全文获取类型
收费全文 | 388篇 |
免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
基础医学 | 34篇 |
口腔科学 | 64篇 |
临床医学 | 20篇 |
内科学 | 37篇 |
神经病学 | 11篇 |
特种医学 | 16篇 |
外科学 | 143篇 |
综合类 | 27篇 |
一般理论 | 1篇 |
预防医学 | 8篇 |
眼科学 | 5篇 |
药学 | 8篇 |
中国医学 | 4篇 |
肿瘤学 | 6篇 |
出版年
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 4篇 |
2018年 | 4篇 |
2015年 | 10篇 |
2014年 | 15篇 |
2013年 | 26篇 |
2012年 | 26篇 |
2011年 | 13篇 |
2010年 | 15篇 |
2009年 | 5篇 |
2008年 | 16篇 |
2007年 | 7篇 |
2006年 | 3篇 |
2005年 | 8篇 |
2004年 | 9篇 |
2003年 | 3篇 |
2002年 | 4篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1997年 | 10篇 |
1996年 | 5篇 |
1995年 | 8篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 12篇 |
1971年 | 8篇 |
1970年 | 11篇 |
1969年 | 4篇 |
1967年 | 4篇 |
1966年 | 3篇 |
1965年 | 3篇 |
1964年 | 3篇 |
排序方式: 共有394条查询结果,搜索用时 15 毫秒
81.
82.
Herrmann H 《Schmerz (Berlin, Germany)》1991,5(3):113-114
Ohne Zusammenfassung 相似文献
83.
Iyanda Ayodeji Emmanuel Chima-Adaralegbe Ngozi Adeleke Richard Lu Yongmei 《Zeitschrift fur Gesundheitswissenschaften》2022,30(6):1545-1555
Journal of Public Health - Suicide is one of the leading causes of death globally, inherently linked with mental health conditions. Existing studies have also found a significant association... 相似文献
84.
85.
JOB Olubodun FMCP MRCP OA Talabi MB BS 《International journal of clinical practice》1996,50(3):173-174
SUMMARY Although primary hepatocellular carcinoma (PHC) is quite common in adults in Africa, it is very rare in those under 25. The clinical diagnosis is usually straightforward by the time patients present and it is unusual to encounter differential diagnostic problems. We report an unusual clinical manifestation of PHC at the very young age of 15 years. The case presented clinically as a septicaemia-like illness that was initially thought to be typhoid. The patient died within 72h of presentation and the true diagnosis was only made at post-mortem. This case simultaneously highlights several problems commonly encountered in medicine in the developing world: late presentation, self-medication, and investigative and diagnostic difficulties related to inadequate facilities. 相似文献
86.
Ghali DW; Panzer S; Fischer S; Argyriou-Tirita A; Haas OA; Kovar H; Gadner H; Panzer-Grumayer ER 《Blood》1995,85(10):2795-2801
Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V delta 2-D delta 3, D delta 2-D delta 3) has not been reported, so far. We detected oligoclonality characterized by the coexistence of different junctional regions of identical V delta 2-D delta 3 rearrangements in four childhood precursor B-ALLs. No variation was found in the IgH gene status. Therefore, we define these populations as subclones. Two leukemias displayed the variants in an unequal proportion. In the other two leukemias, for which similar quantities of the coexisting rearrangements were detected, single cell-nuclei polymerase chain reaction (PCR) showed two separate leukemic populations. Subclone formation could not be demonstrated by Southern blot hybridization, but was detectable after PCR amplification of the V delta 2-D delta 3 rearrangement and separation by polyacrylamide gel electrophoresis. The variants arose independently from each other, as deduced from their individual sequences. Using subclone-specific oligonucleotides for hybridization to amplified DNA obtained at diagnosis and during follow- up from bone marrow samples, we demonstrate, (1) specificity of all subclone-deduced probes, (2) that one residual leukemic cell can be detected in 10(4) to 10(5) normal mononuclear cells in a semiquantitative assay, and (3) that none of the subclones persisted after induction therapy. We propose that in a leukemic cell population, TcR-delta gene diversity arises after rearrangements of the IgH genes resulting in apparent clonality at the IgH gene level. However, cells are oligoclonal, if the TcR-delta gene rearrangements are considered. As various subclones may respond differently to chemotherapy, they may hamper the detection of minimal residual disease. Therefore, we use all subclone-specific oligonucleotides for hybridization to amplified DNA from follow-up samples. 相似文献
87.
OA Mownah G Pafitanis WM Drake JN Crinnion 《Annals of the Royal College of Surgeons of England》2015,97(8):603-607
Introduction
Primary hyperparathyroidism (pHPT) is usually the result of a single adenoma that can often be accurately located preoperatively and excised by a focused operation. Intraoperative parathyroid hormone (IOPTH) measurement is used occasionally to detect additional abnormal glands. However, it remains controversial as to whether IOPTH monitoring is necessary. This study presents the results of a large series of focused parathyroidectomy without IOPTH measurement.Methods
Data from 2003 to 2014 were collected on 180 consecutive patients who underwent surgical treatment for pHPT by a single surgeon. Preoperative ultrasonography and sestamibi imaging was performed routinely, with computed tomography (CT) and/or selective venous sampling in selected cases. The preferred procedure for single gland disease was a focused lateral approach guided by on-table surgeon performed ultrasonography. Frozen section was used selectively and surgical cure was defined as normocalcaemia at the six-month follow-up appointment.Results
Focused surgery was undertaken in 146 patients (81%) and 97% of these cases had concordant results with two imaging modalities. In all cases, an abnormal gland was discovered at the predetermined site. Of the 146 patients, 132 underwent a focused lateral approach (11 of which were converted to a collar incision), 10 required a collar incision and 4 underwent a mini-sternotomy. At 6 months following surgery, 142 patients were normocalcaemic (97% primary cure rate). Three of the four treatment failures had subsequent surgery and are now biochemically cured. There were no complications or cases of persistent hypocalcaemia.Conclusions
This study provides further evidence that in the presence of concordant preoperative imaging, IOPTH measurement can be safely omitted when performing focused parathyroidectomy for most cases of pHPT. 相似文献88.
89.
Romana SP; Poirel H; Leconiat M; Flexor MA; Mauchauffe M; Jonveaux P; Macintyre EA; Berger R; Bernard OA 《Blood》1995,86(11):4263-4269
90.