全文获取类型
收费全文 | 3771篇 |
免费 | 7120篇 |
国内免费 | 355篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 32篇 |
妇产科学 | 28篇 |
基础医学 | 1282篇 |
口腔科学 | 39篇 |
临床医学 | 739篇 |
内科学 | 569篇 |
皮肤病学 | 21篇 |
神经病学 | 114篇 |
特种医学 | 59篇 |
外科学 | 332篇 |
综合类 | 1114篇 |
预防医学 | 3173篇 |
眼科学 | 74篇 |
药学 | 280篇 |
中国医学 | 787篇 |
肿瘤学 | 2575篇 |
出版年
2024年 | 6篇 |
2023年 | 633篇 |
2022年 | 1230篇 |
2021年 | 1095篇 |
2020年 | 1272篇 |
2019年 | 1140篇 |
2018年 | 913篇 |
2017年 | 70篇 |
2016年 | 708篇 |
2015年 | 914篇 |
2014年 | 112篇 |
2013年 | 83篇 |
2012年 | 201篇 |
2011年 | 257篇 |
2010年 | 91篇 |
2009年 | 56篇 |
2008年 | 191篇 |
2007年 | 362篇 |
2006年 | 162篇 |
2005年 | 172篇 |
2004年 | 172篇 |
2003年 | 157篇 |
2002年 | 108篇 |
2001年 | 322篇 |
2000年 | 361篇 |
1999年 | 182篇 |
1998年 | 116篇 |
1997年 | 58篇 |
1996年 | 23篇 |
1995年 | 13篇 |
1994年 | 32篇 |
1993年 | 11篇 |
1992年 | 1篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
961.
962.
963.
Launay O Grabar S Gordien E Desaint C Jegou D Abad S Girard PM Bélarbi L Guérin C Dimet J Williams V Krivine A Salmon D Lortholary O Rey D;HEPAVAC Study Group 《Journal of acquired immune deficiency syndromes (1999)》2008,49(3):272-275
BACKGROUND: The immunogenicity of vaccines, including vaccine against hepatitis A virus (HAV), is impaired in patients with HIV infection, requiring revised immunization regimens. METHODS: We evaluated the immunological efficacy and safety of a 3-dose schedule of hepatitis A vaccine in HIV-infected adults. HAV-seronegative HIV-infected adults were randomized to receive either 3 doses of 1440 UI of hepatitis A vaccine (HAVRIX; GlaxoSmithKline, Marly le Roi, France) at weeks 0, 4, and 24 (46 patients) or 2 doses 24 weeks apart (49 patients). RESULTS: At week 28, seroconversion, defined as an anti-HAV antibody >or=20 mIU/mL, occurred in 82.6% and 69.4% of patients in the 3-dose and the 2-dose group, respectively (P = 0.13, intent-to-treat analysis, missing data = nonresponder), and in 88.4% and 72.3% of patients in the 3-dose and the 2-dose group, respectively (P = 0.06, observed analysis). Only 37.9% of patients experienced seroconversion after 1 vaccine dose (intent-to-treat analysis). Anti-HAV antibody geometric mean titers were 323 and 132 mIU/mL in the 3-dose group and 138 and 67 mIU/mL in the 2-dose group, respectively, 28 (P = 0.03) and 72 weeks (P = 0.05) after the first vaccine dose. There were no serious adverse events associated with the vaccine. Multivariate analysis showed no treatment group effect but indicated that absence of tobacco smoking (odds ratio = 2.92, 95% confidence interval: 1.07 to 7.97; P = 0.04) was an independent predictor of response to HAV vaccine. CONCLUSIONS: In HIV-infected adults, immunogenicity of hepatitis A vaccine is poor. Three doses of vaccine were safe and increased antibody titers. 相似文献
964.
Trends in Injury-related Incidence and Mortality Among Inpatients in Guangdong Province in 1997-2001
LI-PING LI* SHENG WANG# *Injury Prevention Research Center Shantou University Medical College Shantou Guangdong China #School of Public Health Beijing University Beijing China 《Biomedical and environmental sciences : BES》2004,17(3)
INTRODUCTION Today injuries constitute a major public health problem in both developed and developing countries and are a leading cause of years of potential life lost (YPLL) in these countries[1-5]. In recent decades, the mortality rates from infectious … 相似文献
965.
