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991.
Yan KANG Qing-qing HONG Wei-ran CHAI Yong-lun FU Ai AI Qiu-ju CHEN Yan-ping KUANG 《生殖与避孕(英文版)》2013,24(1):10-20
Objective To compare the results of a novel regimen of human menopausal gonadotrophin (hMG) in combination with clomiphene citrate (CC) in mid-to-late follicular phase with those of a short protocol of GnRH agonist (GnRHa) and hMG used for IVF. Methods In the retrospective study, 842 patients undergoing IVF were collected and classified into two groups: hMG in combination with CC in mid-to-late follicular phase (group A, n=319) and short protocol of GnRHa-hMG (group B, n=523). The main outcome measures were ovarian responses in stimulation cycles and pregnancy outcomes in subsequent frozen-thawed embryo transfer (FET) cycles. Results In group A, the serum LH concentration on day 8-10 was similar with that on the day of hCG administration (2.43 ± 1.92 IU vs 2.51 ± 2.05 IU). The number of mature follicles and oocytes retrieved was significantly lower in group A than in group B while the fertilization rate and the cleavage rate were comparable. The clinical pregnancy rate (47.79% vs 48.04%), the implantation rate (32.49% vs 33.11%) and the cumulative pregnancy rate (58.09% vs 60.22%) were respectively similar in group A and group B. Conclusion hMG in combination with CC in mid-to-late follicular phase results in the same pregnancy outcome as short protocol. The novel protocol may take the advantage of eliminating the occurrence of a premature endogenous LH surge. 相似文献
992.
993.
目的研究中心静脉-动脉血二氧化碳分压差[P(cv-a)CO2]在指导感染性休克患者液体复苏的意义。方法选择2009年9月至2011年9月江西萍矿总医院中心ICU收治的感染性休克患者128例,入选68例。随机分组为A组(ScvO2组)30例,维持中心静脉压(CVP)8~12mm Hg(1mm Hg=0.133kPa),平均动脉压(MAP)65~90mm Hg,ScvO2≥70%,尿量大于或等于0.5mL.kg-1.h-1,治疗6h。B组[ScvO2+P(cv-a)CO2组]38例。维持CVP 8~12mm Hg,MAP 65~90mm Hg,ScvO2≥70%,尿量大于或等于0.5mL.kg-1.h-1,P(cv-a)CO2<6mm Hg,治疗6h。比较两组的疗效。结果两组患者在液体复苏6h后B组乳酸清除率、CI、ScvO2和CVP及液体平衡高于A组(P<0.05)。A组血管活性药物多巴酚丁胺及去甲肾上腺素用量较B组多(P<0.05)。结论 P(cv-a)CO2用于指导感染性休克患者液体复苏可以更好地评价有效循环血流量及组织灌注状态,也是作为判断感染性休克严重程度、治疗效果和预后的敏感指标。 相似文献
994.
目的 对收集的22批救必应药材进行性状、显微、HPLC指纹图谱鉴别。方法 以粉末显微特征为主,并采用HPLC法,色谱柱为Dikma C18(200 mm×4.6 mm,5 μm),以乙腈(A)-0.1%磷酸水溶液(B)为流动相,进行梯度洗脱,体积流量为1.0 mL/min;检测波长210 nm;柱温35 ℃。结果 性状、粉末鉴别评价所得出的药材质量优劣结果与指纹图谱相似度评价结果相一致,所建立的指纹图谱精密度、重复性、稳定性良好,可反映救必应药材的整体特征。结论 所建立的性状、粉末鉴别方法可以用于救必应药材及其混淆品的鉴别,HPLC指纹图谱可用于救必应药材的质量评价。 相似文献
995.
目的探讨婴幼儿支气管肺炎心电图P波振幅的特点,为心电图诊断提供科学依据。方法患有支气管肺炎的婴幼儿共143例,分为二组:其中轻症患儿组84例;重症患儿组59例。对照组为同时期门诊查体的正常同龄婴幼儿共96例。对支气管肺炎婴幼儿入院当日、一周PⅡ振幅及一周内心律失常发生率进行比较。结果入院当日PⅡ振幅重症组、轻症组分剐较正常组增高,重症组较轻症组增高(P〈0.01);入院1周各组间比较,PⅡ振幅重症组较正常组、轻症组增高(P〈0.01);二组支气管肺炎患儿入院1周内心律失常比较,重症组较轻症组室上性心律失常发生率增高,差异有统计学意义(P〈0.05)。结论婴幼儿支气管肺炎对心电图P波振幅有影响,与病情相关。 相似文献
996.
Bone morphogenetic protein-7 (BMP-7) has been shown to inhibit liver and renal fibrosis in in vivo and vitro studies. There is no study to investigate BMP-7's role in the development of pulmonary fibrosis induced by silica. In the current study, we used the rat model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in silica-induced pulmonary fibrosis. Sixty Wistar rats were randomly assigned into three groups. Control group received saline, silica group received silica and BMP-7 treated group received silica and BMP-7. BMP-7 was administered to silica-treated rats intraperitoneally at a dose of 300 μg/kg/injection from day 8 to day 30 every other day. After the animals were sacrificed on day 15 and 30, hydroxyproline levels, the protein expressions of BMP/Smad and TGF-β/Smad signaling, and histopathology in lung tissues were analyzed. The hydroxyproline contents in BMP-7 treated groups were significantly lower than the silica groups (P < 0.05). Histopathological results showed BMP-7 could reduce the progression of silica induced fibrosis. Furthermore, the expression of p-Smad1/5/8, a marker of BMP/Smad signaling, was significantly up-regulated in BMP-7 treated groups (P < 0.05) compared with the silica groups. On the contrary, the expression of p-Smad2/3, a marker for TGF-β/Smad signaling, reduced significantly in BMP-7-treated groups compared with silica groups (P < 0.05). In conclusion, the pulmonary fibrosis induced by silica in rats was significantly reduced with the therapeutic treatment of BMP-7. The antifibrotic effect of BMP-7 could be related to the activation of BMP/Smad signaling and inhibition of TGF-β/Smad pathways. 相似文献
997.
