73、0 .35 3、16 .718、10 .737、9.2 86、19.0 77、14 .16 7;95 %CI分别为 0 .6 79～ 10 .2 5 2、2 .5 4 5～ 5 8.2 6 4、1.12 0～ 15 .187、1.4 74～ 17.6 4 3、0 .334～ 2 7.82 0、0 .392～ 35 .5 4 6、0 .82 5～ 18.6 32、5 .84 9～ 382 .0 6 2、2 .991～38.5 4 0、4 .16 4～ 6 7.117、0 .0 74～ 1.6 80、1.16 5～ 73.981、2 .389～ 15 2 .30 8、2 .389～ 15 2 .30 8。结论 :与死亡有关的危险因素共有 9个 ,按危险性的大小排列依次为 :发病早期SPO2 降低、外周血CD4降     

血清胱蛋白酶抑制剂C诊断老年高血压早期肾损害

目的 观察老年高血压患者血清胱蛋白酶抑制剂C(Cyst-c)浓度对检出早期肾损害的价值。方法 对412例老年高血压患者同时测血Cyst-c和血肌酐(Cr)浓度，并与正常对照组对照。结果412例老年高血压患者中早期肾损害197例(占47.82％)，肾功能不全24例(5.82％)，肾功能正常191例(46.36％)。在早期肾损害组：血Cyst-c浓度明显高于对照组[(2.3±0.8 vs 0.9±0.2)mg／L，P＜0.01)]，而血Cr浓度两组无显著性差异[(86.6±12.7 vs 81.0±10.5)μmol／L，P＞0.05]。结论 老年高血压患者中，早期肾损害占47.82％，很常见。血Cyst-c能检出血Cr不能检出的早期肾损害。     

支架置入治疗气管恶性狭窄

目的 探讨气管内支架留置的方法,及观察自胀式金属内支架在气管恶性狭窄中的疗效。方法 12例患者全部采用在透视下．经口、喉、气道内支架留置术。结果 患者呼吸困难在支架留置后即刻改善。l2例均获成功．没有技术上失败。结论 气管恶性狭窄的内支架留置术安全、有效．能明显提高患者的生活质量。     

Screening, diagnosis and management of early syphilis in genitourinary medicine clinics in the UK

New diagnoses of syphilis in the UK increased eight-fold between 1997 and 2002. This study, conducted in 2002, demonstrated that 31% of clinics were not confident of their expertise to obtain an adequate specimen for dark ground microscopy (DGM), and 35% were not confident of their expertise to detect treponemes on DGM. In all, 64% of clinics had observed adherence problems in HIV-positive patients treated with parenteral regimens, as against 42% with oral regimens. Also, 51% of clinics waited more than a week for the results of initial serological tests for syphilis, and 88% of clinics waited more than a week for confirmatory test results. Other concerns include the failure to perform syphilis serology consistently whenever HIV-positive patients were at risk, and the widespread use of doxycycline as a therapy for syphilis in HIV-positive patients despite concerns that this is not known to be fully treponemicidal in cerebrospinal fluid.     

老年冠心病患者冠状动脉内支架术的疗效研究

目的：探讨老年冠心病患冠状动脉内支架术的近期疗效和对远期预后的影响。方法：2000年6月-2002年6月连续240例冠心病患行选择性冠状动脉内支架术，其中86例年龄＞65岁(A组)，154例＜65岁(B组)，比较两组支架术成功率及远期随访结果。结果：A组中84例支架术成功(97．7％)，并发症率9．30％。B组中150例支架术成功(97．4％)，并发症率4．55％，两组差异均无显性(P＞0．05)。随访12．5土6．5个月，随访率95．7％。A、B两组的心功能改善(54．7％和51．9％)、心绞痛复发(30．2％和36．4％)、再入院(18．6％和20．1％)、总心脏事件发生率(18．6％和22．7％)及无心脏事件存活率(86．0％和85．1％)均无显性差异(P＞0．05)。结论：老年患冠状动脉内支架术安全、成功率高，且远期预后良好。     

Combined splenocaval or mesocaval C shunt and portoazygous devascularization in the treatment of portal hypertension: analysis of 150 cases

BACKGROUND: Portal hypertension is a common disease and its major surgical therapeutic approaches include devascularization and shunting. This study was undertaken to investigate the effects of combined splenocaval or mesocaval C shunt and portoazygous devascularization (combined procedures) on portal hypertension. METHODS: The clinical data of 150 patients with portal hypertension who had undergone combined procedures at the First Affiliated Hospital of Zhengzhou University from May1990 to May 2003 were analyzed retrospectively. RESULTS: The mean free portal pressure (FPP) was 25.6±1.83 mmHg, 18.0±2.07 mmHg and 18.4±2.19 mmHg before operation, after splenectomy plus splenocaval or mesocaval C shunt, and combined procedures, respectively. There was no operative death in all patients. The 1-7 year follow-up of 100 patients showed rebleeding in 3 patients, encephalopathy in 4, thrombosis of artificial vascular graft in 3, and dying from liver failure in 2. CONCLUSIONS: The combined procedures can not only decrease portal pressure but also preserve hepatic blood flow to some extent. It may be one of the best choices for treating portal hypertension in China.