Relation of serum uric acid and cardiovascular plaque composition by intravascular ultrasound

Background To investigate the relationship btween serum uric acid （SUA） and cardiovascular plaque composition by intravascular ultrasound （IVUS）. Methods From March 2005 to August 2009, 81 patients were explored cardiovascular plaque composition by IVUS and taken SUA of measurement. According to American Heart Association IVUS criterion, coronary artery plaque was divided into four categories： （1） Fibrous plaque; （2） Soft plaque; （3） Calcified plaque; （4） Mixed plaque. We investigated the relationship btween SUA and cardiovascular plaque composition by IVUS. Results It was shown that the level of SUA in calcified plaque group was significantly higher than other three groups（P0.01）, which in fiber plaque group was significantly higher than mixed plaque group（P=0.032）, there was no significant difference between soft plaque group and mixed plaque group（P=1.00）among the four groups. The level of SUA among the four groups from high to low was as follows：calcified plaque, fibrous plaque group, soft plaque group and mixed plaque group. Conclusions The present study found that higher SUA in calcified plaque group, which proved that the relationship between SUA and cardiovascular plaque composition.     

血管缝合器的临床应用

目的：评价血管缝合器Perclose在冠脉介入治疗术（PCI）后止血的可靠性、安全性及临床应用价值。方法：120例经股动脉冠脉介入治疗术后，应用Perclose缝合器缝合止血，记录止血时间、下肢制动时间及血管并发症。结果：应用Perclose缝合止血成功率97．5％（95／120）。止血时间2．02？．1min，制动时间4．4？．8h。1例发生血肿。结论：在PCI术后应用血管缝合器Perclose缝合止血是可靠的、安全的，可明显缩短止血时间及下肢制动时间，并有助减少血管穿刺部位血肿等并发症的发生率。     

冠脉介入治疗术后Perclose血管缝合止血的应用

目的　评价在冠脉介入治疗术 (PCI)后应用血管缝合装置Perclose止血的可靠性、安全性及临床应用价值。方法　 98例经股动脉冠脉介入治疗术后 ,应用Perclose装置缝合血管止血 ,记录止血时间、下肢制动时间及血管并发症。结果　应用Perclose血管缝合成功率 97% (95 / 98)。止血时间 2 0 1min± 1 2min ,制动时间 4 5h± 1 9h。 1例发生血肿。结论　血管缝合装置Perclose是一种安全、可靠的止血方法 ,术后的止血时间及患肢制动时间明显缩短 ,并有助减少血管穿刺部位血肿等并发症的发生率     

应用模糊聚类分析方法评价^99mTc—MIBI心肌断为像中心肌的 …

目的探讨模糊聚类分析的方法应用于核素心肌断层显像。方法对１２６例＾９９ｍＴｃ－ＭＩＢＩ心肌断层显像异常的病人,并且在一个月内行过冠状动脉造影的病人进行回顾性的分析,建立＾９９ｍＴｃ－ＭＩＢＩ心肌断层显像的各因素变量集,设立各因素变量的隶属度,权重及心肌缺血的诊断原型,将心肌缺血严重程度分为轻、中、重。计算出每个病人的各因素变量的模糊集合与心肌缺血严重程度原型的贴近度,确定其试验的心肌缺血的异常程度     

西罗莫司涂层支架与非涂层支架治疗急性心肌梗死的疗效及安全性比较

1 文献类型 治疗。 2 证据水平 1a。     

Study of the Correlation between Plasma Homocysteine and Coronary Artery Disease

Objectives This paper isto investigate the correlation between plasma total ho-mocysteine (tHcy) and coronary artery disease(CAD).Methods Using high performance liquid chromato-graph to determine the level of plasma tHcy in 215cases, and they were selective coronare angiography.107 cases were determined to have CAD with at leastone vessel was narrowed <50%. 108 cases were non-narrowed, and they were listed as controls. Their 10parameters such as sex, age, body height, body weightand blood lipid etc. were no statistical difference be-tween two groups. Results The plasma tHcy 11.20(±5.56) μmol/L of the CAD group and 11.46(±5.50) ofthe control group, between them there was no statisti-cal difference (P>0.5). 12.17 (±6.25)μmol/L tHcyconcentration of the male was significant higher than9.60(±5.10) of the female (P<0.001). ConclusionsNone of correlation between the plasma tHcy andCAD can be found, and the tHcy of male is higherthan that of female.     