Xiao-lin He Zhi Liu * and Shu-yue Xia Department of Emergency the First Affiliated Hospital China Medical University Shenyang Division of Respirology Department of Medicine Central Hospital of Shenyang Medical College Shenyang 《中国医学科学杂志(英文版)》2004,19(4):252-256
Objective To study endothelial damage by observing changes of circulating endothelial cells (CECs) in blood, coagulation and fibrinolysis index in patients with acute respiratory distress syndrome.Methods CECs were separated by isopycnic centrifugation method in 14 patients with acute lung injury (ALI), 7patients with acute respiratory distress syndrome (ARDS), 10 intensive care unit (ICU) controls, and 15 healthy controls.Plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FG), fibrin degradation products (FDP), and D-dimer were examined simultaneously. Acute physiology and chronic health evaluation (APACHE) Ⅱ and lung injury score (LIS) were recorded to evaluate severity of illness and lung injury.Results (1) The number of CECs in ALI (10.4 ± 2.3 ) and ARDS groups ( 16.1 ± 2.7) was higher than that in the healthy (1.9 ± 0.5) (P < 0.01). In both ALI and ARDS, the number of CECs correlated with APACHE Ⅱ (r = 0.55, P < 0.05 and r =0.62, P < 0.05, respectively) and LIS (r = 0.60, P < 0.05 and r = 0.53, P < 0.05, respectively). CEC number was negatively correlated with PaO2 in ALI and ARDS (r=-0.49, P< 0.05 and r=-0.64, P< 0.05, respectively). (2) The level of FDP and D-dirmer were higher in ALI and ARDS patients than that in ICU and healthy control groups (P<0.05). The level of FG in ARDS group was significantly higher than in the ICU and healthy control groups (P < 0.05). But in ALI group, the level of FG was significantly higher than only healthy control group (P < 0.05).Conclusions Endothelial cell damage occurs in ARDS patients, which may play a major role in the pathophysiology of ARDS. Changes of endothelial cell activation and damage markers, such as CECs, plasma coagulation and fibrinolysis index,to some extent reflect severity of illness and lung injury in ARDS. 相似文献
966.
Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
967.
Eller E Roll S Chen CM Herbarth O Wichmann HE von Berg A Krämer U Mommers M Thijs C Wijga A Brunekreef B Fantini MP Bravi F Forastiere F Porta D Sunyer J Torrent M Høst A Halken S Lødrup Carlsen KC Carlsen KH Wickman M Kull I Wahn U Willich SN Lau S Keil T Heinrich J;Working Group of GALEN--Work Package . Birth Cohorts 《Allergy》2008,63(11):1491-1498
Background: Studies on pet ownership as a risk or protective factor for asthma and allergy show inconsistent results. This may be on account of insufficient adjustment of confounding factors. Aim: The objective of this study was to describe determinants of cat and dog ownership in European families with and without allergies. Methods: Within the EU‐funded network of excellence GA2LEN, we performed meta‐analyses with data from 12 ongoing European birth cohort studies on asthma and allergy. Each of the birth cohort studies enrolled between 485 and 4089 children. Pet ownership, allergic status (asthma, allergic rhinitis, eczema) of parents and siblings, parental education, access to ground floor, and number of people living at home were assessed by questionnaires. Results: Among the 25 056 families from seven European countries cats (14.9%) were more common than dogs (12.0%). Allergic family history significantly reduced the odds to own a cat (adjusted combined random‐effect OR 0.91; 95% CI 0.85–0.99), or dog (0.90; 0.86–0.94). A higher parental educational level had even more pronounced effects on cat (0.84; 0.71–0.98), and dog ownership (0.61; 0.54–0.70). Elder siblings reduced the odds to own cats, but not dogs. Convenient ground access significantly increased the odds, whereas crowding at home was not associated with cat or dog ownership. Conclusions: The chances to own a cat or dog were significantly reduced in allergic families, in parents with a higher educational level, and in homes without convenient ground access. In addition to parental allergies, social and housing factors should be considered as potential confounders in studies on pet exposure and allergic diseases. 相似文献
968.
Piton A Michaud JL Peng H Aradhya S Gauthier J Mottron L Champagne N Lafrenière RG Hamdan FF;SD team Joober R Fombonne E Marineau C Cossette P Dubé MP Haghighi P Drapeau P Barker PA Carbonetto S Rouleau GA 《Human molecular genetics》2008,17(24):3965-3974
In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation (MR) who carries a de novo frameshift Ile367SerfsX6 mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), a gene implicated in calcium-regulated vesicle release and dendrite differentiation. We showed that the function of the resulting truncated IL1RAPL1 protein is severely altered in hippocampal neurons, by measuring its effect on neurite outgrowth activity. We also sequenced the coding region of the close related member IL1RAPL2 and of NCS-1/FREQ, which physically interacts with IL1RAPL1, in a cohort of subjects with autism. The screening failed to identify non-synonymous variant in IL1RAPL2, whereas a rare missense (R102Q) in NCS-1/FREQ was identified in one autistic patient. Furthermore, we identified by comparative genomic hybridization a large intragenic deletion of exons 3-7 of IL1RAPL1 in three brothers with autism and/or MR. This deletion causes a frameshift and the introduction of a premature stop codon, Ala28GlufsX15, at the very beginning of the protein. All together, our results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from MR to high functioning autism. 相似文献
969.
Fätkenheuer G Nelson M Lazzarin A Konourina I Hoepelman AI Lampiris H Hirschel B Tebas P Raffi F Trottier B Bellos N Saag M Cooper DA Westby M Tawadrous M Sullivan JF Ridgway C Dunne MW Felstead S Mayer H van der Ryst E;MOTIVATE MOTIVATE Study Teams 《The New England journal of medicine》2008,359(14):1442-1455
970.