全文获取类型
收费全文 | 4653篇 |
免费 | 6435篇 |
国内免费 | 431篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 73篇 |
妇产科学 | 38篇 |
基础医学 | 198篇 |
口腔科学 | 20篇 |
临床医学 | 857篇 |
内科学 | 522篇 |
皮肤病学 | 33篇 |
神经病学 | 138篇 |
特种医学 | 78篇 |
外科学 | 405篇 |
综合类 | 1412篇 |
一般理论 | 1篇 |
预防医学 | 3284篇 |
眼科学 | 292篇 |
药学 | 641篇 |
3篇 | |
中国医学 | 868篇 |
肿瘤学 | 2640篇 |
出版年
2024年 | 20篇 |
2023年 | 628篇 |
2022年 | 1638篇 |
2021年 | 1061篇 |
2020年 | 1203篇 |
2019年 | 757篇 |
2018年 | 654篇 |
2017年 | 129篇 |
2016年 | 738篇 |
2015年 | 962篇 |
2014年 | 158篇 |
2013年 | 149篇 |
2012年 | 285篇 |
2011年 | 278篇 |
2010年 | 322篇 |
2009年 | 153篇 |
2008年 | 207篇 |
2007年 | 216篇 |
2006年 | 146篇 |
2005年 | 170篇 |
2004年 | 157篇 |
2003年 | 148篇 |
2002年 | 122篇 |
2001年 | 157篇 |
2000年 | 487篇 |
1999年 | 262篇 |
1998年 | 83篇 |
1997年 | 39篇 |
1996年 | 51篇 |
1995年 | 47篇 |
1994年 | 31篇 |
1993年 | 48篇 |
1992年 | 7篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1979年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 10 毫秒
21.
目的 探讨miR-218-5p与HMGB1在HSP、HSPN患儿外周血的表达及临床意义。方法 选择过敏性紫癜(Henoch-Schnlein purpura, HSP)、紫癜性肾炎(Henoch-Schnlein purpura nephritis, HSPN)住院患儿各30例作为实验组,门诊体检儿童30例作为对照组。采用RT-PCR技术检测外周血中miR-218-5p的表达,ELISA法检测外周血中HMGB1的表达,观察3组儿童中miR-218-5p、高迁移率族蛋白1(high-mobility group box-1, HMGB1)的表达水平,同时分析HSP组、HSPN组两组间白细胞计数(white blood cell, WBC)、中性粒细胞绝对计数(absolute neutrophil count, ANC)、淋巴细胞绝对计数(absolute lymphocyte count, ALC)、红细胞计数(red blood cell, RBC)、血小板计数(platelet, PLT)、尿素(urea, UREA)、肌酐(creatinine, CRE)、尿酸(uric acid, UA)的表达。结果 miR-218-5p表达在对照组、HSP组、HSPN组逐渐降低; HMGB1表达在对照组、HSP组、HSPN组逐渐增高; miR-218-5p、HMGB1、WBC、ANC与肾脏损伤发生差异有统计学意义;而ALC、RBC、UREA、CRE、UA与肾脏损伤发生差异无统计学意义;miR-218-5p是HSP患儿发生肾脏损伤的独立保护性因素,HMGB1是独立危险性因素;miR-218-5p在HSP发展过程中诊断肾脏损伤的最佳截断值为0.515,敏感度为100.0%,特异性为76.7%;HMGB1诊断肾脏损伤的最佳截断值为3348.2pg/ml,敏感度为86.7%,特异性为90.0%。结论 miR-218-5p可能通过靶向调节HMGB1的表达参与HSP、HSPN的发病机制,并且与病情严重程度相关,有望成为HSP患儿的生物学靶点。 相似文献
22.
23.
24.
Zola H Swart B Boumsell L Mason DY;IUIS/WHO Subcommittee 《Journal of immunological methods》2003,275(1-2):1-8
The 7th International Workshop on Human Leucocyte Differentiation Antigens (HLDA7) studied a number of newly characterised molecules relevant to human leucocyte differentiation and function. The HLDA organisation, which devised and continues to maintain the CD nomenclature, is responsible, under the auspices of IUIS and WHO, for the nomenclature of all leucocyte differentiation markers. The 7th Workshop redefined a number of (principally carbohydrate) molecules, and assigned CD names to approximately 80 new molecules. This update lists, in tabular form, the redefined and newly assigned names, together with antibodies, which have been confirmed under Workshop conditions as specific for the new and redefined molecules. The major features of the cellular expression patterns are summarised, and a LocusLink accession number provided to enable the reader to access more detailed information through http://www.ncbi.nlm.nih.gov/LocusLink. 相似文献
25.
