养寿丹对阿尔茨海默病肾阳虚模型大鼠学习记忆的影响

目的：寻求防治老年性痴呆的有效措施。方法：运用Morris水迷宫评价了古方养寿丹对由D－半乳糖致亚急性衰老，醋酸氢化可的松致肾阳虚合并Meynert核损毁所致阿尔茨海默病肾阳虚模型大鼠的学习记忆能力的保护作用。结果：养寿丹能够改善模型大鼠的学习记忆成绩，包括缩短模型大鼠在Morris水迷宫中寻找世平台的逃避潜伏期（P＜0．01），增加平台象限跨相应平台次数（P＜0．05）。结论：提示养寿丹对阿尔茨海默病肾阳模型大鼠的学习记忆能力有一定的保护作用。     

桂林市秀峰区2005～2007年性病发病情况分析

目的：了解桂林市秀峰区2005～2007年性病发病情况。方法：收集我院2005～2007年性病传染报告卡共计1330例。结果：3年性病报病共1330例,发病率呈逐年上升趋势。艾滋病、淋病、梅毒的平均发病率分别为37．45／10万、43．75／10万、283．16／10万,年平均发病率为121．45／10万。性病以梅毒为主,发病以农民和家务及待业人员为主,女性性病病例呈现逐年增多趋势。结论：性病防治形势仍十分严峻,应推广安全套使用和持续进行健康教育、咨询及行为干预策略和医疗干预策略结合起来,控制性病的传播、流行。     

养寿丹对阿尔茨海默病肾阳虚大鼠脑神经递质的影响

实验用D 半乳糖腹腔注射致亚急性衰老、醋酸氢化可的松肌肉注射致肾阳虚为基础 ,合并Meynert核损毁所致Alzhe imer型痴呆肾阳虚大鼠模型。通过Y 电迷宫进行大鼠行为测试 ,并检测脑神经递质。结果表明养寿丹能明显提高该模型大鼠的学习记忆能力 ,并能增加萎缩的肾上腺重量 ,提高血清皮质醇含量 ;对不同脑区降低的单胺类神经递质含量也有不同程度的提高 ,其中以海马、额叶去甲肾上腺毒 (NE)、5 羟色胺 (5 HT)更为明显 (P <0 0 1,P <0 0 0 1)。     

具抗HIV作用的天然逆转录酶抑制剂,蛋白酶抑制剂和整？…

综述目前开发的促进ＨＩＶ复制的逆转录酶抑制剂、ＨＩＶ蛋白酶抑制剂和ＨＩＶ整合酶抑制剂等３类抗ＡＩＤＳ药物的研究状况。     

中药学专业毕业生实习岗位技能培养探讨

在分析中药学专业实习岗位类型与特点的基础上,探讨毕业生实习岗位技能培养对提高实践教学质量、适应用人单位人才需求转变、化解实习与就业矛盾的意义,并从岗位与技能认知、非知识性技能因素影响、多岗主辅修实训制、岗前教育与培训、技能考核等方面思考岗位技能的培养与提高。     

手足口病2030例流行病学特征分析

目的 了解手足口病流行特征,为制订防治策略提供依据.方法 应用描述流行病学方法 对2 030例手足口病患者的发病资料进行分析.结果 2008～2011年共收治2 030例手足口病,2010年有一个发病高峰,其余年度的发病例数均接近;手足口病患者男性多于女性,男∶女=1.54 ∶1;0～5岁儿童占94.9%;常年均有发病,以夏季为发病高峰;高发人群以托幼儿童、散居儿童和学生为主,占98.9%;餐饮、食品业和教师也有少量病例,占0.3%.结论 应加大手足口病防控措施的指导与监督力度,重点预防0～5岁儿童,夏季高峰期更应加强防范.     

单向灌流法研究姜黄素的大鼠在体肠吸收

目的 研究姜黄素在大鼠肠内的吸收特性.方法 采用大鼠在体肠段单向灌流模型,HPLC法对药物的质量浓度进行检测,分别研究药物不同质量浓度、不同时间点以及吸收部位姜黄素吸收的情况.结果 姜黄素质量浓度对ka有显著性影响(P＜0.05),而对Kapp无显著性影响;姜黄素的肠吸收速率随时间出现周期性的波动,且在灌肠达到稳态后1h,ka的大小顺序为:40、20、80μg/ml;姜黄素在各肠段的ka和Kapp比较均无明显差异(P＞0.05),各肠段的ka(h-1)为十二指肠＞回肠＞空肠＞结肠;Kapp为十二指肠＞空肠＞回肠＞结肠.结论 姜黄索在吸收过程中存在高浓度饱和现象,初步判断姜黄素的吸收为主动转运.但姜黄素的浓度对其吸收的量影响不大;同时,姜黄素存在明显的肝肠循环;且在全肠道吸收较完全,无特定吸收窗也无明显吸收部位.     

桂林市1990～1993年儿童健康调查

桂林市１９９０～１９９３年儿童健康调查黄兆胜，陈智（桂林市妇幼保健院）关键词儿童；健康；调查；百分率ＳｕｒｖｅｙｏｎＣｈｉｌｄＨｅａｌｔｈｏｆＧｕｉｌｉｎＣｉｔｙｉｎ１９９０～１９９３￥／／定期进行儿童健康检查，是儿童保健工作的一项重要内容。为了掌握...     

中药功效认定及构成内涵探讨

中药功效让述不能与应用相混淆。中药功效认定时应充分考虑“方药离合”,针对临床辨证,辨病,辨证用药不同,认为中药功效包含“对证治本”功效、“对症治标”功效、“疗疾祛病”功效三个方面。     

Study on Diagnosis Criteria of Fire-Heat Syndrome Based on Receiver Operating Characteristic Curve and Principal Component Analysis

Objective: To establish the diagnostic quantitative criteria for fire-heat syndrome(FHS) of Chinese medicine(CM) based on the receiver operating characteristic(ROC) curve and principal component analysis(PCA). Methods: The symptoms and signs of FHS cases and healthy subjects from Guangzhou, Henan and Hunan of China were collected through questionnaire, and the diagnostic quantitative score tables were established for the three regions, respectively, with the method of maximum likelihood analysis. The homogeneity test was then performed on the diagnostic score tables for the three regions with ROC curve, and the diagnostic efficiency of diagnostic score tables for the three regions was compared with the prospective test and retrospective test. The method of PCA was adopted to obtain the analysis matrix for classifying the tapes of FHS. Results: Twenty-seven elements of FHS were confirmed through Chi-square test, and the diagnostic score tables for the three regions were established with the method of maximum likelihood analysis on the basis of the collected case data. According to the ROC curve test, the areas under ROC curve of Guangzhou diagnostic score table assessment with candidates in Guangzhou, Henan and Hunan were 0.998, 0.961 and 0.956, respectively. It showed that the diagnostic efficiency of Guangzhou diagnostic score tables was the highest one. With the prospective test, the area under ROC of Guangzhou diagnostic score table was 0.949, and more than any other diagnostic score table. By PCA, FHS was classified into excess fire and deficiency fire, and then classified into syndrome of flaring up of Heart(Xin) fire, syndrome of Lung(Fei)-Stomach(Wei) excess fire, syndrome of deficiency of Liver(Gan)-yin and Kidney(Shen)-yin, and syndrome of deficiency of Lung-yin from the view of viscera. In the retrospective test, the consistency with clinicians’ diagnosis was 69.4%, and in the prospective test, it was 70.1%. Conclusions: The Guangzhou diagnostic score table could be used as the recommended criteria for the diagnosis of FHS. The classification of FHS was basically in conformity with the clinical situation.