全文获取类型
收费全文 | 1096篇 |
免费 | 48篇 |
国内免费 | 37篇 |
专业分类
儿科学 | 36篇 |
妇产科学 | 29篇 |
基础医学 | 93篇 |
口腔科学 | 41篇 |
临床医学 | 476篇 |
内科学 | 117篇 |
皮肤病学 | 6篇 |
神经病学 | 46篇 |
特种医学 | 114篇 |
外科学 | 33篇 |
综合类 | 26篇 |
预防医学 | 45篇 |
眼科学 | 7篇 |
药学 | 48篇 |
中国医学 | 8篇 |
肿瘤学 | 56篇 |
出版年
2023年 | 5篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 18篇 |
2014年 | 18篇 |
2013年 | 37篇 |
2012年 | 16篇 |
2011年 | 13篇 |
2010年 | 30篇 |
2009年 | 39篇 |
2008年 | 27篇 |
2007年 | 36篇 |
2006年 | 22篇 |
2005年 | 23篇 |
2004年 | 29篇 |
2003年 | 28篇 |
2002年 | 30篇 |
2001年 | 38篇 |
2000年 | 26篇 |
1999年 | 38篇 |
1998年 | 92篇 |
1997年 | 88篇 |
1996年 | 80篇 |
1995年 | 67篇 |
1994年 | 50篇 |
1993年 | 58篇 |
1992年 | 19篇 |
1991年 | 27篇 |
1990年 | 27篇 |
1989年 | 23篇 |
1988年 | 34篇 |
1987年 | 11篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1980年 | 7篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1971年 | 2篇 |
1962年 | 1篇 |
1958年 | 2篇 |
排序方式: 共有1181条查询结果,搜索用时 15 毫秒
61.
经肛门内镜显微手术治疗直肠绒毛状腺瘤和早期直肠癌31例 总被引:8,自引:1,他引:8
目的探讨经肛门内镜显微手术(transanal endoscopicmic rosurgery,TEM)治疗直肠绒毛状腺瘤和早期直肠癌的疗效。方法1995年11月~2003年12月,我院行TEM治疗直肠肿瘤31例。全麻下根据肿瘤位置选择合适的体位,经肛门插入特殊的手术直肠镜,保持CO2充气状态,在立体视镜和腔镜系统下,采用针形电刀或5mm超声刀将直肠肿瘤完整切除(黏膜下或全层切除),手术创口在腔内连续缝合。结果31例直肠肿瘤均获完整切除,切缘均阴性。手术时间45~220min,平均95min;术中出血量0~180ml,平均40ml。手术并发症:暂时性排气失控2例,急性尿潴留1例,慢性阻塞性气道疾病急性发作1例,因服用阿斯匹林而出现继发性出血1例。术后病理分期:pT0期16例,pTis期2例,pT1期7例,pT2和pT3期各3例。31例随访2~92个月,平均23个月,肿瘤无原位复发。结论TEM是治疗直肠绒毛状腺瘤和早期直肠癌的一种安全、有效的微创手术方法。 相似文献
62.
Background
Interferon gamma (IFNγ) is a pro-inflammatory cytokine, which may be up-regulated after trauma to the peripheral or central nervous system. Such changes include reactive gliosis and synaptic plasticity that are considered important responses to the proper regenerative response after injury. Also, IFNγ is involved in the upregulation of the major histocompatibility complex class I (MHC class I), which has recently been shown to play an important role in the synaptic plasticity process following axotomy. There is also evidence that IFNγ may interfere in the differentiation and survival of neuronal cells. However, little is known about the effects of IFNγ absence on spinal cord neurons after injury. 相似文献63.
64.
CS Beardsmore 《Archives of disease in childhood》1995,73(6):519-523
The aim was to investigate pulmonary mechanics in patients with cystic fibrosis during infancy and again in early childhood to see whether infant tests predicted status at school age. Plethysmographic measurements of thoracic gas volume and airways resistance were made in 29 patients at 6 months and again at 5 years 10 months. Maximum flow at functional residual capacity was measured during infancy for comparison with maximum expiratory flow rates during childhood. While many patients had normal measurements during infancy, pulmonary function had deteriorated by school age. Thoracic gas volume at school age was significantly related to the values in infancy, but other measurements made during childhood were independent of infant values. The relations between measurements in infancy and early childhood described here provide a background against which the role of external factors on pulmonary function in young children with cystic fibrosis can be investigated. 相似文献
65.