Ekouevi DK Rouet F Becquet R Inwoley A Viho I Tonwe-Gold B Bequet L Dabis F Leroy V;ANRS / Ditrame Plus Study Group 《Journal of acquired immune deficiency syndromes (1999)》2004,36(2):755-757
The aim of this study performed in Abidjan, C?te d'Ivoire, was to describe the distribution of CD4+ T-cell lymphocytes (CD4) in HIV-1-infected (HIV+) pregnant women diagnosed during prenatal voluntary counseling and testing and to assess whether HIV-related immunodeficiency influenced the acceptance of an antiretroviral (ARV) package (zidovudine beginning at 36 weeks of amenorrhea plus intrapartum nevirapine) to prevent mother-to-child transmission. Between April and June 2002, a CD4 count was systematically performed in all HIV+ women (n=221) in 5 antenatal clinics carrying out voluntary counseling and testing. No difference in CD4 count was found in HIV+ women who did not return for their test result (n=50) and those who were informed of their positive serostatus (n=171) (median CD4 count: 389/mm3 vs. 420/mm3; P=0.19). We also found a lack of difference in CD4 count in those who accepted ARV (n=72) and those who did not but knew their HIV status (n=99) (median CD4 count: 405/mm3 vs. 425/mm3; P=0.47). The overall uptake of the intervention (31.9%) appeared to be independent of the maternal immune status. 相似文献
26.
27.
28.
Herbst JH Sherba RT Crepaz N Deluca JB Zohrabyan L Stall RD Lyles CM;HIV/AIDS Prevention Research Synthesis Team 《Journal of acquired immune deficiency syndromes (1999)》2005,39(2):228-241
This meta-analysis examines the efficacy of international HIV prevention interventions designed to reduce sexual risk behavior of men who have sex with men (MSM). We performed a comprehensive search of published and unpublished English-language reports of HIV prevention interventions that focus on MSM and evaluated changes in risky sexual behavior or biologic outcomes related to sexual risk. Data from 33 studies described in 65 reports were available as of July 2003. Studies with insufficient data to calculate effect sizes were excluded from the meta-analysis. Interventions were associated with a significant decrease in unprotected anal intercourse (odds ratio [OR] = 0.77, 95% confidence interval [CI]: 0.65-0.92) and number of sexual partners (OR = 0.85, 95% CI: 0.61-0.94) and with a significant increase in condom use during anal intercourse (OR = 1.61, 95% CI: 1.16-2.22). Interventions successful in reducing risky sexual behavior were based on theoretic models, included interpersonal skills training, incorporated several delivery methods, and were delivered over multiple sessions spanning a minimum of 3 weeks. Behavioral interventions provide an efficacious means of HIV prevention for MSM. To the extent that proven HIV prevention interventions for MSM can be successfully replicated in community settings and adapted and tailored to different situations, the effectiveness of current HIV prevention efforts can be increased. 相似文献
29.
目的 了解江西省居民伤害死亡流行情况及其疾病负担,为科学制定本省伤害防制策略和措施提供依据。方法 利用中国死因登记报告信息系统2014—2019年江西死因监测数据,应用Excel 2007和SPSS 17.0软件进行数据整理和分析。采用死亡数、粗死亡率、标化死亡率、构成比、潜在减寿年数(PYLL)、减寿率(PYLLR)和平均潜在减寿年数(AYLL)等指标进行统计学描述,趋势变化采用年度变化百分比(APC)进行分析。结果 2014—2019年江西报告伤害死亡25 638人,年均粗死亡率为 50.81/10万,年均标化死亡率为 49.55/10万。男性死亡率高于女性、城市死亡率高于农村。伤害死亡前5位死因分别为道路交通事故、跌落、溺水、自杀和中毒。溺水、交通事故、跌落分别是0~14岁、15~44和45~64岁、≥65岁的首位伤害死因。2014—2019年江西省前5位伤害死因中,跌落粗死亡率呈上升趋势(APC = 8.22%),中毒粗死亡率均呈下降趋势。2014—2019年伤害PYLL为692 196.73人年,PYLLR为14.24‰,AYLL 为 33.77年。PYLL及PYLLR 交通事故最高,AYLL最高的为溺水。15~44岁年龄组PYLL最高。结论 江西省伤害死亡负担较重,应根据不同人群的伤害死亡特征制定相应的防控策略和措施。 相似文献
30.
目的 探讨缺血性卒中相关性肺炎的危险因素。方法 回顾性纳入2018年1月—2020年12月期间唐山市协和医院神经内科住院的急性缺血性卒中(acute ischemic stroke, AIS)患者,收集人口统计学及临床资料。根据是否发生卒中相关性肺炎(stroke - associated pneumonia, SAP)分为非SAP组和SAP组,比较两组的各项临床资料,并采用多因素logistic回归分析SAP的独立影响因素。结果 共纳入721例患者,平均年龄(65.63±12.07)岁;SAP组年龄、入院美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评分,冠心病、心房颤动、卒中史、吞咽障碍和入院格拉斯哥昏迷评分≤10分的比例、同型半胱氨酸、纤维蛋白原和白细胞计数均高于非SAP组,而SAP组入院舒张压、高密度脂蛋白胆固醇、白蛋白、白蛋白与球蛋白比值、血红蛋白和红细胞计数均低于非SAP组,差异均有统计学意义;多因素logistic回归分析显示,年龄增高(OR = 1.055,95%CI:1.009~1.103)、入院NIHSS评分增加(OR = 1.290,95%CI:1.154~1.444)、白细胞计数升高(OR = 1.267,95%CI:1.101~1.457)是SAP发生的危险因素。结论 缺血性卒中相关性肺炎与高龄、入院NIHSS评分增加和白细胞计数升高相关。 相似文献