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61.
62.
OCT4: a novel biomarker for dysgerminoma of the ovary 总被引:7,自引:0,他引:7
63.
Mohammad Qrimli MD Hamid Ebadi MD Ari Breiner MD Hafsah Siddiqui MD Majed Alabdali MD Alon Abraham MD Leif E. Lovblom Bruce A. Perkins MD Vera Bril MD 《Muscle & nerve》2016,53(4):538-544
Introduction: High‐resolution ultrasonography (HRU) is a novel method that provides morphological information about peripheral nerves. We aimed to determine reference values for nerve cross‐sectional area (CSA) on HRU. Methods: One hundred healthy volunteers had HRU of median, radial, ulnar, fibular, tibial, sural, and superficial fibular nerves at defined sites. The CSA was measured and the effects of age, gender, and body mass index (BMI) were evaluated. Results: CSA values in healthy subjects are described. CSA is larger in lower limb motor nerves than in sensory nerves at similar sites, and the CSA tends to be symmetrical. The strongest effect on CSA was for age, although gender and BMI had some effects. Conclusions: This study provides normative values for HRU, and it suggests that further research with age‐ and gender‐specific distributions must be a key priority in the development of HRU for use as a diagnostic test for peripheral nerve diseases. Muscle Nerve 53 : 538–544, 2016 相似文献
64.
Papillary fibroelastoma is a rare primary tumor of the heart valves. This lesion can occur on any of the valves or endothelial surface of the heart and has been detected by echocardiography, by cardiac catheterization, during open heart operations for other conditions, and at autopsy. Because of the potential for comorbidities, this tumor should be removed. We present the case of an elderly man with a diagnosis of severe mitral valve regurgitation and moderate tricuspid valve regurgitation who was suspected to have a tricuspid valve vegetation. Mitral valve replacement, tricuspid valve repair, and excision of the lesion were performed successfully. A histologic examination of the vegetation confirmed it to be a papillary fibroelastoma. We present this case to emphasize the rarity of this tumor and the importance of a correct diagnosis to avoid delaying its prompt and definitive management. 相似文献
65.
Mohammed AlSheef Mastourah Alotaibi Abdul Rehman Z. Zaidi Areej Alshamrani Aroub Alhamidi Syed Ziauddin A. Zaidi Noor Alanazi Sarah Alhathlool Ohoud Alarfaj Mohammed AlHazzaa Ghaydaa Kullab Amany Alboghdadly Amani Abu-Shaheen 《Saudi medical journal》2020,41(10):1063
Objectives:To identify the epidemiologic profile of cerebral vein thrombosis (CVT) among fasting women using oral contraceptive pills (OCPs) during the holy month of Ramadan.Methods:This retrospective study was conducted on all patients diagnosed with CVT and using OCPs from records at a tertiary care hospital in Riyadh, Saudi Arabia during 2016-2017. The study participants were categorized into 2 groups (an intermittently fasting group during the holy month of Ramadan and a non-fasting group).Results:Out of 108 female patients with CVT, 36.1% were secondary to OCP, of whom 41% participants were fasting. The most affected site was the transverse sinus. Holocephalic headache was more common amongst fasting group (68.8%) compared to non-fasting group (30.4%) (p=0.025). Dehydration (p=0.003) amongst the fasting group and protein S deficiency (p=0.027) in the non-fasting group were identified as the 2 prominent risk factors. Unfractionated heparin was the most common anticoagulant therapies used during the initiation phase for non-fasting (36.4%) and fasting groups (50%).Conclusion:All women who are using OCP should undergo formal written risk assessments for factors of CVT. Our study suggests that the negative effects of OCPs use might outweigh its benefits; thus, it should be prescribed with caution, more so in fasting patients. 相似文献
66.
BACKGROUND: Renal ischemia/reperfusion (I/R) injury is associated with delayed graft function and decreased long-term allograft function. However, most experimental studies evaluating renal I/R injury have focused on acute events after ischemia. T cells are potential candidates to link preservation injury, alloimmunity, and fibrosis. We hypothesized that severe renal I/R injury would generate long-term kidney damage and immune changes. METHODS: C57BL/6 mice underwent 60 minutes of warm unilateral I/R injury or sham surgery and were studied for 6 weeks. Serum creatinine, renal histology, and albumin excretion were measured. Phagocyte infiltration, CD4+ infiltration, renal cytokine expression, and splenic lymphocyte intracellular cytokine production were also measured in mice at 6 weeks. RESULTS: Serum creatinine levels rose following 60 minutes of unilateral I/R injury compared to sham mice. Histologic analysis of ischemic kidneys at 6 weeks revealed a pronounced loss of tubular architecture and infiltration of inflammatory cells. Phagocyte and CD4+ T-cell infiltration were significantly increased in ischemic kidneys. This was accompanied by a significant increase in interleukin (IL)-1beta and regulated upon activation, normal T-cell expressed and secreted (RANTES) expression. Despite similar splenic CD4 and CD8 numbers, intracellular cytokine staining of T cells revealed a significant increase in interferon-gamma (IFN-gamma) in I/R injury mice compared to sham mice. CONCLUSION: Persistent renal and extrarenal immune responses occur after a single episode of severe I/R injury. These immune processes resulting from injury could in turn have long-term consequences on progression of renal disease in transplanted and native kidneys. 相似文献
67.
