提上睑肌腱膜修复治疗老年性后发性上睑下垂

目的 探讨与运用手术疗法,治疗因内眼手术导致的老年性后发性上睑下垂.方法 采用提上睑肌腱膜缝合术与腱膜折叠术进行修复矫正.结果 32例60眼进行腱膜缝合术,16例32眼进行腱膜折叠术,成功率为90%.结论 本组手术疗法不难看出,提上睑肌膜的修复,其上睑缘位置得到满意的提高,其功能得到强化与巩固,其活动度也相应地增强,得到了与传统的上睑下垂矫正不能达到的效果.     

神经外科意识障碍患者的转运护理

目的 讨论意识障碍患者的安全转运护理.方法 对意识障碍患者的安全护理总结. 结果意识障碍患者院内转运安全. 结论转运前认真评估患者病情,妥善处理病人所需,在转运前加强与接收部门的沟通,准备所需的仪器及药物,指派合格人员随行,以保证意识障碍患者院内转运安全,减少不良事件发生.     

内分泌和化疗对乳腺肿瘤患者干细胞的影响

BACKGROUND:Tumor stem cells are the root of cancer recurrence and metastasis, so clinical researches should focus on the effects of different treatments on tumor stem cells. OBJECTIVE:To explore the effects of endocrine therapy and chemotherapy on stem cells in patients with breast cancer. METHODS:After recovery and cultivation of estrogen receptor-positive human breast cancer cell lines MCF-7, passage 3 cells in logarithmic phase were selected and divided into three groups containing control, estradiol and estradiol with tamoxifen groups. The estradiol group was divided into three subgroups: 10^-7, 10^-8 and 10^-9 mol/L estradiol was added into the medium, respectively; the estradiol with tamoxifen group was divided into three subgroups: 10^-7, 10^-8 and 10^-9 mol/L estradiol with 10^-6 mol/L tamoxifen were added into the medium, respectively. The same amount of absolute ethyl ethanol was added into the medium of control group. Fifteen female patients with late recurrence and metastasis of breast cancer received chemotherapy as recurrence and metastasis group. Another 15 healthy volunteers were selected as healthy control group. RESULTS AND CONCLUSION:The proportion of CD44⁺CD24^-/low cell subsets in the estradiol and estradiol with tamoxifen groups was significantly higher than that of the control group (P < 0.05), and the proportion of CD44⁺CD24^-/low cell subsets in the estradiol group was significantly higher than that of the estradiol with tamoxifen group at the same concentration (P < 0.05). The proportion of CD44+CD24-/low cell subsets had no significant differences among groups at 10 and 20 days of culture (P < 0.05). The proportion of CD44⁺CD24^-/low cell subsets significantly increased in MCF-7 cells after 24-hour intervention with different chemotherapy drugs. But only the proportion of CD44⁺CD24^-/low cell subsets in the paclitaxel and doxorubicin groups was significantly higher than that of the control group after 20-day intervention (P < 0.05). Besides, the proportion of CD44⁺CD24^-/low cell subsets in the peripheral blood of healthy volunteers was significantly lower than that of the recurrence and metastasis group (P < 0.05). Among 15 patients with late recurrence and metastatic of breast cancer, 9 had stable disease, 5 had partial remission, 1 had failed chemotherapy and cancer progression. Moreover, the proportion of CD45^-CD44⁺CD24^-/low cell subsets in the peripheral blood of patients sensitive for chemotherapy was significantly lower than that before treatment (P < 0.05). In conclusion, both endocrine therapy and chemotherapy exert a certain effect on the CD44⁺CD24^-/low cell subsets of breast cancer positive for estrogen receptor. Given that CD44⁺CD24^-/low cell subsets in MCF-7 cells resist chemotherapy drugs, the proportion of CD45^-CD44⁺CD24^-/low cells in the peripheral blood of patients sensitive for chemotherapy is decreased.     