Shu-Ting Ren Yi-Ran Liao Xiao-Ning Kang Yi-Ping Li Hui Zhang Hong Ai Qiang Sun Jing Jing Xing-Hua Zhao Li-Fang Tan Xin-Liang Shen Bing Wang 《Pharmaceutical research》2013,30(6):1574-1585
Purpose
To develop a novel docetaxel (DOC)-loaded lipid microbubbles (MBs) for achieving target therapy and overcoming the poor water-solubility drawback of DOC.Methods
A novel DOC-loaded microbubble (DOC + MB) was prepared by lyophilization and the physicochemical properties including ultrasound contrast imaging of the liver were measured. The anti-tumor effect of the DOC + MBs combined with low-frequency ultrasound (LFUS; 0.8Hz, 2.56 W/cm2, 50% cycle duty) on the DLD-1 cancer cell line was examined using an MTT assay.Results
The physicochemical properties of the two tested formats of DOC + MBs (1.0 mg and 1.6 mg) was shown: concentration, (6.74?±?0.02)?×?108 bubbles/mL and (8.27?±?0.15)?×?108 bubbles/mL; mean size, 3.296?±?0.004 μm and 3.387?±?0.005 μm; pH value, 6.67?±?0.11 and 6.56?±?0.05; release rate, 3.41% and 12.50%; Zeta potential, ?37.95?±?7.84 mV and ?44.35?±?8.70 mV; and encapsulation efficiency, 54.9?±?6.21% and 46.3?±?5.69%, respectively. Compared with SonoVue, the DOC + MBs similarly enhanced the echo signal of the liver imaging. The anti-tumor effect of the DOC + MBs/LFUS group was significantly better than that of DOC alone and that of the normal MBs/LFUS groups.Conclusions
The self-made DOC + MBs have potential as a new ultrasound contrast agent and drug-loaded microbubble, and can obviously enhance the antitumor effect of DOC under LFUS exposure. 相似文献998.
目的 制备尼扎替丁氯化钠注射液,建立质量控制方法并考察其稳定性和安全性。方法 优化处方组成与制备工艺,并进行性状、鉴别、检查等质量研究,采用高效液相色谱法测定尼扎替丁含量,滴定法测定氯化钠含量,影响因素试验、加速试验和长期试验考察其稳定性,并进行生物安全性评价。结果 尼扎替丁在0.55~1.31mg·mL^-1与峰面积线性关系良好,其平均回收率为99.9%,RSD为0.44%。恒温加速试验6个月和长期留样试验12个月,其性状、pH值、溶液颜色、有关物质、不溶性微粒、无菌、内毒素、主药含量等均未见明显改变,安全性良好。结论 该制剂处方合理,制备工艺简便可行,质量可控,稳定性良好,用药安全。 相似文献
999.
Yue Dong Tong Zhao Wei Ai Waleed A. Zalloum Dongwei Kang 《Expert opinion on therapeutic patents》2013,23(11):871-879
ABSTRACTIntroduction: Human urate transporter 1 (URAT1), which is an influx transporter protein, is located at the apical surface of renal tubular cells and presumed to be the major transporter responsible for the reabsorption of urate from blood. About 90% of patients develop hyperuricemia due to insuf?cient urate excretion; thus, it is important to develop URAT1 inhibitors that could enhance renal urate excretion by blocking the reabsorption of urate anion.Areas covered: In this review, the authors addressed the patent applications (2016–2019) about URAT1 inhibitors and some medicinal chemistry strategies employed in these patents.Expert opinion: Substituent decorating, bioisosterism, and scaffold hopping are three common medicinal chemistry strategies used in the discovery of URAT1 inhibitors. Meanwhile, the introduction of sulfonyl group into small molecules has become one of the important strategies for structural optimization of URAT1 inhibitors. Furthermore, developing drug candidates targeting both URAT1 and xanthine oxidase (XOD) has attracted lots of interest and attention. 相似文献
1000.
目的: 探讨布地奈德联合肺力咳治疗小儿哮喘的临床效果. 方法: 对来本院诊治的80例患者入院资料进行分析,将其随机分为两组.对照组采用布地奈德混悬液治疗,实验组联合肺力咳治疗,比较两组治疗效果. 结果: 实验组95%治疗效果理想,高于对照组(80%)(P<0.05);实验组95%对本院治疗总体满意,高于对照组(P<0.05);实验组咳嗽缓解时间为(4.35±1.25) d,咳嗽消失时间为(8.99±2.17) d,平均治疗时间为(17.12±1.5) d,低于对照组(P<0.05);实验组治疗后一秒用力呼气容积(forced expiratory volume in one second, FEV1) 指标为(1.57±0.31) L、峰值呼气流速(PEF)为(3.82±0.37) L,FEV1/用力肺活量(FVC)指标为(83.54±0.62)%,高于对照组(P<0.05);实验组治疗后3例出现不良反应,不良反应率为7.5%,低于对照组22.5%(9/40)(P<0.05). 结论: 文章采用布地奈德联合肺力咳治疗效果理想,能够有效的改善患者症状,值得推广使用. 相似文献