全文获取类型
收费全文 | 2526篇 |
免费 | 122篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 82篇 |
妇产科学 | 57篇 |
基础医学 | 274篇 |
口腔科学 | 54篇 |
临床医学 | 224篇 |
内科学 | 576篇 |
皮肤病学 | 39篇 |
神经病学 | 112篇 |
特种医学 | 33篇 |
外科学 | 383篇 |
综合类 | 50篇 |
一般理论 | 3篇 |
预防医学 | 313篇 |
眼科学 | 41篇 |
药学 | 280篇 |
中国医学 | 36篇 |
肿瘤学 | 85篇 |
出版年
2024年 | 8篇 |
2023年 | 28篇 |
2022年 | 90篇 |
2021年 | 134篇 |
2020年 | 51篇 |
2019年 | 99篇 |
2018年 | 90篇 |
2017年 | 74篇 |
2016年 | 92篇 |
2015年 | 82篇 |
2014年 | 126篇 |
2013年 | 160篇 |
2012年 | 172篇 |
2011年 | 194篇 |
2010年 | 117篇 |
2009年 | 88篇 |
2008年 | 154篇 |
2007年 | 131篇 |
2006年 | 118篇 |
2005年 | 112篇 |
2004年 | 126篇 |
2003年 | 95篇 |
2002年 | 64篇 |
2001年 | 33篇 |
2000年 | 33篇 |
1999年 | 30篇 |
1998年 | 17篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 11篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1974年 | 6篇 |
1973年 | 7篇 |
1972年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有2654条查询结果,搜索用时 0 毫秒
121.
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma 总被引:9,自引:0,他引:9
Howarth PH Babu KS Arshad HS Lau L Buckley M McConnell W Beckett P Al Ali M Chauhan A Wilson SJ Reynolds A Davies DE Holgate ST 《Thorax》2005,60(12):1012-1018
BACKGROUND: Tumour necrosis factor alpha (TNFalpha) is a major therapeutic target in a range of chronic inflammatory disorders characterised by a Th1 type immune response in which TNFalpha is generated in excess. By contrast, asthma is regarded as a Th2 type disorder, especially when associated with atopy. However, as asthma becomes more severe and chronic, it adopts additional characteristics including corticosteroid refractoriness and involvement of neutrophils suggestive of an altered inflammatory profile towards a Th1 type response, incriminating cytokines such as TNFalpha. METHODS: TNFalpha levels in bronchoalveolar lavage (BAL) fluid of 26 healthy controls, 42 subjects with mild asthma and 20 with severe asthma were measured by immunoassay, and TNFalpha gene expression was determined in endobronchial biopsy specimens from 14 patients with mild asthma and 14 with severe asthma. The cellular localisation of TNFalpha was assessed by immunohistochemistry. An open label uncontrolled clinical study was then undertaken in 17 subjects with severe asthma to evaluate the effect of 12 weeks of treatment with the soluble TNFalpha receptor-IgG1Fc fusion protein, etanercept. RESULTS: TNFalpha levels in BAL fluid, TNFalpha gene expression and TNFalpha immunoreative cells were increased in subjects with severe corticosteroid dependent asthma. Etanercept treatment was associated with improvement in asthma symptoms, lung function, and bronchial hyperresponsiveness. CONCLUSIONS: These findings may be of clinical significance in identifying TNFalpha as a new therapeutic target in subjects with severe asthma. The effects of anti-TNF treatment now require confirmation in placebo controlled studies. 相似文献
122.
Weisleder N Soumaka E Abbasi S Taegtmeyer H Capetanaki Y 《Journal of molecular and cellular cardiology》2004,36(1):121-128
Mice deficient in desmin, the muscle-specific member of the intermediate filament gene family, display defects in all muscle types and particularly in the myocardium. Desmin null hearts develop cardiomyocyte hypertrophy and dilated cardiomyopathy (DCM) characterized by extensive myocyte cell death, calcific fibrosis and multiple ultrastructural defects. Several lines of evidence suggest impaired vascular function in desmin null animals. To determine whether altered capillary function or an intrinsic cardiomyocyte defect is responsible for desmin null DCM, transgenic mice were generated to rescue desmin expression specifically to cardiomyocytes. Desmin rescue mice display a wild-type cardiac phenotype with no fibrosis or calcification in the myocardium and normalization of coronary flow. Cardiomyocyte ultrastructure is also restored to normal. Markers of hypertrophy upregulated in desmin null hearts return to wild-type levels in desmin rescue mice. Working hearts were perfused to assess coronary flow and cardiac power. Restoration of a wild-type cardiac phenotype in a desmin null background by expression of desmin specifically within cardiomyocyte indicates that defects in the desmin null heart are due to an intrinsic cardiomyocytes defect rather than compromised coronary circulation. 相似文献
123.
124.
Muhammad Irfan Sharjeel Waqas Ushtar Arshad Javed Akbar Khan Stanislaw Legutko Izabela Kruszelnicka Dobrochna Ginter-Kramarczyk Saifur Rahman Anna Skrzypczak 《Materials》2022,15(5)
Membrane fouling is a major hindrance to widespread wastewater treatment applications. This study optimizes operating parameters in membrane rotating biological contactors (MRBC) for maximized membrane fouling through Response Surface Methodology (RSM) and an Artificial Neural Network (ANN). MRBC is an integrated system, embracing membrane filtration and conventional rotating biological contactor in one individual bioreactor. The filtration performance was optimized by exploiting the three parameters of disk rotational speed, membrane-to-disk gap, and organic loading rate. The results showed that both the RSM and ANN models were in good agreement with the experimental data and the modelled equation. The overall R2 value was 0.9982 for the proposed network using ANN, higher than the RSM value (0.9762). The RSM model demonstrated the optimum operating parameter values of a 44 rpm disk rotational speed, a 1.07 membrane-to-disk gap, and a 10.2 g COD/m2 d organic loading rate. The optimization of process parameters can eliminate unnecessary steps and automate steps in the process to save time, reduce errors and avoid duplicate work. This work demonstrates the effective use of statistical modeling to enhance MRBC system performance to obtain a sustainable and energy-efficient treatment process to prevent human health and the environment. 相似文献
125.
126.
127.
Carina Venter Carlo Agostoni S. Hasan Arshad Miriam Ben-Abdallah George Du Toit David M. Fleischer Matthew Greenhawt Deborah H. Glueck Marion Groetch Nonhlanhla Lunjani Kate Maslin Alexander Maiorella Rosan Meyer Muraro Antonella Merryn J. Netting Bright Ibeabughichi Nwaru Debra J. Palmer Micheala P. Palumbo Graham Roberts Caroline Roduit Pete Smith Eva Untersmayr Lauren A. Vanderlinden Liam O’Mahony 《Pediatric allergy and immunology》2020,31(8):889-912
128.
129.
Jennifer Blanco Stephanie Gaines Jawad Arshad Johnathan M. Sheele 《The American journal of emergency medicine》2018,36(12):2340.e3-2340.e4
Fatal complications from illegal cosmetic injection of nonmedical-grade liquid silicone (polydimethylsiloxane) by unlicensed providers are becoming more common. Silicone embolization syndrome (SES) can rapidly progress to pneumonitis and diffuse alveolar hemorrhage. Prompt and aggressive management with high-dose steroids and lung-protective ventilation strategies to minimize acute respiratory distress syndrome (ARDS) can be lifesaving. We present the case of a patient presenting with abdominal pain and shortness of breath who quickly developed respiratory failure. The patient recently had received bilateral gluteal silicone injections from an unlicensed provider. 相似文献
130.