男性全身麻醉病人留置尿管时机对麻醉恢复期的影响

留置尿管是基础护理中最常见的技术操作之一,指在严格无菌操作下,用导尿管经尿道插入膀胱引流尿液的方法,是手术病人一项重要的术前准备,是诊断、治疗各种急、危重病人及手术病人必要的护理措施,也是预防手术病人尿潴留、观察尿量、了解病情的重要措施[1]。以往是在病房为手术病人完成这一操     

单切口腹腔镜前列腺癌根治围手术期护理体会

关键词： 前列腺癌 单切口腹腔镜 根治术 护理 前列腺癌在欧美是最常见的恶性肿瘤之一,在我国比较少见,而近年来发病率有逐渐上升趋势。腹腔镜前列腺癌根治术是近年发展起来的微创外科新技术,国外开展较多 ,国内报道极少,2010年6月–2010年8月我院开展了5例单切口腹腔镜前列腺癌根治切除术,取得了较好的早期疗效,手术顺利其优点如：单切口（辅助小切口）手术可以降低手术切口出血、感染、切口疝的发生率。     

护士对礼仪知识需求的现状及调查分析

目的调查护理人员对文明礼仪知识需求的现状及掌握程度,为针对性培训提供参考依据。方法采用自行设计的问卷,通过抽签法选取150名临床护士进行调查,内容包括临床护士自身整体礼仪知识水平的评价、对礼仪知识的认知、护士学习礼仪知识的意愿、护士对礼仪知识需求的排序。结果临床护士整体礼仪知识水平仍需提高;护士对礼仪知识的学习有强烈的意愿,但缺乏规范化和系统化。结论在职护士礼仪知识掌握的程度与医疗市场的需求仍存在差距,医院需要将此项培训内容列入培训计划,采取灵活多样的培训方法,以提高护士的文明素质,规范礼貌服务的护理行为。     

赤峰地区平衡易位致习惯流产2例报告

染色体平衡易位携带者在人群中占0.47%,本文检出2例,1男1女,表型正常,上染色体平衡易位而致习惯流产。     

浅析新化学实体专利保护

0 引言 随着知识经济的到来和我国加入WTO,药品领域的知识产权保护将越来越受到医药行业乃至全社会的注视。我国自1993-01-01 起实施了修改后的《专利法》,对化学药品给予了专利保护,国务院还发布了《药品行政保护条例》和《中药品种保护条例》。因此,进一步认识药品中新化学实体的专利保护具有一定的现实意义。     

多色流式细胞术检测微小残留病变在CD19-CAR-T桥接allo-HSCT治疗B-ALL患者监测的意义和价值

目的探讨多色流式细胞术(MFC)监测微小残留病变(MRD)在 CD19嵌合抗原受体T细胞(CD19-CAR-T 细胞)治疗后桥接异基因造血干细胞移植(allo-HSCT)治疗难治、复发急性B淋巴细胞白血病(r/r B-ALL)患者过程中的意义和价值。方法收集2019年1月至7月河北燕达陆道培医院收治的r/r B-ALL患者37例, 年龄15(6, 19)岁, 其中男24例, 女13例, 均为经CD19-CAR-T细胞免疫治疗桥接allo-HSCT治疗的患者。采用多色流式细胞技术以胞浆CD79a抗体设B细胞门监测患者在CART治疗前第0天、治疗后第15天、第28天及移植后骨髓、脑脊液样本、组织样本的MRD值评估肿瘤细胞残存以及肿瘤累及位置, 监测CD19阳性B细胞在移植前恢复情况及CD19阳性B细胞恢复距离CAR-T细胞回输天数评估CAR-T细胞实际杀伤效果, 同时进行患者各时间点外周血CAR-T细胞计数等。采用Kaplan-Meier法及Log-rank检验分析单因素累积生存差异。结果 (1)37例患者中8例死亡, 29例存活。5例患者移植后复发, 其中复发患者4例死亡, 1例存活。(...     

晚期乳腺癌患者实施个性化护理的效果

目的总结晚期乳腺癌患者的护理方案以及护理体会。方法选择我院收治住院治疗的80例晚期乳腺癌患者作为研究对象,根据护理方法的不同,将其随机分为对照组(n=40)与观察组(n=40)。对照组采取常规护理;观察组采取个性化护理。伦理委员会批准且参与实验的晚期乳腺癌患者、家属知情同意。对比对照组、观察组晚期乳腺癌患者生活质量评分以及焦虑、抑郁情绪评分情况。结果观察组晚期乳腺癌患者生活质量评分高于对照组,观察组患者的焦虑、抑郁负性情绪评分低于对照组,差异均有统计学意义(P0.05)。结论晚期乳腺癌患者治疗期间配合个性化护理干预可以明显改善乳腺癌患者情绪、生活质量,是提高患者生存质量的关键。