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61.
目的研究嗜酸乳杆菌对人舌癌细胞Tca8113增殖及细胞周期的影响。方法体外培养Tca8113细胞,分别将不同稀释度(原液和4、16倍稀释)的嗜酸乳杆菌上清液、灭活菌液和无细胞提取物与Tca8113细胞共培养,采用倒置显微镜观察细胞形态并行细胞计数,磺酰罗丹明B(SRB)法测定细胞增殖率,流式细胞术分析嗜酸乳杆菌各组分对Tca8113细胞增殖及细胞周期的影响,激光扫描共聚焦显微镜(CLSM)检测细胞内自由基和Ca2+含量。结果嗜酸乳杆菌各组分作用于Tca8113细胞48 h后,在倒置显微镜下观察,细胞由菱形、多角形、铺路石状变为细长形。细胞计数与SRB实验分析:在不同稀释度同一培养时间与不同培养时间同一稀释度培养条件下,嗜酸乳杆菌各组分均可明显抑制Tca8113细胞增殖,抑制力随稀释度增加而降低,随培养时间延长而增强。流式细胞术分析:嗜酸乳杆菌各组分作用Tca8113细胞48 h后,细胞增殖指数降低(P<0.01)。CLSM检测:嗜酸乳杆菌各组分作用Tca8113细胞48 h后细胞内自由基和Ca2+含量均升高(P<0.01)。结论嗜酸乳杆菌代谢产物、灭活菌液、无细胞提取物均可抑制Tca8113细胞增殖,可能与菌体及其代谢产物引起细胞内自由基含量增多、Ca2+超载有关。 相似文献
62.
Dai-Jun Wang Ming-Zhe Zheng Ye Gong Qing Xie Yin Wang Hai-Xia Cheng Ying Mao Ping Zhong Xiao-Ming Che Cheng-Chuan Jiang Feng-Ping Huang Kang Zheng Shi-Qi Li Yu-Xiang Gu Wei-Min Bao Bo-Jie Yang Jing-Song Wu Li-Qian Xie Hai-Liang Tang Hong-Da Zhu Xian-Cheng Chen Liang-Fu Zhou 《International journal of clinical and experimental pathology》2013,6(5):878-888
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Chih‐Cheng Huang MD PhD Tai‐Lin Huang MD Hsuan‐Chih Hsu MD Hui‐Chun Chen MD Hsin‐Ching Lin MD Chih‐Yen Chien MD Fu‐Min Fang MD PhD Hsueh‐Wen Chang PhD Nai‐Wen Tsai MD PhD Wen‐Neng Chang MD Shu‐Fang Chen MD Tzu‐Kong Lin MD PhD Teng‐Yeow Tan MD Chuang‐Rung Chang PhD Hung‐Chen Wang MD Wei‐Che Lin MD PhD Cheng‐Hsien Lu MD MSc 《Muscle & nerve》2013,47(3):344-350
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Pluskiewicz W Halaba Z Chełmecka L Drozdzowska B Sońta-Jakimczyk D Karasek D 《Ultrasound in medicine & biology》2004,30(7):893-898
The skeletal growth in a course of acute lymphoblastic leukemia (ALL) may be affected, and the aim of the longitudinal study was to assess the skeletal status in survivors of (ALL). The studied population consisted of 38 subjects (17 female and 21 male) measured at the age of 13.9 +/- 3.8 years (5.7 +/- 2.9 years after completion of the therapy, 11.0 +/- 14.4 years after diagnosis) and 2 years earlier; compared with 1402 controls (628 female and 774 male). Patients and controls did not differ significantly in regard to age, height or weight. Skeletal status was assessed by quantitative ultrasound (US) measurements at the hand phalanges using the DBM Sonic 1200, which measures amplitude-dependent speed-of-sound, Ad-SoS (m/s). rms CV% was 0.43%. Mean baseline Ad-SoS value in patients was 1990 +/- 76 m/s and, at second measurement, 2045 +/- 86 m/s (p < 0.000001). In 31 patients, Ad-SoS increased and, in one patient, decreased more than the value of the least significant change. In controls, mean Ad-SoS values were 1973 +/- 64 m/s (baseline) and 2016 +/- 86 m/s (follow-up) and did not differ significantly vs. baseline values in patients. At second measurement, Ad-SoS in controls was significantly lower than in patients (p < 0.05). In five patients with low baseline Ad-SoS values, bone mineral density (BMD) at the spine using DPX-L was estimated; baseline mean BMD was 0.95 +/- 0.11 g/cm2, Z-score was 1.25 +/- 0.97 and, at second measurement, 1.16 +/- 0.07 g/cm2, Z-score was 0.23 +/- 0.43. A significant increase in BMD (p < 0.01) and Z-score (p < 0.05) was noted. In patients, Ad-SoS correlated significantly with age, period after completion of the therapy, body size and Tanner stages (r ranged from 0.43 to 0.83, p ranged from 0.0001 to 0.05). It can be concluded that skeletal status assessed by quantitative US at the hand phalanges in survivors of ALL improved significantly over the period of observation. 相似文献
66.
Relapsed infant MLL‐rearranged acute lymphoblastic leukemia with additional genetic alterations 下载免费PDF全文
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Aleksandra Górska Marta Gruchała-Niedoszytko Marek Niedoszytko Agnieszka Maciejewska Marta Chełmińska Marcin Skrzypski Bartosz Wasąg Małgorzata Kaczkan Magdalena Lange Bogusław Nedoszytko Ryszard Pawłowski Sylwia Małgorzewicz Ewa Jassem 《Archivum immunologiae et therapiae experimentalis》2016,64(6):497-503
69.
Feng Li Wenqiang Guo Li Wu Tianjiao Zhu Qianqun Gu Dehai Li Qian Che 《Archives of pharmacal research》2018,41(1):30-34
Three new diketopiperazine derivatives (DKPs), saroclazines A–C (1–3) along with three known DKPs (4–6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A–B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1–3) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 µM. 相似文献
70.