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Jean-Yves Jenny Eug��ne Ciobanu Philippe Clavert Jean-Henri Jaeger Jean-Luc Kahn Jean-Fran?ois Kempf 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2011,21(6):391-396
We wanted to test the following hypothesis: the location of the tibial and femoral ACL attachments measured by a navigation
system differs from their actual anatomic location. A total of 10 gross specimens were studied. The standard navigated procedure
was used. Metallic reference pins were implanted around the tibial and femoral ACL attachments and palpated with a navigated
stylus. Their position was recorded in comparison with the same tibial or femoral reference point. All measurements were repeated
with a caliper. Caliper and navigated measurements were compared with appropriate statistical tests at a 0.05 level of significance.
There was a significant difference between caliper and navigated measurements at the tibia in absolute value (maximal range
of 4 mm, mean difference about 2 mm), but the difference ratio was low (about 3%); there was no significant difference between
caliper and navigated measurements at the femur. There was a strong correlation and a good agreement between caliper and navigated
measurements. It is likely that these differences have few, if any, clinical relevance. We demonstrated that the navigation
system used during the present study has the potential to enhance the precision of the intra-operative measurement of the
tunnel placement during ACL replacement. 相似文献
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Pia Kaiser Sebastian Maxeiner Alexander Weise Florain Nolden Anja Borck Thomas Forst Andreas Pf��tzner 《Journal of diabetes science and technology》2010,4(3):652-657
Reliable application of neutral protamine Hagedorn (NPH) insulin requires previous resuspension of the suspension by tipping over the cartridge 20 times. This procedure is considered annoying by patients. The goal of this investigation was to assess the efficiency of the mixing procedure when performed less frequently than recommended. Neutral protamine Hagedorn insulin cartridges from five different manufacturers (sanofi-aventis, Lilly, Berlin-Chemie, B. Braun, and Novo Nordisk) were emptied with doses of 28 IU in the morning and the evening over 5 days. While the first dose was obtained after a regular resuspension procedure (20× tipping over), the consecutive doses were obtained after 3, 6, 10, or 20 mixing procedures (12 cartridges per experimental series, two doses/day). Insulin concentrations of doses 1, 2, 6, and 10 were determined by high-pressure liquid chromatography. Between dosing, cartridges were stored at room temperature in a horizontal position. Comparable insulin concentrations were seen in the first correctly prepared doses. Pronounced and substantial deviations from the selected dose were observed with most of the cartridges, in particular when resuspending only 3 and 6 times. Mean absolute percentage deviations when tipping 3 times and maximally observed overdoses were: Insuman basal: 1.1 ± 1.0%/4 IU, Humulin N: 2.6 ± 3.4%/19 IU, Berlinsulin H basal: 4.4 ± 6.0%/26 IU, Insulin B. Braun basal: 10.4 ± 8.9%/38 IU, and Protaphane: 4.7 ± 4.1%/19 IU (all p < 0.05 vs Insuman basal). Only one cartridge with three metal mixing bullets (sanofi-aventis) was resuspended efficiently with only a few mixing procedures. All other cartridges with fewer bullets were shown to deliver potentially harmful doses if used for treatment when the mixing procedure was less frequent than demanded in the instructions for use. 相似文献
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Alberto Biondi Roberto Persiani Ferdinando Cananzi Marco Zoccali Vincenzo Vigorita Andrea Tufo Domenico D��Ugo 《World journal of gastroenterology : WJG》2010,16(27):3358-3370
Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor.In particular,lymphatic metastasis is one of the main predictors of tumor recurrence and survival,and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection.This is compounded by the observation that two-thirds of gastric cancer in the Western world... 相似文献