Richard Reid MD Katherine H. Omoto MS Sheryl L. Precop RN NP Nancy R. Berman RN CS MSN Lisa H. Rutledge BA Steven M. Dean MD Mark Pleatment MD 《American journal of obstetrics and gynecology》1995,172(6):1684-1701
Objective: The management of chronic vulvovaginal pain, not explicable on specific histologic grounds, presents a major problem in referral centers for lower genital tract diseases.Study design: This article reports on a two-step protocol in a sample of 175 medical nonresponders, drawn from a 2-year cohort of 725 women with vulvovaginal pain. The first maneuver was the use of a flashlamp-excited dye laser to selectively photocoagulate symptomatic subepithelial blood vessels in 168 women; the second was the microsurgical removal of chronically painful Bartholin's glands in 52 women not responsive or not suited to flashlamp-excited dye laser photothermolysis.Results: Dye laser response rates werer independent of whether patients manifested macroscopic focl of painful erythema (“vestibular adenitis”) or just colposcopically apparent hyperemia-ectasia of the individual blood vessels (“pruritic papillomatosis”) (55% vs 45% after a single surgical procedure; 76% vs 65% after serial retreatment; p not significant). Conversely, response rates were much lower among women in whom pressure on the Bartholin's glands produced sharp, lancinating pain (15% vs 66% after a single surgical procedure; 22% vs 93% after serial retreatment; p < 0.001). Forty-two (85%) of 50 patients with flashlamp-excited dye laser failure had deep pain; however, the impasse to progress was broken by gland removal. Final response rates were 92.5% (complete response 62%; partial response 30%) in the “surface-only” group and 80.3% in the “surface-plus-deep” group (χ2 = 14.9; p < 0.001). The major complication was acute bacterial cellulitis, occurring in the first postoperative week. Modification of the treatment protocol to include topical antibiotics with an occlusive dressing reduced the cellulitis rate from 17.2% to 2.5%. In four women (1.8%) Koebner-like exophytic condylomas also developed within 1 month of flashlamp-excited dye laser surgery.Conclusion: The availability of a safe, efficacious, and relatively noninvasive treatment should reduce the need for resective surgery in most patients with idiopathic vulvodynia. 1995; 172; 1684–1701.) 相似文献
66.
背景和目的:罗格列酮与阿伐他汀联合疗法已经被证实对于2型糖尿病患者的血糖控制以及脂质水平都有益处。本试验将通过检测罗格列酮与阿伐他汀联合疗法对于2型糖尿病患者的生物标记水平的作用来研究该联合疗法对血管炎的作用。方法:30例患有2型糖尿病和高脂血症的患者被纳入治疗。对这些患者给予罗格列酮单一疗法4mg/d,持续3个月,然后在接下来的3个月中给予这些患者阿伐他汀10mg/d作为联合疗法。在研究开始时,罗格列酮单一疗法之后以及罗格列酮与阿伐他汀联合治疗之后测量炎性生物标记物,包括高敏C-反应蛋白(hs-CRP)、基质金属蛋白酶9(MMP… 相似文献
67.
68.
HU Jie胡杰 JIANG Cheng-chuan江澄川 Ho-Keung Ng吴浩强 Jesse CS Pang 彭颂先 Carol YK Tong唐婉君 CHEN Shang-qun 陈商群 《中国癌症研究》2002,14(3):183-186
Glioblastoma multiforme (GBM), the most malignant type of glioma, is the most common primary brainneoplasm. Although comprehensive therapeutic measures are applied, the prognosis of GBM remains dismal with a median post-treatment survival of less than one year.Modern molecular genetics has demonstrated thatabnormal alterations of tumor suppressor genes (TSGs) and oncogenes are the major mechanisms responsible for the initiation and progression of this malignant tumor.Identifying of related… 相似文献
69.
70.