9th month (P<0.05).There was a significant di

n cognition ability at 9th month too (P<0.05).Conclusion The baby touch that begins at early time after birth may benefit the neurological and psychological development of the infants and has a long-based effect.Baby touch Intelligence development Different phase0中国全科医学Chinese General Practice36-37R174E055;E069;72;2;EE055_72;E069_2;郭建华000900030001;000900030008000200010003;0009000300040015000230-31影响婴儿出生体重的高危因素分析张勇,王燕,朱鹃,范钦颖中日友好医院预防保健科 ,中日友好医院预防保健科 ,中日友好医院预防保健科 ,中日友好医院预防保健科 100029北京市,100029北京市,100029北京市,100029     

血制品与止血药同时输注所致过敏性休克的救治体会

病例：单某，男，35岁，农民，住院号：117441。患者因右肱骨干骨折并神经损伤术后骨折未愈合，内固定钢板折弯，桡神经损伤于2002年3月11日收住院。入院体查：神清，精神好，双肺呼吸音清，未闻及干湿性罗音，心界不大，律齐，各瓣膜区未闻及杂音，腹软无压痛及反跳痛，肝脾未及，双下肢不肿。专科检查：右上臂前外侧有一长约10cm的手术瘢痕无     

Kongenitaler Tumor des temporalen Lidwinkels

Ohne Zusammenfassung     

Autologous bone marrow stem cell or peripheral blood endothelial progenitor cell therapy in patients with peripheral limb ischaemia

No effective medical therapies have been developed sofar to enhance blood flow in the legs of patients with peripheral arterial disease (PAD). For patients with limb threatening ischaemia the only option for relief of rest pain or gangraena is amputation. There is evidence in experimental and clinical studies that adult bone marrow-derived stem cells and endothelial progenitor cells participate in the development of new blood vessels, called neoangiogenesis or neovascularization. Clinical results induced by autologous bone marrow stem cells or angiogenic growth/differentiation factors in end-stage patients with PAD are summarized. Considering the relatively few number of patients treated by angiogenic therapy, the interpretation of clinical results needs cautiousness.     

Stabilisation of periprosthetic fractures with angular stable internal fixation: a report of 13 cases

Introduction: Periprosthetic fractures of the femur present a challenging surgical problem. The aim of this study was to retrospectively evaluate the outcome of periprosthetic fractures stabilised with an angular stable, less invasive stabilisation system (LISS). Patients and methods: Thirteen patients (ten total hip-, two total knee-, one total hip- and knee-arthroplasty) with periprosthetic fractures were treated with the LISS internal fixator (in ten cases minimal invasive). Six patients had previous operations due to periprosthetic fractures. The average follow-up period was 20 months, follow-up rate 85%. Results: All fractures showed radiographic fracture healing without implant loosening. Except one patient, all patients had returned to their pre-operative activity level. No early post-operative complications were seen. There was one implant failure after 4 months and two cases of malunion. Conclusion: The cases showed the internal fixator to be effective for the stabilisation of periprosthetic fractures, even in cases of poor bone quality with good functional outcomes. The internal fixator, with the option of minimal invasive application, is the preferred method of osteosynthesis in periprosthetic fractures.     

Repair of superficial osteochondral defects with an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results

OBJECTIVE: To compare four different implantation modalities for the repair of superficial osteochondral defects in a caprine model using autologous, scaffold-free, engineered cartilage constructs, and to describe the short-term outcome of successfully implanted constructs. METHODS: Scaffold-free, autologous cartilage constructs were implanted within superficial osteochondral defects created in the stifle joints of nine adult goats. The implants were distributed between four 6-mm-diameter superficial osteochondral defects created in the trochlea femoris and secured in the defect using a covering periosteal flap (PF) alone or in combination with adhesives (platelet-rich plasma (PRP) or fibrin), or using PRP alone. Eight weeks after implantation surgery, the animals were killed. The defect sites were excised and subjected to macroscopic and histopathologic analyses. RESULTS: At 8 weeks, implants that had been held in place exclusively with a PF were well integrated both laterally and basally. The repair tissue manifested an architecture similar to that of hyaline articular cartilage. However, most of the implants that had been glued in place in the absence of a PF were lost during the initial 4-week phase of restricted joint movement. The use of human fibrin glue (FG) led to massive cell infiltration of the subchondral bone. CONCLUSIONS: The implantation of autologous, scaffold-free, engineered cartilage constructs might best be performed beneath a PF without the use of tissue adhesives. Successfully implanted constructs showed hyaline-like characteristics in adult goats within 2 months. Long-term animal studies and pilot clinical trials are now needed to evaluate the efficacy of this treatment strategy.     

