细胞色素P450 CYP1A1基因多态与鼻咽癌易感性的关联分析

Objective To investigate the association between CYP1A1 gene polymorphisms and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families through family-based association study. Methods A total of 457 Cantonese nuclear families, consisting of 2134 members, were recruited as subjects. Each family included two parents and at least one offspring with nasopharyngeal carcinoma. Two single nucleotide polymorphisms (SNP) in CYP1A1 named m1 (rs4646903) and m2 (rs1048943) , were genotyped by PCR-RFLP assay and verified by directly sequencing. The genotype data were analyzed with family-based association test (FBAT) software to check the linkage and association between the two genetic markers and susceptibility of nasopharyngeal carcinoma. Results FBAT analysis showed that the minor allele frequencies (MAF) of the two SN P were 0. 442 (C) and 0. 339 (G) respectively. For m1 polymorphism in CYP1A1 gene was not significantly associated with nasopharyngeal carcinoma in our study population whether stratified with VCA-IgA or not (without stratification : X2=2. 399, P=0. 301 ; with stratification : Iow-titer group (VCA-IgA<1 : 80), MAF=0. 457 (C), X2=1.221, P=0.543 ; high-titer group (VCA-IgA ≥1 : 80), MAF=0. 427 (C), X2=2. 832, P=0. 243). For m2 polymorphism, when VCA-IgA<1 : 80, the G allele showed decreased transmission under additive and dominant model (MAF=0. 347 (G) ; Zadditive=-2. 120,Padditive=0. 034;Zdominant=-2. 303,Pdominant=0.021)and a boundary P value was got with global statistic (X2=5. 394, P=0. 067). Haplotype TG (0. 057), constructed by ml and m2, might decrease nasophargneal carcinoma risk (Z=-2. 002,P=0. 045). A boundary P value was also got with global statistic (X2=7. 067 ,P=0. 070). Conclusion There was no statistical significance between ml polymorphism and susceptibility of nasopharyngeal carcinoma in Cantonese nuclear families. And this study showed that m2 polymorphism might associated with the decrease of nasopharyngeal carcinoma in Cantonese nuclear families.     

先矫形后针刺法治疗周围性面神经麻痹100例临床观察

目的：观察不同针刺方法对周围性面神经麻痹的疗效。方法：将200例周围性面神经麻痹患者随机分为2组,分别采用先矫形后针刺法（治疗组）和常规针刺法（对照组）进行治疗。结果：治疗组愈显率为97.0%,对照组愈显率为78.0%,治疗组疗效优于对照组（P〈0.01）。结论：先矫形后针刺法治疗周围性面神经麻痹优于常规针刺法。     

肺动脉内膜剥脱术联合抗肿瘤治疗肺动脉肉瘤1例并文献复习

<正>肺动脉肉瘤是一种极罕见的恶性肿瘤，病变多起源于肺动脉主干，常累及分支动脉、肺动脉瓣和右心。临床和影像学表现缺乏特异性，早期诊断困难，易误诊为肺血栓栓塞症，从而延误诊治。该病明确诊断依靠活组织病理检查，目前外科手术是主要的治疗手段，联合术后辅助治疗可能会改善患者的预后。本文结合1例肺动脉内膜剥脱术联合抗肿瘤治疗肺动脉肉瘤，患者的临床资料并复习相关文献，对肺动脉肉瘤的临床表现、诊治及预后进行分析，以提高临床医师对该病的诊疗水平。