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??Objective    To evaluate the cytotoxicity?? biocompatibility and biological safety of PGMA pre-impregnated quartz fiber in vitro?? providing scientific basis for clinical application. Methods    According to standard of GBT16886.5-2003 and YYT0268-2008 documents?? the cellular cultivation and cytotoxicity test in vitro were conducted to evaluate the target materials on the morphology?? growth and proliferation of cultured cells ??L929 and GE1??. Results        The range of cell relative growth rate ??RGR?? of 50% and 100% extraction of non-polymerized composite were 44.59%-65.66% ??L929?? and 52.06%-62.86% ??GE1???? and the cytotoxicity was grade 2-3. The range of cell relative growth rate ??RGR?? of 50% and 100% extraction of polymerized composite were 90.56%-100.89% ??L929?? and 89.99%-101.21% ??GE1???? and the cytotoxicity was grade 0-1. Conclusion    Polymerized PGMA pre-impregnated quartz fiber is safe and fit for the clinical application.     

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??Dentin hypersensitivity is a kind of common symptom??and it is also a hard nut to crack in clinics because of the complexity of its pathogenesis and the diversity of its clinical manifestation. Besides??the effect of treatment??especially the long-term curative effect??is not ideal??so this article intended to make a summary about its pathogenesis??principle of treatment and therapeutic methods used in recent years.     

单纯性肥胖外周血单核/巨噬细胞趋化因子与胰岛素抵抗的相关性研究

了解单纯性肥胖儿童外周血单核/巨噬细胞趋化因子与胰岛素抵抗相关参数的关系。方法　2006年5月至2008年5月广西医科大学第一附属医院儿科70 例确诊为单纯性肥胖儿童作为研究对象,30名健康体检儿童作为健康对照组。流式细胞仪测定外周血单核细胞CD68阳性率;酶联免疫吸附（ELISA）法测定血浆巨 噬细胞炎性蛋白-1α（MIP-1α）、单核细胞趋化蛋白-1（MCP-1）水平;放射免疫分析（RIA）法测定血浆脂联素（ADPN）、血浆胰岛素（Ins）浓度,计算体质 指数（BMI）,按HOMA模型计算胰岛素抵抗指数（InRI）,并与相关变量进行Pearson相关分析或偏相关分析。结果　单纯性肥胖组血浆MIP-1α、MCP-1水平高于 健康对照组,两组比较差异有统计学意义（P < 0.05）。两组外周血CD68阳性率比较差异无统计学意义（P > 0.05）。两组InRI比较差异有统计学意义 （P < 0.05）。单纯性肥胖组血浆MIP-1α、MCP-1水平分别与BMI、腰围（WC）和InRI呈正相关 （P < 0.05）。血ADPN分别与BMI、WC和InRI呈负相关（P < 0.05）。外 周血单个核细胞CD68阳性率与BMI、WC和InRI无相关性（ P > 0.05）。结论　单纯性肥胖患儿体内存在低程度炎症反应,肥胖儿童外周血单核/巨噬细胞趋化因子 与胰岛素抵抗及中心性肥胖相关,可以作为肥胖相关疾病的早期预测指标之一。     

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??Abstract??Objective To make doctor perform operation accurately on patients with dentomaxillofacial deformity by preoperative simulation based on digital data which was collected by digital software. Methods Fifteen patients had previously undergone 3-dimensional computed tomography and the data from CT scan were input into digital software. We used the software to simulate operations preoperatively including fixing point??osteotomies and movements of jaw bones. The collected information from software was applied to actual operations. Results All the operations had been completed successfully without serious complication. The patients were satisfied with the effect of operation 6 months after operation??with a satisfaction rate of 93.3%. Conclusion The digital simulation technique is a precise method which provides practical and effective basis for establishing the preoperative planning of individual optimal surgical procedure for patients with dentomaxillofacial deformities in orthognathic surgery.     

