中西医结合治疗紫癜性肾炎26例临床观察

过敏性紫癜是一种常见的血管变态反应性疾病,约有12%～40%合并肾损害,出现不同程度的血尿、蛋白尿。近几年来,我们运用中药联合低分子肝素治疗紫癜性肾炎26例疗效确切,现报道如下:     

通心络胶囊联合硫酸氢氯吡格雷对急性心肌梗死经皮冠状动脉介入治疗(PCI)术后患者的临床疗效

目的:观察通心络胶囊联合硫酸氢氯吡格雷对急性心肌梗死经皮冠状动脉介入治疗(PCI)术后心脏功能、炎症指标、血液流变学的影响.方法:选取2018年7月至2020年7月在河北以岭医院心内科治疗的急性心肌梗死(AMI)行PCI术后患者100例作为研究对象,随机分为观察组和对照组,每组50例.对照组给予心内科常规治疗和硫酸氢氯...     

润燥灵胶囊加腮腺内注射治疗干燥综合征的疗效观察

目的探讨腮腺内直接注射用药对原发性干燥综合征(Sjogren’ssyndrome,SS)的疗效与作用机制,验证局部注射用药对已遭免疫反应破坏的腮腺腺体形态结构的修复和未损腺泡保护作用以及腮腺分泌唾液功能的改善作用。方法将已确诊为SS的患者分为对照组和治疗组,两组均用相同剂量的中成药润燥灵胶囊治疗,治疗组加直接腮腺内注射药物治疗,观察治疗前后两组腮腺结构、形态学表现和功能改善情况。结果两组在形态结构上的变化有显著差异(t=1.67,P<0.01),两组分泌唾液的功能比较差异有显著性意义(t=2.31,P<0.001)。结论腮腺内直接注射药物治疗能够修复免疫性炎症浸润但腺体尚未彻底破坏的腮腺腺泡和导管,能有效改善腮腺分泌唾液的功能。     

肌炎灵对多发性肌炎动物模型血清抗体及T淋巴细胞增殖的影响

目的:观察肌炎灵胶囊对多发性肌炎动物模型体液免疫和细胞免疫的影响,以探讨其作用机制.方法:利用豚鼠肌浆球蛋白多点免疫Lewis大鼠造成肌炎模型,在此基础上给药,观察动物血清中特异性抗体、ENA多肽抗体、淋巴细胞增殖情况,且和强的松对照.结果:肌炎灵可以显著抑制大鼠血清特异性抗体含量,抑制由Myosin和ConA诱导的淋巴细胞增殖.结论:同强的松一样,肌炎灵对非特异性和特异性细胞免疫及体液免疫起抑制作用,以此发挥疗效.     

"脉络-血管系统病"辨证诊断标准

1前言“脉络-血管系统病”概念是基于中医学对“脉”的论述,探讨脉络病变与血管病变相关性而提出。《内经》记载:“若八尺之士,皮肉在此,外可度量切循而得之,其死可解剖而视之……脉之长短,血之清浊,皆有大数”,可见中医对“脉”的认识基于解剖学的发展,在形态学上与西医学血管     

Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction

<正>Objective:To observe the changes of vascular endothelial functions and general neuroendocrine -immunity(NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness.Methods:A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group,50 rats in each group.The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks.Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment.Furthermore,their internal relevance was analyzed by the method of canonical correlation analysis.Results:The vascular endothelial structure and function were obviously injured in the model group.Compared with the control group,the chemical signal molecules,such as 5-hydroxytryptamine (5-HT),corticosterone(CORT),triiodothyronine(T3),tetraiodothyronine(T4),angiotensinⅡ(AngⅡ), interleukin-1(IL-1),and tumor necrosis factor-α(TNF-α) in peripheral blood of the model group(n=43) were changed significantly(P0.05 or P0.01).Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network.Conclusions:Comfortbased lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other,and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction,even diseases of the blood vessel.     

骑跨中后颅窝哑铃型三叉神经鞘瘤的手术治疗

目的探讨两种入路切除向中后颅窝侵犯的哑铃型三叉神经鞘瘤的手术效果。方法对两种入路治疗的24例中后颅窝哑铃型三叉神经鞘瘤的手术效果进行分析,手术入路选择为幕上额颞开颅为基础辅以硬膜间（Dolenc）入路,幕下开颅枕下乙状窦后开颅为基础的硬膜下入路。结果经幕上组入路共16例,全切7例,次全切9例,经幕下组入路共8例,肿瘤全切6例,次全切2例。结论额颞硬膜间（Dolenc）入路残存率、死亡率较经枕下乙状窦后入路低,但肿瘤全切率及神经功能保留率较幕下入路低。     

"脉络-血管系统病"脑络瘀阻证候量化诊断标准研究

脑动脉硬化症是全身动脉硬化的一部分,系指由脑动脉粥样硬化、小动脉硬化、细动脉透明变性等脑动脉变性所引起的脑功能障碍证候群。中医学文献古籍虽无脑动脉硬化症的病名,但类似本病的记载散见于“眩晕”、“健忘”、“不寐”、“虚损”等病中。目前有不少专家提出脑动脉硬化症的辨证分型施治,但均未形成统一的标准。笔者所在课题组从事络病理论指导血管病防治的基础研究,通过对中医文献“脉”概念分析,基于“脉络—血管系统”解剖形态同一性提出“脉络—血管系统病”概念[1],就脑动脉硬化症而言,其基本病理环节为脑络瘀阻。为进一步从络病…     

综合疗法治疗腹泻型肠易激综合征

目的：观察综合疗法治疗腹泻型肠易激综合征（IBS）的临床疗效．方法：将临床、内镜确诊为符合罗马亚诊断标准的腹泻型IBS患者72例分为治疗组38例，对照组34例，二组均采用口服心痛定治疗，此外治疗组加用认知疗法，口服中药。结果：治疗组与对照组近期治愈率分别73．7％、35．3％（P〈0．01），总有效率分别为89．5％、58．8％（P〈0．05），近期治愈患者一年后复发率分别为3．6％、33．3％（P〈0．05％）。结论：综合疗法治疗IBS具有疗效佳，复发率低，副作用小。