Mahmut Ilker Yilmaz Mutlu Saglam Juan Jesus Carrero Abdul R. Qureshi Kayser Caglar Tayfun Eyileten Alper Sonmez Yusuf Oguz Ismail Aslan Abdulgaffar Vural Mujdat Yenicesu Peter Stenvinkel Bengt Lindholm Jonas Axelsson 《Clinical transplantation》2009,23(2):241-248
Abstract: Endothelial dysfunction is strongly linked to cardiovascular disease and outcome of patients with chronic kidney disease. We hypothesized that decreased inflammatory activity and increased adiponectin following transplantation could be one mechanism for a better endothelial health. Fifty-eight living donor kidney transplant non-diabetic recipients, 31 (23 male, 29 ± 5 yr) on cyclosporine A and 27 (10 male, 26 ± 5 yr) on tacrolimus immunsupression, were studied longitudinally. Visfatin, adiponectin, high sensitive C-reactive protein (hsCRP) levels, brachial artery flow mediated dilatation (FMD) and nitroglycerine mediated dilatation were measured before transplantation and on the 30th and 90th day after transplantation. Pre-transplantation visfatin, adiponectin and FMD values of patients were significantly higher than those of the controls (p < 0.001 for all). All values decreased significantly 30 and 90 d post-transplantation. Plasma visfatin and adiponectin, correlated negatively with FMD levels 90 d both before and after kidney transplantation (p < 0.001 for both). Endothelial function improved during the first month after transplantation, and the degree of improvement correlated to reductions in circulating visfatin, adiponectin and hsCRP levels. Of interest, the intracellular enzyme visfatin was the strongest predictor of FMD both before and after kidney transplantation and may thus reflect endothelial cell damage directly. 相似文献
68.
Behzad Einollahi Mahboob Lessan-Pezeshki Mohammad Hossein Nourbala Naser Simforoosh Vahid Pourfarziani Eghlim Nemati Mohsen Nafar Abbas Basiri Fatemeh Pour-Reza-Gholi Ahmad Firoozan Mohammad Hassan Ghadiani Khadijeh Makhdoomi Ali Ghafari Pedram Ahmadpour Farshid Oliaei Mohammad Reza Ardalan Atieh Makhlogh Hamid Reza Samimagham Jalal Azmandian 《International urology and nephrology》2009,41(3):679-685
Introduction Kaposi’s sarcoma (KS) is one of the most common tumors to occur in kidney recipients, especially in the Middle East countries.
Limited data with adequate sample size exist about the development of KS in living kidney recipients.
Methods Therefore, we made a plan for a multicenter study, accounting for up to 36% (n = 7,939) of all kidney transplantation in Iran, to determine the incidence of KS after kidney transplantation between 1984
and 2007.
Results Fifty-five (0.69%) recipients who developed KS after kidney transplantation were retrospectively evaluated with a median follow-up
of 24 (1–180) months. KS occurred more often in older age when compared to patients without KS (49 ± 12 vs. 38 ± 15 years,
P = 0.000). KS was frequently found during the first 2 years after transplantation (72.7%). Skin involvement was universal.
Furthermore, overall mortality rate was 18%, and it was higher in patients with visceral involvement compared to those with
mucocutaneous lesions (P = 0.01). However, KS had no adverse affect on patient and graft survival rates compared to those without KS. Forty-four patients
with limited mucocutaneous disease and four with visceral disease responded to withdrawal or reduction of immunosuppression
with or without other treatment modalities. Renal function was preserved when immunosuppression was reduced instead of withdrawn
in patients with and without visceral involvement (P = 0.001 and 0.008, respectively).
Conclusion The high incidence of KS in this large population studied, as compared to that reported in other transplant patient groups,
suggests that genetic predisposition may play a pathogenetic role. 相似文献
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