排序方式: 共有82条查询结果,搜索用时 15 毫秒
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从复方的研究,注射剂及单味药的研究3个方面对中医药治疗病毒性心肌炎的研究近况进行了综述.近年来从临床及实验方面均证实了中医药治疗病毒性心肌炎的满意疗效,显示出中医药治疗本病的优势. 相似文献
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苏木对大鼠同种异位心脏移植外周血IL-2、IL-6的影响及病理形态学观察 总被引:6,自引:0,他引:6
目的:观察苏木对同种异位心脏移植大鼠外周血细胞因子IL-2、IL-6水平的影响及病理形态学改变。方法:以Wistar大鼠为供体,以SD大鼠为受体,建立大鼠腹腔异位心脏移植模型,分为模型组、苏木组、CsA组,应用ELISA法检测外周血细胞因子IL-2、IL-6水平及病理观察。结果:苏木能明显降低大鼠外周血IL-2、IL-6的含量,改善病理形态学改变。结论:苏木水煎剂有明显的抗免疫排斥作用,可能是通过降低IL-2、IL-6的分泌而发挥的免疫抑制作用。 相似文献
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BACKGROUND: A large number of studies have shown that bone marrow mesenchymal stem cells (BMSCs) with differentiation ability can be used to treat kidney injury. Epimedium has good anti-inflammatory and immune restoration ability.
OBJECTIVE:To observe the effect of epimedium with BMSC transplantation on rat’s kidney disease caused by adriamycin nephrosis.
METHODS: Fifty rats were equivalently randomized to receive no treatment in control group, tail vein injection of normal saline plus intragastric injection of normal saline in model group, tail vein injection of BMSCs plus intragastric injection of epimedium decoction in combined group, tail vein injection of BMSCs in BMSCs group, and intragastric injection of epimedium decoction in epimedium group. Rat models of adriamycin nephrosis were made in the latter four groups through tail vein injection of doxorubicin hydrochloride, while rats in the control group were only given the same volume of normal saline. Twenty-four hours after modeling, rats in the latter four groups began to be given the corresponding treatments. Epimedium decoction was given in the combined and epimedium groups at a dose of 1 mL/d, for consecutive 1 week.
RESULTS AND CONCLUSION:Compared with the model group, mitigated kidney injury and reduced urinary protein level were found in rats undergoing BMSCs and/or epimedium decoction treatment; the levels of plasma albumin and catalase were significantly increased in the combined group and epimedium group, while the levels of serum cholesterol, triglycerides and malondialdehyde decreased; the mRNA expression of transforming growth factor β1 in the kidney tissues was dramatically declined in the combined group and BMSC group. To conclude, the combined use of epimedium and BMSCs is superior to their use alone in the treatment of kidney disease. 相似文献
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目的:观察苏木(Sappan Wood)对同种异位心脏移植大鼠心肌穿孔素(perforin,PFP)mRNA表达的影响。方法:以Wistar大鼠为供体,以SD大鼠为受体,建立腹腔异位心脏移植模型,以RT—PCR法检测苏木对穿孔素mRNA表达的影响。结果:苏木可明显降低穿孔素mRNA的表达,并能明显减轻病理形态学及心肌细胞超微结构的损伤。结论:苏木有明显的抗免疫排斥作用,可能是通过降低穿孔素mRNA的表达而发挥免疫抑制的作用。 相似文献
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益心胶囊对家兔急性心肌缺血模型血清及心肌组织NO和NOS的影响 总被引:4,自引:0,他引:4
目的 :探讨益心胶囊对心肌缺血家兔一氧化氮 (NO )及一氧化氮合酶 (NOS)的影响。方法 :雄性家兔 2 0只 ,随机分为 4组 ,每组 5只 ,预防给药 5d。灌胃结束后 ,开胸结扎家兔左冠状动脉前降支 ,建立心肌缺血动物模型 ,观察血清及心肌组织NO和NOS的变化。结果 :模型组、益心胶囊组、通心络组与假手术组比较 ,心肌组织NO及NOS含量均有明显降低(P <0 .0 5 ) ;而与模型组相比 ,益心胶囊组、通心络组的NO及NOS含量均有明显的恢复 (P <0 .0 5 ) ,提示益心胶囊能够提高心肌缺血家兔心肌组织NO及NOS含量。结论 :心肌缺血损伤时 ,血清及心肌组织NO及NOS含量明显降低 ,而益心胶囊能够显著提高心肌缺血家兔血清及心肌组织NO及NOS含量 ,对血管内皮细胞功能具有保护作用。 相似文献
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养心汤对家兔心肌缺血模型血清NO和NOS含量的影响 总被引:1,自引:0,他引:1
目的观察养心汤对家兔心肌缺血模型血清一氧化氮(NO)及其合酶(NOS)含量、心肌病理形态学改变,探讨其治疗不稳定型心绞痛的确切作用机制。方法将24只雄性家兔随机分为3组,每组8只,即正常组、模型组、治疗组。在高脂饮食形成动脉粥样硬化斑块基础上,复制成类似于人类的不稳定型心绞痛病理变化的家兔心肌缺血模型。治疗组予养心汤灌胃,4g/kg每日1次。连续2周观察NO、NOS含量。结果正常组兔NO、NOS含量8周与10周时无明显改变高脂喂养8周后模型组与治疗组NO、NOS分别(37.05±1.99)μmol/L,(10.20±0.97)U/mL,均优于模型组(P<0.01)。结论养心汤通过调整血管内皮功能,提高NO、NOS的产生,从而保护缺血心肌,这可能是其治疗不稳定型心绞痛的作用机制之一。 相似文献
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