瘀血证与活血化瘀治法

最近几年,各地应用活血化瘀方药治疗各科有瘀血表现的病证相当广泛,取得了一定效果。实践证明,活血化瘀确是一种古老而又富有生命力的治疗法则和治疗方法。当前,应用活血化瘀治法有两种值得注意的倾向。一种是临证处方,动笔就来,似乎活血化瘀可以“通治百病”;另一种是一听就摇头,怕用活血化瘀方药治病。其实,用中医辨证施治的理论来认识活血化瘀治法,就会一分为二,应用得当,而不至陷于盲目性或片面性。     

新世纪心血管病学的展望

20世纪在心血管病学方面的科学成就是十分激动人心的。1903年，心电图描计器的发明，是心血管系统疾病诊断方面的里程碑，不仅提高了对心脏疾病尤其是心律失常的诊断水平，也促进了心电生理学的研究和新药的开发。现在，由于进一步发展了核素心肌扫描术、号称“真正的听诊器”的超声诊断术、核磁共振成像术、心脏血管造影术、超速CT扫描术和PET扫描术等，使心血管     

实施临床试验报告规范,提高临床试验透明度

临床试验是指以人为对象的前瞻性研究,预先将受试者或受试人群分配至接受一种或多种医疗干预,以评价医疗干预对健康结局的影响。其中"医     

中西医结合科学研究和开发

中国传统医药学是中华民族的科学宝库之一。我们这一代人有幸得以运用现代化科学知识和方法加以继承、整理与提高,开展中西医结合的科学研究,不胜欣慰。45年来,中西医药工作者孜孜不倦,勤奋工作,开通了航道,取得了辉煌的成就。展望即将到来的新世纪,我们当继续开拓,摆脱各种困境或困惑,做出更大更好的贡献。     

益气养阴与解毒活血中药对心肌梗死后大鼠早期心室重构心肌NF-κB和PPAR-γ mRNA表达的影响

目的 研究益气养阴活血与解毒活血中药对心肌梗死后大鼠早期心室重构的影响及作用机制.方法 结扎Wistar雄性大鼠冠状动脉左前降支,造成急性心肌梗死(AMI)模型,随机分为假手术组(只穿刺,不结扎)、模型组、培哚普利组、益气养阴活血组、解毒活血组(每组10只),分别灌胃,另设正常组10只给予等量水.4周后麻醉处死大鼠,检测左室重量指数(LVMI),测定动物血清高敏C-反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)等炎症因子含量,利用反转录聚合酶链式扩增(RT-PCR)方法检测大鼠缺血心肌核因子κB(NF-κB) mRNA和过氧化物酶增殖体激活受体-γ(PPAR-γ) mRNA的表达水平.结果 与模型组比较,培哚普利组、益气养阴活血组、解毒活血组大鼠的左心室重量和LVMI均不同程度降低(P<0.01,P<0.05).解毒活血组能明显降低血清IL-6(P<0.05);益气养阴活血组和解毒活血组均能使心肌组织的PPAR-γ和NF-κBp65 mRNA的表达明显降低(P<0.05),解毒活血中药对PPAR-γ mRNA降低作用大于益气养阴活血中药(P<0.05).结论 益气养阴活血与解毒活血中药组分通过不同途径减轻大鼠AMI后组织炎症基因的表达,从而抑制大鼠AMI后的心室重构.     

Herb-drug interaction: An emerging issue of integrative medicine

With the increasing enhancement of people＇s awareness of self-care,the voice for humans to return to nature is growing louder and louder.Drugs with natural plants as raw materials are increasingly favored by people all over the world for their unique advantages in preventing and curing diseases, rehabilitation and health care,especially in Europe,     

人参三七组方对人脐静脉内皮细胞血管内皮生长因子分泌及其受体2表达的影响

目的：探讨益气活血中药人参三七组方对人脐静脉内皮细胞（human umbilical vein endothelial cell,HUVEC）血管内皮生长因子（vascular endothelial growth factor,VEGF）及其受体2（vascular endothelialgrowth factor receptor-2,VEGFR-2）表达的影响。方法：体外培养HUVEC,分为高剂量人参三七组方（0.4 mg/mL）组、中剂量人参三七组方（0.2 mg/mL）组、低剂量人参三七组方（0.1 mg/mL）组,另设碱性成纤维细胞生长因子（bovine basic fibroblast growth factor,bFGF,320 U/mL）阳性对照组和只加培养液的空白对照组。酶联免疫吸附测定法检测细胞上清液中的VEGF含量,免疫细胞化学法检测VEGFR-2阳性细胞数及其光密度值,蛋白印迹法检测VEGFR-2蛋白的表达。结果：与空白对照组比较,高剂量人参三七组方组和bFGF组细胞上清液中VEGF含量增加（P〈0.05）,VEGFR-2阳性细胞数及光密度值增加,细胞中VEGFR-2蛋白表达增强。结论：促进HUVEC分泌VEGF和表达VEGFR-2可能是人参三七组方促血管生成的基础。     

Complementary and Alternative Medicine:Is It Possible to Be Mainstream?

<正>Complementary and alternative medicine(CAM), also known as non-conventional medicine,is used to refer to a broad set of health care practices(such as he rbal medicine,acuPuncture,yoga,Taichi, Qigong,meditation,manual therapies,homeopathic medicine,etc.)that are not part of a country's own tradition,or not integ rated into its dominant health care system.In fact,CAM iS generally used in most developed countries,especially in North America,     

Convergence: The tradition and the modern

Recently,Nature(Vol.480 No.7378_supp ppS81-S121,2011) published a special edition of traditional Asian medicine.The title is derived from traditional Chinese medicine.The topics that this special edition discussed are very comprehensive, embedding the development of traditional medicine tracing from its origin to today’s debate on its modernization,including ways to evaluate its safety, efficacy and its legislation.Some perspectives in the     

Bridging the traditional chinese medicine pattern classification and biomedical disease diagnosis with systems biology

<正>Being the unique core of traditional Chinese medicine(TCM),pattern classification exerts a direct effect on the efficacy and safety of herbal interventions.In this article,the authors integrated the pattern classification and disease diagnosis with many approaches from systems biology.Integration of pattern classification with biomedical diagnosis by systems biology is not only a new direction of personalized medicine development,but also provides a new drug development model.In the further study,the pattern classifications of major diseases will be the focus of research.