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71.
Geographic prediction of tuberculosis clusters in Fukuoka,Japan, using the space-time scan statistic
Background
Tuberculosis (TB) has reemerged as a global public health epidemic in recent years. Although evaluating local disease clusters leads to effective prevention and control of TB, there are few, if any, spatiotemporal comparisons for epidemic diseases. 相似文献72.
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Akihito Fujimi Yusuke Kamihara Yuji Kanisawa Akari Hashimoto Chisa Nakajima Naotaka Hayasaka Naoki Uemura Toshinori Okuda Shinya Minami Satoshi Iyama Koichi Takada Tsutomu Sato Akinori Hara Yasunori Iwata Kengo Furuichi Takashi Wada Junji Kato 《International journal of hematology》2014,100(5):490-493
A 79-year-old female diagnosed with T cell/histiocyte-rich large B cell lymphoma in complete remission after six cycles of rituximab-combined chemotherapy developed severe anemia, reticulocytopenia, and bone marrow erythroid hypoplasia. She was diagnosed with pure red cell aplasia (PRCA) accompanied by Coombs-negative autoimmune hemolytic anemia evidenced by a lack of glycophorin-A-positive cells in the bone marrow, haptoglobin under the detection level, and a high titer of RBC-bound IgG. Anti-erythropoietin receptor (EPOR) antibody was detected in the serum, and oligoclonal α/β and γ/δ T cells were also detected in her peripheral blood by Southern blotting analysis. Parvovirus B19 DNA was not detected by PCR. Although the treatment with rituximab had limited efficacy (specifically, only for hemolysis), subsequent cyclosporine therapy led to prompt recovery of erythropoiesis with the disappearance of anti-EPOR antibody and oligoclonal T cells. This is the first case report of anti-EPOR antibody-associated PRCA in a patient with malignant lymphoma treated successfully with cyclosporine. 相似文献
75.
Ryo Nasu Yasuhito Nannya Akihito Shinohara Motoshi Ichikawa Mineo Kurokawa 《Annals of hematology》2014,93(7):1215-1223
Although calcineurin inhibitors (CNIs) with short-term methotrexate (stMTX) constitute standard prophylaxis for graft-versus-host diseases (GVHD) in hematopoietic stem cell transplantations (HSCT), comparative efficacy of cyclosporine A (CsA) and tacrolimus (Tac) still remains unclear. We have altered GVHD prophylaxis for standard-risk hematological malignancies from CsA (target trough level, 500 ng/mL) to Tac (15 ng/mL) both with stMTX in May 2008, enabling us to compare the efficacy of CNIs with little selection biases. The cumulative incidence of acute and chronic GVHD was comparable for CsA and Tac. Among the GVHD low-risk patients who received stem cells from matched sibling donors or cord blood, the Tac arm had a trend for favorable control of grade III–IV acute GVHD (6.7 vs. 30.0 %, p?=?0.2), which may contribute to the significantly better overall survival (p?=?0.048) and relapse-free survival (p?=?0.043) in that group. Inadequate concentration of CNIs in early phase of HSCT affected the cumulative incidence of acute GVHD in the CsA but not in the Tac arm. There were no differences in the GVHD incidence and survival outcomes between CsA and Tac in the GVHD high-risk subgroup. This study underlies the significance of maintaining adequate CsA concentration in standard-risk HSCT. 相似文献
76.
Kazunari Tominaga Mototsugu Kato Hiroshi Takeda Yasuyuki Shimoyama Eiji Umegaki Ryuichi Iwakiri Kenji Furuta Koichi Sakurai Takeo Odaka Hiroaki Kusunoki Akihito Nagahara Katsuhiko Iwakiri Takahisa Furuta Kazunari Murakami Hiroto Miwa Yoshikazu Kinoshita Ken Haruma Shin’ichi Takahashi Sumio Watanabe Kazuhide Higuchi Motoyasu Kusano Kazuma Fujimoto Tetsuo Arakawa G-PRIDE Study Group 《Journal of gastroenterology》2014,49(10):1392-1405
Background
The aim of this study was to investigate the efficacy of rikkunshito (RKT), a traditional Japanese medicine, combined with proton pump inhibitor (PPI) in patients with PPI-refractory non-erosive reflux disease (NERD).Methods
Patients with PPI-refractory NERD (n = 242) were randomly assigned to the RKT group [rabeprazole (10 mg/day) + RKT (7.5 g/t.i.d.) for 8 weeks] or the placebo group (rabeprazole + placebo). After the 4- and 8-week treatments, we assessed symptoms and quality of life (QOL) using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG), Gastrointestinal Symptom Rating Scale (GSRS), and Short-Form Health Survey-8 (SF-8).Results
There were no significant differences in FSSG and GSRS score improvement between these groups after the 4- and 8-week treatments. The mental component summary (MCS) scores of the SF-8 improved more in the RKT group (from 45.8 ± 8.1 to 48.5 ± 7.4) than in the placebo group (from 47.7 ± 7.1 to 48.4 ± 7.5) after the 4-week treatment (P < 0.05). The 8-week treatment with RKT was more effective for improvement of the degree of MCS score in patients with a low body mass index (<22) (P < 0.05) and significantly improved the acid-related dysmotility symptoms of FSSG in female and elderly patients (≥65 years).Conclusion
There were no significant differences in improvement of GERD symptoms in patients with PPI-refractory NERD between these groups. However, RKT may be useful for improving mental QOL in non-obese patients and acid-related dyspeptic symptoms, especially in women and the elderly. 相似文献77.