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??Objective    To explore the relationship between chronic periodontitis and cytokine interleukin-8 ??IL-8?? by literature review. Methods    The CNKI??Wanfang database??PubMed retrieval platform and Embase database were searched by computer. The research papers on the level of interleukin-8 in chronic periodontitis were collected. The retrieval time was up to 2016??screen literature according to the inclusion and exclusion criteria??use Stata12.0 software for meta analysis. Results    The level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was significantly higher than that in normal controls??P??0.05??. In the Asian population?? the level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was higher than that in normal controls??P??0.05??. In the western population??there was no difference in the level of IL-8 in gingival crevicular fluid between patients with chronic periodontitis and normal controls??P??0.05??. Conclusion    There is a significant difference in chemokines interleukin-8 between patients with chronic periodontitis and normal controls in the Asian population. Chemokines interleukin-8 may increase the risk of chronic periodontitis.     

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??Objective    To study the role of the CCR5 antagonists Maraviroc in the migration??chemotaxis??invasion and proliferation of human salivary adenoid cystic carcinoma. Methods    Scratches??migration??invasion and MTT assays were performed to detect the migration??chemotaxis??invasion and proliferation of SACC-83 and SACC-LM in vitro. Results    Compared with control group, the experimental group which was pretreated by CCR5 inhibitor Maraviroc had lower recuperability in cell scratch model. The number of cells which were blocked by inhibitor decreased significantly on the lower surface of the filters which were fixed in methanol in migration and invasion assays. And proliferation experiment results show that the multiplication capacity of SACC-83 and SACC-LM were obviously inhibited by Maraviroc. Conclusion    Maraviroc may be a kind of new targeted anti-tumor drugs and small-molecule antagonists of CCR5 could inhibit the development of salivary gland adenoid cystic carcinoma.     

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?? Sjögren syndrome??SS??is classified as primary Sjögren syndrome??pSS??and secondary Sjögren syndrome??sSS??. It is an autoimmune exocrinopathy characterised by lymphocytic infiltration of exocrine glands in multiple sites??including both lacrimal and salivary glands??so the patients often suffer from dry mouth and dry eyes. Now the pathogeny and its pathogenesis is still  under study??and this review will elaborate from the aspects of cytokines??antibody??gene??virus and so on.     

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??Objective    To systematically evaluate the effect of iRoot SP and AH Plus paste in the treatment of root canal. Methods    Online databases including PubMed??EMBASE??the Cochrane Library??Web of Knowledge??and Chinese databases ??Wanfang database??VIP and CNKI?? were searched systematically up to February 2017. Randomized controlled trials and high-quality comparative studies were considered eligible for inclusion. Two qualified reviewers reviewed the original articles??evaluating qualities of articles??and extracting data independently. After heterogeneity test??Meta-analysis was performed. Results    In total??seven original clinical controlled trials were included??containing 493 teeth. iRoot SP paste could improve the immediate root canal quality ??OR=0.30??95%CI????0.10 ~ 0.85?????reduce the rate of postoperative pain ??OR=0.23??95%CI????0.06 ~ 0.89?????and decrease the apical leakage ??WMD=-0.13??95%CI????-0.22 ~ -0.05????. Conclusion    iRoot SP paste in root canal therapy can significantly alleviate pain??and the long-term curative effect is good??has better biological compatibility??which is an ideal root canal filling material. Because of the small number of the literatures included??which are all in China??it is necessary to include large sample??multicenter??randomized??double-blind??placebo-controlled trails to further confirm the clinical effect.     

“保胆”理念正误

胆囊切除术是公认的胆囊良性疾病的治愈手段，国内外学术界对于手术适应证和手术时机已有明确共识。近年来，“保胆手术”治疗胆囊良性疾病颇受热议，一些医生将“保护胆囊”的学术观点等同于“保留胆囊”的手术技术，这种误解可能导致病人出现差异性的预后。因此，临床医师应明晰“保护胆囊”理念与“保胆手术”的差别，对胆囊良性疾病的诊疗原则有正确的理解和应用。