Preparation and degradation characteristic study of bone repair composite of DL—polylactic acid／hydroxyapatite／decalcifying bone matrix

Objective:To explore the preparative method and study the degradation characteristics of bone repair composite of DL-polyactic acid(PDLLA) /hydroxyapatite(HA)/decalcifying bone matrix(DBM) in vitro.Methods:An emulsion blend method was developed to prepare the composite of PDLLA/HA/DBM in weight ratio of PDLLA:HA:DBM=1.2-2:1.5:1.The dynamic changes of weight,biomechanical property and pH value of PDLLA/HA/DBM and PDLLA in phosphate buffered saline(PBS,pH7.4)were studied respectively through degradation tests in vitro.Results:Without being heated,PDLLA,HA and DBM could be synthesized with the emulsion blend method as bone composite of PDLLA/HA/DBM,wich had both osteoconductive and osteoinductive effects.The diameter of the aperture was 100-400μm and the gap rate was 71.3%.During degradation,the pH value of PDLLA solution decreased lightly within 2 weeks,but decreased obviously at the end of 4 weeks and the value was 4.0 .While the pH value of PDLLA/HA/DBM kept quite steady and was 6.4 at the end of 12 weeks.The weight of PDLLA changed little within 4 weeks,then changed obviously and was 50% of its initial weight at the end of 12 weeks.While the weight of PDLLA/HA/DBM changed little within 5 weeks ,then changed obviously and was 60% of the initial weight at the end of 12 weeks.The initial biomechanical strength of PDLLA was 1.33 MPa, decreased little within 3 weeks, then changed obviously and kept at 0.11 MPa at the end of 12 weeks.The initial biomechanical strength of PDLLA/HA/DBM was 1.7 MPa, decreased little within 4 weeks, then changed obviously and kept at 0.21 MPa at the end of 12 weeks.Conclusions:The emulsion blend method is a new method to prepare bone repair materials.As a new bone repair material,PDLLA/HA/DBM is more suitable for regeneration and cell implantation,and the environment during its degradation is advantageous to the growth of bone cells.     

咪唑斯汀治疗慢性荨麻疹临床疗效观察

咪唑斯汀(皿治林，Mizolastine)具有抗组胺和抗过敏性炎症双重作用的新抗组胺药，西安杨森制药有限公司生产。为评价咪唑斯汀治疗慢性荨麻疹的疗效及安全性，我科2002年6月～2003年4月采用咪唑斯汀治疗慢性荨麻疹．180例，疗效满意报告如下。     

社会化养老机构中的老年人主观幸福感和抑郁情绪研究

目的探讨社会化养老机构中的老年人主观幸福感、抑郁情绪及其影响因素。方法采用纽芬兰纪念大学幸福度量表、抑郁量表、日常生活能力量表及自制调查表对生活在老年公寓和社区服务家庭中各138例情况类似老年人的主观幸福感和抑郁情况、日常生活能力等因素进行对比分析。结果住老年公寓和在家庭中两组老年人的总幸福度、抑郁情绪总均分值无统计学差异(P>005);老年公寓和家庭中影响老年人心理状态的因素顺位不同。结论条件好、服务功能完善的社会化养老机构中老年人有较高的主观幸福感,老年公寓是一种可取的社会化养老方式。     

胃黏膜活检中各型腺癌的临床病理研究

目的　分析胃黏膜活检中腺癌的病变特点 ,总结其临床病理特征。方法　通过HE染色法对 2 3 8例胃腺癌标本进行组织学分类 ,部分病例用组织化学PAS、AB染色法及免疫组织化学方法 (Keratin、EMA、LCA等 )来进行诊断及鉴别诊断。结果　根据组织学特点 ,将癌组织分成乳头状腺癌、管状腺癌、黏液腺癌及黏液细胞癌。每种类型的腺癌细胞形态、排列方式均有所不同。结论　胃腺癌的形态特点具有相对特殊性 ,掌握其特点并与一些疾病进行鉴别诊断可以减少误诊、漏诊。     

现代急诊护理文化建设初探

目的 研究现代急诊护理文化建设，发展急诊护理。方法 制定急诊护士职业道德、服务要求、工作标准，实施急救绿色通道服务系列措施，按国际急救服务体系(EMSS)和模拟急救法培训急诊专科护士。结果 确立现代急诊护理理念，建立急救绿色通道、创建急诊护理服务品牌，培养一支急诊专科护士人才队伍。结论 急诊护理文化建设，提高了现代急诊护理质量与水平。     

基质金属蛋白酶2及CD147在食管鳞状细胞癌中的表达及意义

目的：探讨食管鳞癌基质金属蛋白酶2(MMP-2)和CD147表达及其与癌浸润转移的关系。方法：应用免疫组化S-P法观察70例食管鳞癌组织中MMP-2和CD147的表达，并探讨其与临床病理资料的关系。结果：在低分化、中和高分化食管鳞癌中MMP-2和CD147的阳性率分别为90．5％、87．8％及81．0％、73．5％。在食管鳞癌中．MMP-2及CD147的表达均与食管鳞癌的浸润深度有关，与分化程度无明显关联；有淋巴结转移的病例阳性表达率明显高于无淋巴结转移组。结论：MMP-2和CD147均与食管鳞癌的浸润深度及淋巴结转移有关。     

中西医结合治疗跖疣18例

跖疣是发生于足底的寻常疣。初起为角质小丘疹，逐渐增至黄豆大或褐黄胼胝样斑块或扁平丘疹，表面粗糙不平，中央微凹，边缘绕以稍高的角质环，疼痛明显。局部治疗方法很多，但缺乏一种非常理想有效的治疗方法。又因为跖疣在足底部，长期处于受压以及潮湿不透气环境之中，所以治疗上更加