Noritomo Shimada Hidenori Toyoda Akihito Tsubota Tatsuya Ide Koichi Takaguchi Keizo Kato Masaki Kondoh Kazuhiro Matsuyama Takashi Kumada Michio Sata 《Journal of gastroenterology》2014,49(11):1485-1494
Background
Genetic polymorphisms near Interleukin 28B (IL28B) (rs8099917) and a rapid virological response (RVR) have been reported as predictors for a sustained virological response (SVR) to telaprevir (TVR)-based triple combination therapy. However, the association between SVR and viral kinetics earlier than week 4 after initiation of therapy remains unclear. Thus, we evaluated the SVR prediction ability of baseline factors and reduced hepatitis C virus (HCV) RNA levels at week 1 after the initiation of TVR-based therapy in Japanese genotype-1b chronic hepatitis C (CHC) patients.Methods
A total of 156 Japanese CHC patients received a 24-week regimen of TVR-based therapy. Baseline factors and reduction in HCV RNA levels at weeks 1 and 4 after the initiation of therapy were analyzed for SVR prediction.Results
Multiple logistic regression analysis for SVR in TVR-based therapy identified the IL28B TT genotype, a reduction of ≥4.7 log10IU/mL in HCV RNA levels at week 1, RVR, and treatment-naïve/relapse. Whereas the SVR rate was higher than 90 % regardless of the reduction in HCV RNA levels at week 1 in patients with the TT genotype, a reduction of ≥4.7 log10IU/mL in HCV RNA levels at week 1 was the strongest predictor of SVR in patients with the non-TT genotype, as determined by multiple logistic regression analysis (P = 0.0043).Conclusions
The IL28B TT genotype is the most important baseline factor for predicting SVR, and a ≥4.7 log10IU/mL reduction in HCV RNA at week 1 is a useful very early on-treatment predictor of SVR, especially in the non-TT genotype. 相似文献78.
Masanori Atsukawa Akihito Tsubota Hidenori Toyoda Koichi Takaguchi Makoto Nakamuta Tsunamasa Watanabe Kojiro Michitaka Tadashi Ikegami Akito Nozaki Haruki Uojima Shinya Fukunishi Takuya Genda Hiroshi Abe Naoki Hotta Kunihiko Tsuji Chikara Ogawa Yoshihiko Tachi Toshihide Shima Noritomo Shimada Chisa Kondo Takehiro Akahane Yoshio Aizawa Yasuhito Tanaka Takashi Kumada Katsuhiko Iwakiri 《Alimentary pharmacology & therapeutics》2019,49(9):1230-1241
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Akiomi INOUE Norito KAWAKAMI Teruichi SHIMOMITSU Akizumi TSUTSUMI Takashi HARATANI Toru YOSHIKAWA Akihito SHIMAZU Yuko ODAGIRI 《Industrial health》2014,52(6):535-540
This study was aimed to investigate the test-retest reliability and validity of a short
version of the New Brief Job Stress Questionnaire (New BJSQ) whose scales have one item
selected from a standard version. Based on the results from an anonymous web-based
questionnaire of occupational health staffs and personnel/labor staffs, we selected
higher-priority scales from the standard version. After selecting one item with highest
item-total correlation coefficient from each scale, a 23-item questionnaire was developed.
A nationally representative survey was administered to Japanese employees
(n=1,633) to examine test-retest reliability and
validity. Most scales (or items) showed modest but adequate levels of test-retest
reliability (r>0.50). Furthermore, job demands and job
resources scales (or items) were associated with mental and physical stress reactions
while job resources scales (or items) were also associated with positive outcomes. These
findings provided a piece of evidence that the short version of the New BJSQ is reliable
and valid. 相似文献