辛伐他汀对动脉粥样硬化斑块中MMPs及TIMPs表达的影响

目的 :观察辛伐他汀对动脉粥样硬化斑块中基质金属蛋白酶 （MMPs）及其组织抑制因子 （TIMPs）表达的影响。方法 :新西兰大白兔 48只随机分为试药组和对照组 ,用 PTCA球囊导管拉伤腹主动脉 ,高脂饮食喂养 4周后 ,试药组 （2 4只 ）给予辛伐他汀 5m g· kg- 1· d- 1,对照组 （2 4只 ）以淀粉为对照 ;每组按实验终点 （给药后 2、4和 8周 ）随机分为 3个亚组 ,继续高脂饮食喂养至实验结束。动物高脂喂养前、每周和处死前取静脉血 2 ml检测血脂变化 ,取拉伤段动脉用于总 RNA提取和组织病理检测。结果 :高脂饮食喂养 1周后 ,2组动物血脂水平在正常的 5～10倍 ,组间无显著差异 （P>0 .0 5） ;用药后 2周 ,试药组血脂明显低于对照组 ;用药后 4周 ,试药组血管组织MMP1,2低于对照组 ,TIMP1/ MMP1明显大于对照组 （P <0 .0 5,P<0 .0 1） ,TIMPs表达两组无显著差异 （P >0 .0 5）。结论 :辛伐他汀通过选择性地改变局部 MMPs和 TIMPs表达 ,减少基质分解破坏 ,增加局部斑块的稳定性     

紧急PTCA术治疗左总干严重狭窄合并心跳骤停1例

紧急ＰＴＣＡ术治疗左总干严重狭窄合并心跳骤停１例周颖玲，靳立军，李瑜辉，孙家珍患者，女性，３５岁．反复发作胸前区压榨样不适３个月，伴晕厥４次入院。患者２个月前因胸前区压榨样不适症状，在我院行冠状动脉和左心室造影术，结果提示左总干开口偏心狭窄６０～７０...     

冠状动脉造影和介入治疗术后Perclose血管缝合与常规压迫止血的对比研究

近年来几种血管缝合止血方法在国外临床上试用 ,并取得一定的临床效果[1 7] 。Ｐｅｒｃｌｏｓｅ (美国ＡＢＯＴＴ公司生产 )是最近研制并应用到临床上的一种血管缝合装置[5] 。本研究通过与常规压迫止血方法比较 ,评价Ｐｅｒｃｌｏｓｅ血管缝合止血 (简称缝合止血 )方法的安全性和有效性。对象与方法　　 1 病例与分组 :全部病例为 2 0 0 0年 12月 1日～ 2 0 0 1年 5月 1日所做的冠状动脉造影或介入治疗病例共 2 2 0例。其中单纯冠状动脉造影 80例 ,冠状动脉介入治疗 14 0例 ,依止血方法不同分为压迫止血组 (10 0例 )和血管缝合组 (12 0例 )…     

冠心病冠状动脉支架置入术住院死亡33例分析

目的探讨分析冠状动脉支架置入术治疗中住院死亡病因。方法1994-012004-03对广东省人民医院的3252例冠心病病人,行冠状动脉支架置入术治疗术中及术后33例住院死亡患者作回顾性分析。结果其中4例死于术中,其余29例患者死于术后,主要死亡原因依次为:心源性休克、室颤、急性左心衰、多器官衰竭、心脏破裂、急性肾衰,住院病死率为1·01%。结论冠心病冠状动脉支架置入术死亡主要原因是心源性休克、室颤、急性左心衰等。通过一些措施,可以进一步降低住院患者病死率。