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排序方式: 共有233条查询结果,搜索用时 31 毫秒
231.
Cemal ORHAN Füsun ERTEN Beir ER Mehmet TUZCU Nurhan AHN
znur Ece DURMAZ KURUN Vijaya JUTURU Kazim AHN 《Turkish Journal of Medical Sciences》2021,51(4):2167
Background/aim This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-κB/Nrf2 pathways, and synaptic plasticity proteins in trained rats.Materials and methods Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-κB levels decreased (p <0.001). Also, L/Zi improved BDNF, synapsin I, SYP, and GAP-43 levels of the cerebral cortex of trained rats (p < 0.001). The highest levels of BDNF, synapsin SYP, and GAP-43 in the cerebral cortex were determined in the Exercise+L/Zi group.Conclusion These results suggested that exercise combined with L/Zi supplementation might be effective to reduce neurodegeneration via improving neurotrophic factors and synaptic proteins, and oxidative capacity in the cerebral cortex. 相似文献
232.
Awad Mohamed M. Alhalabi Feras Bamuqadm Mohamed Alhoti Abdulmalik Almasaad Abdulilah Robiaan Ali Almahdy Ahmed Alrahlah Ali Ahmed Mohammed H. 《Odontology / the Society of the Nippon Dental University》2023,111(2):409-419
Odontology - The purpose of this study was to evaluate the effect of adhesive sonic agitation on resin–dentin micro-tensile bond strength (µTBS) and interfacial morphology at the... 相似文献
233.
Mohammed Aliyu Usman Abdulmalik Abdullahi Salman Mohammed Auwal Ibrahim Koji Furukawa Kazuhiko Yamasaki 《Chemical biology & drug design》2023,101(6):1241-1251
Malaria remains a threat to global public health and the available antimalarial drugs are undermined by side effects and parasite resistance, suggesting an emphasis on new potential targets. Among the novel targets, Plasmodium falciparum autophagy-related proteins (PfAtg) remain a priority. In this paper, we reviewed the existing knowledge on the functions and structural biology of PfAtg including the compounds with inhibitory activity toward P. falciparum Atg8-Atg3 protein–protein interaction (PfAtg8-PfAtg3 PPI). A total of five PfAtg (PfAtg5, PfAtg8, PfAtg12, PfAtg18, and Rab7) were observed to have autophagic and/or non-autophagic roles. Available data showed that PfAtg8 has conserved hydrophobic pockets, which allows it to interact with PfAtg3 to form PfAtg8-PfAtg3 PPI. Additionally, 2-bromo-N-(4-pyridin-2-yl-1,3-thiazol-2-yl) benzamide was identified as the most powerful inhibitor of PfAtg8-PfAtg3 PPI. Due to the dearth of knowledge in this field, we hope that the article would open an avenue to further research on the remaining PfAtg as possible drug candidates. 相似文献