胃良性和恶性病变组织中β-半乳糖凝集素3和接骨木凝集素的表达及其临床病理意义

Objective To study the expressive levels of galectin-3(gal-3) and sambucus nigra agglutinin (SNA) and their clinicopathological significance in the benign and malignant lesions of stomach. Methods EnVisonTM immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastastic foci of lymph nodes(n=36), and different types of benign lesions(n=80). Results The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions (P<0.05, P<0.01). The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells. No difference was found between the primary foci and metastatic foci in gal-3 and SNA expressions (P>0.05). The positive rates of gal-3 and SNA were significantly lower in histologic grade Ⅱ, infitrating depth T1,T2 and no-metastasis of regional lymph node than those in histologic grade Ⅲ, Ⅳ, infitrating depth T3,T4 and metastasis of lymph node in gastric cancer(P<0.05). The positive rates of gal-3 and SNA were higher in lymphnede metastatic site N1 and no-metastasis of distant organs than those in lymphnede metastatic site N2, N3 and metastasis of distant organs, but no significant difference was found (P>0.05). The consistence was found between the expression of gal-3 and SNA in gastric cancer tissues (χ2=6.59,P<0.05). Conclusions The expressive levels of gal-3 and SNA may be important molecular markers of lectins for reflecting the carcinogenesis, progression and biological behaviors in gastric cancer.     

结肠囊状淋巴管瘤1例

1病例资料 患者,男,53岁,因纤维结肠镜发现结肠肿块1月入院,无大便性状及习惯改变,无发热、黑便等症状。体查：腹部平软,未扪及包块,全腹无压痛及反跳痛,肠鸣音正常。血生化检查、肝肾功能正常,大便常规未见异常,隐血试验（一）。肠镜示：距肛门55cm处有一直径约3cm肿块突向肠内,表面分叶、糜烂,有水波感。全麻下行乙状结肠、降结肠部分切除术,     

论大面积烧伤感染期的诊治特点

目的：总结皮肤原位再生医疗技术在大面积特重度烧伤患者感染期的救治特点，提高烧伤皮肤原位再生医疗技术在大面积烧伤中的救治水平。方法：作者9年来分别在全国23个省市会诊抢救烧伤面积在90％以上的烧伤患者62例，均采用烧伤皮肤再生疗法救治，抢救成功最大烧伤面积100％＋口腔黏膜、食道黏膜烫伤。结果：62例严重烧伤患者，治愈60例，死亡2例，其中1例死于入院48h内暴发脓毒性休克，1例死于重度吸入性损伤继发肺部感染。结论：总结皮肤原位再生医疗技术在严重烧伤感染期的救治特点，包括感染期观察的三个“3”阶段规律和四项观测指标，强调了预防烧伤感染的原则是早期应用抗生素，在确诊感染后应及时、高效、足量的联合应用敏感抗生素，同时加强清除创面液化物等皮肤原位再生医疗技术的规范化创面处理。     

影像学技术与免疫学技术在评估肝泡型包虫病病灶代谢活性中的现状研究

肝泡型包虫病(HAE)是一种寄生性人畜共患病.此病患者若未接受系统性治疗或治疗不及时,可危及其生命.HAE患者在接受治疗后其病情的复发率较高.临床上在对此病患者进行治疗的过程中,应采取有效的手段监测其病灶的代谢活性,以便于调整治疗方案,提高其疗效,降低其病情的复发率.本文主要是论述用影像学技术与免疫学技术评估HAE病灶...     

有限内固定结合组合半环式外固定器治疗Pilon骨折

Pilon骨折是指波及胫骨远端关节面的骨折，常导致关节面压缩及胫骨下段粉碎。同时伴有软组织严重损伤，治疗非常困难，目前对此骨折治疗尚未统一认识。本院自2000年1月至2007年12月，采用有限内固定组合半环式外固定治疗18例．取得满意效果。     

钛质网笼内植物加前路带锁钢板对颈椎稳定性的生物力学评价

目的评价颈椎在植入颈椎钛质网笼内植物和植入钛质网笼内植物辅助AO前路带锁钢板内固定两者的生物力学稳定性.方法测量6例新鲜人颈椎骨骼韧带标本(C2～T1)在正常、C5椎体次全切除减压后植钛质网笼内植物、植钛质网笼内植物后辅助AO前路带锁钢板内固定三种工况下C4～C6节段的三维运动数据,并做统计学处理.结果6例颈椎标本C4～C6节段在正常、植钛质网笼内植物、植钛质网笼内植物加AO前路钢板三种工况下,前屈/后伸、左/右侧弯、左/右轴向旋转的运动范围(ROM)平均值(°)分别为14.12/12.94、13.39/13.11、9.77/10.72;9.70/14.42、8.94/8.61、7.65/8.09和4.39/1.36、4.08/4.19、3.46/3.63.结论颈椎减压、植入钛质网笼后在后伸运动时的稳定性明显不足;辅助AO前路带锁钢板内固定后在各个方向的稳定性都显著增强,可满足临床应用的要求.     

