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Tamar Pincus Clare Miles Robert Froud Martin Underwood Dawn Carnes Stephanie JC Taylor 《BMC medical research methodology》2011,11(1):14
Background
Current methodological guidelines provide advice about the assessment of sub-group analysis within RCTs, but do not specify explicit criteria for assessment. Our objective was to provide researchers with a set of criteria that will facilitate the grading of evidence for moderators, in systematic reviews. 相似文献994.
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Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the occurrence and recurrence of orofacial clefts, using observational and non‐randomized interventional designs. While preventive effects of folic acid on orofacial clefts are commonly reported, the evidence remains generally inconsistent. This paper reviews the findings of the main studies of the effects of folic acid on orofacial clefts, summarizes study limitations, and discusses research needs with a focus on studying the effects of high dosage folic acid on the recurrence of oral clefts using a randomized clinical trial design. The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts. 相似文献
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JAM Hunfeld J Passchier CW Perquin AAJM Hazebroek-Kampschreur LWA van Suijlekom-Smit & JC van der Wouden 《Cephalalgia : an international journal of headache》2001,21(3):201-206
The differences in quality of life and school absence were studied in one hundred adolescents from the open population who had reported chronic headache or chronic, physically unexplained, pain at other locations. The adolescents kept a 3-week diary about their pain and completed a quality of life questionnaire. Of all chronic pain sufferers in this study, it was the adolescents with headache who showed the least frequent pain, but they reported the poorest quality of life and the largest school absence due to their pain. Adolescents with headache or adolescents with back pain showed the highest negative correlations between pain parameters and quality of life. Headache sufferers showed highly negative relationships between pain parameters and most quality of life domains (median r = -0.46), and only in headache sufferers did this involve both intensity and frequency of pain. Qualitative studies are needed to reveal the background to these differences. 相似文献
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Catherine L Wilson Stephen JC Hearps Emma J Tavender Natalie T Phillips Ben Lawton Frances Kinnear Amie Beattie Hugh Mitenko Russell Young Joanne Cole Amit Kochar Shane George Stephen SS Teo Thomas Georgeson Adam Michael Ashes Mukherjee Alex King Lalith Gamage Peter Archer Corey Cassidy Arjun Rao Deepali Thosar Meredith L Borland Franz E Babl 《Emergency medicine Australasia : EMA》2021,33(1):157-160
999.
Neeraj Sethi Oliver Dale Sivakumar Vidhyadharan Suren Krishnan Andrew Foreman JC Hodge 《The international journal of medical robotics + computer assisted surgery : MRCAS》2020,16(3)
The advent of transoral robotic surgery (TORS) has allowed transoral approaches for parapharyngeal space (PPS) tumours to be re‐evaluated. It provides enhanced visualisation and instrument access for appropriate tumours. We describe a specific technique, TORS narrow‐field oropharyngectomy, that is ideal for benign PPS tumours which have been violated by intra‐oral biopsy or incision and drainage. This allows the contaminated, overlying oropharyngeal mucosa to be resected en‐bloc with the PPS tumour, reducing the risk of local recurrence. This technique provides a window into the PPS, improving visualisation of underlying neurovascular structures as well as the tumour. This reduces the risk of tumour spillage and leads to superior vascular access and haemorrhage control. This technique is only applicable to PPS tumours that are appropriate for transoral approaches and is specifically designed for those selected patients that have been placed at risk of seeding or local scarring by intra‐oral procedures prior to definitive resection. We present two such cases: a 38‐year‐old male with a PPS inflammatory cyst and a 66‐year‐old female with a PSS pre‐styloid Schwannoma. 相似文献