Detection of interleukin 6 mRNA by RT-PCR in vaginal secretions: association with preterm delivery and neonatal infection in women with preterm labour and intact membranes

OBJECTIVE: To find a biological marker associated with preterm delivery or neonatal infection in pregnant women with preterm labour and intact membranes. STUDY DESIGN: Cervical secretions were collected from 286 women hospitalized for preterm labour with intact membranes at 24-34 weeks' gestation. The outcomes studied were delivery before 33 and 35 weeks' gestation, chorioamnionitis, and neonatal infection, and their association with the presence of IL-6 mRNA in cervical secretions as detected by RT-PCR. The other infectious markers tested were: bacterial vaginosis and fetal fibronectin in cervical secretions; serum CRP and white blood cell count. RESULTS: The vaginal secretions of 13 of 286 women (4.7%) contained IL-6 mRNA. The only other marker tested significantly associated with IL-6 mRNA+ was the presence of streptococcus in vaginal secretions (30.8% versus 9.4% in the IL-6+ and-groups, p = 0.03). Although the difference did not reach statistical significance (p<0.06 and 0.08, respectively), in women with IL-6 mRNA in cervical secretions we observed a tendency to give birth before 33 and 35 weeks more often than the population as a whole. This group was at higher risk of neonatal infection (38.5% versus 15.1%; p = 0.04). After adjustment for infectious risk factors, IL-6 remained significantly associated with neonatal infection (OR = 4.6, 95% CI [1.1-18.9]). The sensitivity of IL-6 mRNA for neonatal infection was 11.1%. The specificity was 96.7%. CONCLUSION: The detection of IL-6 mRNA by RT-PCR in vaginal secretions allows identification of a small group of women at high risk of neonatal infection, independently of other markers of infection.     

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??Comparison of quality of life between proximal versus total gastrectomy for adenocarcinoma of gastroesophageal junction DAI Bin*, PAN Lin, YANG Chen, et al. *Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
Corresponding author: HU Jian-kun, E-mail: hujkwch@126.com
Abstract Objective To compare quality of life (QLQ) after proximal gastrectomy (PG) or total gastrectomy (TG) for adenocarcinoma of gastroesophageal junction (AEG) (Siewert type II/III). Methods Siewert type II/III AEG cases performed either PG with esophagogastric anastomosis or TG with Roux-en-Y esophagojejunal reconstruction between January 2006 and December 2009 at West China Hospital of Sichuan University were analyzed retrospectively. Patients were followed up by telephone at six months or more after the surgery and QLQ was assessed by EORTC QLQ-C30 and QLQ-STO22 questionnaires. Results A total of 98 cases were Siewert type II/III AEG with 30 dead and 8 lost to follow up. Data from 40 cases in PG group and 20 in TG group were analyzed. There were no significant differences of baselines between two groups related to sex, age, tumor size, TNM stage (AJCC, 6th version) or hospital stay after surgery. TG group scored better than PG group in global health status without significant difference (P=0.072). PG group reported worse scores than TG group with respect to reflux symptoms, dysphagia, eating restrictions, nausea and vomiting, appetite loss, taste abnormality, social functioning and insomnia (P<0.05). Moreover, TG group scored worse than PG group regarding to dyspnoea (P=0.027). Conclusion Siewert type II/III AEG patients treated by TG have a better QLQ than that of PG, especially on the aspects of reflux controlling and appetite improvement.