嗜酸性膀胱炎3例报告并文献复习

目的:探讨嗜酸性膀胱炎的临床诊断和诊治方法.方法:回顾性分析3例嗜酸性膀胱炎患者临床资料,并结合相关文献综合分析讨论本病病因学、诊断和治疗.结果:3例患者起病均有膀胱下尿路刺激症状、镜下或肉眼血尿,B超见膀胱壁增厚和(或)膀胱新生物.经膀胱镜检查并活检确诊为嗜酸性膀胱炎.其中1例患者经电切后口服抗感染、抗过敏药物后好转,1例考虑为寄生虫感染患者加用抗寄生虫药物后好转;1例病灶电切后反复发作,经仔细追问病史,患者有虾蟹过敏史,经抗过敏及禁食虾蟹后未再发作.随访18～128个月,平均随访72个月,预后良好.结论:嗜酸性膀胱炎确诊需要膀胱镜检查及组织活检.治疗上以消除病因,切除病变组织和抗炎、抗过敏等治疗方法.本病容易复发,需要长期强制性随访.     

美宝湿润烧伤膏再生疗法与磺胺嘧啶银霜抗炎疗法治疗大面积烧伤的比较研究

目的：比较美宝湿润烧伤膏再生疗法与磺胺嘧啶银霜抗炎疗法治疗大面积烧伤的疗效.方法：选择62例大面积烧伤病人,随机分为两组,烧伤创面分别采用美宝湿润烧伤膏再生疗法（实验组）与磺胺嘧啶银霜抗炎疗法（对照组）治疗,观察两组病人休克期情况、不同深度烧伤创面的愈合时间、感染发生率、手术植皮例数及瘢痕发生率.结果：实验组病人休克期补液量明显比对照组少、尿量多于对照组（P＜0.05）;休克征象发生率比对照组少,但差异无显著性（P＞0.05）.实验组创面愈合时间、感染率、手术植皮比例及瘢痕出现率均明显低于对照组（P＜0.05）.结论：在大面积烧伤治疗中,美宝湿润烧伤膏再生疗法疗效优于磺胺嘧啶银霜抗炎疗法.     

胃良性和恶性病变组织中β-半乳糖凝集素3和接骨木凝集素的表达及其临床病理意义

Objective To study the expressive levels of galectin-3(gal-3) and sambucus nigra agglutinin (SNA) and their clinicopathological significance in the benign and malignant lesions of stomach. Methods EnVisonTM immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastastic foci of lymph nodes(n=36), and different types of benign lesions(n=80). Results The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions (P<0.05, P<0.01). The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells. No difference was found between the primary foci and metastatic foci in gal-3 and SNA expressions (P>0.05). The positive rates of gal-3 and SNA were significantly lower in histologic grade Ⅱ, infitrating depth T1,T2 and no-metastasis of regional lymph node than those in histologic grade Ⅲ, Ⅳ, infitrating depth T3,T4 and metastasis of lymph node in gastric cancer(P<0.05). The positive rates of gal-3 and SNA were higher in lymphnede metastatic site N1 and no-metastasis of distant organs than those in lymphnede metastatic site N2, N3 and metastasis of distant organs, but no significant difference was found (P>0.05). The consistence was found between the expression of gal-3 and SNA in gastric cancer tissues (χ2=6.59,P<0.05). Conclusions The expressive levels of gal-3 and SNA may be important molecular markers of lectins for reflecting the carcinogenesis, progression and biological behaviors in gastric cancer.     

弧形切割吻合器在低位直肠癌保肛术中的应用体会

目的 评价弧形切割吻合器(Contour TM)在低位直肠癌保肛术中的应用价值.方法 回顾性分析2006年4月至2007年4月16例低位直肠癌保肛术中应用新型弧形切割吻合器的患者的临床资料.结果 全组术中直肠闭合和结直肠吻合过程均顺利,无手术死亡病例.未发生吻合口瘘和吻合口狭窄,无局部复发者.结论 弧形切割吻合器的应用进一步提高了低位直肠癌保肛手术的成功率.