动脉支架放置术前白细胞计数与锁骨下动脉支架远期通畅率的观察

Objective To study relationship between preprocedural white blood cell count(WBC) and long-term patency of stent implanted in the subelavian artery.Methods Data of 113 cases with stents implanted in the atherosclerotic SUbclavian arteries in Anzhen Hospital,Beijing during January 2005 to January 2008 were analyzed.Student t-test was used to compare the difierence in WBC count between those with patency and those with stenosis after the procedure and chi-square test was used to compare the difference in stent pateney between those with higher and lower WBC counts.Results There Was significant difference in WBC counts between 102 cases with patency and 11 cases with stenosis of the stents after implantation(t=-5.051.P<0.001).Percentage of patency ofthe stents in 36 cases witll higher WBC count(>7.195×109/L)was significantly higher than that in 77 cases with lower WBC count(≤7.195× 109/L)before the procedure(P=0.001).Among 113 cases with stents implanted,109 cases(96.5%) could keep their stents patent one year after implantation,and 60 cases(89.6%)could keep stents patent three yeats after implantation.Conclusions In addition to those traditional factors associated with long-term patency of stents after their implantation,inereased WBC count alSO associated with stenosis or occlusion of the stents after the procedure.     

下肢动脉缺血性患者假性高压的鉴别及临床意义

Objective To evaluate the diagnosis of and management for pseudo-high blood pressure in patients with lower limb ischemia. Methods From March 2006 to March 2007, 182 cases with lower limb ischemia were admitted, and they were divided into three groups. In group 1 pseudo-high blood pressure did not exist, in group 2, patients had pseudo-high blood pressure with ABI<1.3, in group 3, patients had pseudo-high blood pressure and with ABI≥1.3. ABI and TBI were compared with color Doppler, angiography, MRA and CTA. Results In all those 182 patients, there were 102(56.0%)cases having no pseudo-high blood pressure, and 27.5% with concomitant diabetes. Seventy-two cases(39.6%) had pseudo-high blood pressure (ABI<1.3) with 44.4% having diabetes. Eight cases (4.4%) (ABI≥ 1.3) manifested pseudo-high blood pressure with the ratio concomitant diabetes being 75%. Conclusions In diabetic patients with lower limb's ischemia there is increased ratio of pseudo-high blood pressure.     

Behçet病的临床表现及诊断

我们对28例Behçet病患者的临床资料进行了总结分析．发现葡萄膜炎、复发性口腔溃疡，多形性皮肤病变和生殖器溃疡是常见的临床表现，发生率分别为100%、96.43%、96.43%和53.57%，对这些病变的临床特点进行了讨论，指出葡萄膜炎有很高的致盲率，正确的诊断有带赖于对眼部病变和眼外病变的正确认识。 （中华眼底病杂志，1994，10：133-137）     

Cognitive impairment in multiple cerebral infarction.

The cognitive status and related factors in 240 cases of multiple cerebral infarction who were diagnosed by CT scan and cllected successively from 1991 to 1992.     

PI3K蛋白在食管鳞癌中的表达与临床意义

目的 检测PI3K在食管鳞癌及正常食管中的表达情况,探讨其临床意义。方法 采用免疫组化的方法检测56例食管癌组织及20例正常食管组织中PI3K基因的表达,分析肿瘤组织中的PI3K表达与临床病理特征的关系。结果 PI3K蛋白在食管鳞癌组织中的阳性表达率为78.6%(44/56),在正常食管组织的阳性表达率为15.0%(3/20),差异有统计学意义(P<0.05)。结论 PI3K表达与食管癌发生发展及侵袭转移有关,可作为评价食管鳞癌生物学行为的指标。     

颞叶癫(癎)后认知功能障碍与海马萎缩的相关性

目的 比较颞叶癫(癎)患者与健康者认知障碍、海马萎缩的差异,探讨颞叶癫(癎)患者认知障碍与海马萎缩的相关性.方法 随机选取颞叶癫(癎)患者49例和健康对照者20名,神经心理量表评价其认知状态并测量双侧海马体积.结果 与健康者相比,颞叶癫(癎)患者的记忆商(83.2±21.0)和智商(91.0±12.3)显著下降(t=-3.365,-4.291,P=0.001,0.000),双侧海马显著萎缩(P=0.000),不对称指数显著增高(t=3.975,P=0.000),差异有统计学意义.颞叶癫(癎)患者记忆力与癫(癎)病程显著负相关(r=-0.339,P=0-017),左右两侧海马萎缩程度与认知指数均显著负相关(左侧:r=-0.297,P=0.038;右侧:r=-0.305,P=0.033),不对称指数与认知指数显著负相关(r=-0.441,P=0.002).结论 颞叶癫(癎)患者双侧海马的萎缩程度越高、对称性越差,认知损伤也就越显著.海马体积测量可以作为颞叶癫(癎)患者智力下降的评价因子.     

区域献血不良反应监测体系建立与效果评价

目的建立区域性献血不良反应监测体系并评价其运行效果。方法成立区域献血不良反应监测工作组,分2个阶段(2019年1~6月和7~12月)建立和完善献血不良反应监测体系。通过对比分析2个阶段不良反应分类和严重程度分级准确率、单位报告及时率和不良反应各要素的报告率评价区域性监测体系的监测标准的适用性、报告途径的适用性和监测体系运行效果,通过2个阶段报告的献血不良反应发生率和各类不良反应例数分析监测效果。结果第1阶段和第2阶段,各有7家和17家采供血机构加入了区域工作组。第1阶段报告献血不良反应565例,献血不良反应分类准确率为72.04%(407/565),报告及时率为80.95%(34/42),献血者性别、献血类型、献血地点、献血组织方式以及献血不良反应表现、类型、严重程度分级和相关性等要素报告率达到99%以上;献血不良反应处置等相关信息报告率低于20%。第2阶段报告献血不良反应1098例,分类准确率为94.54%(1 038/1 098),报告及时率为96.08%(98/102),献血者性别、献血类型、献血地点、献血组织方式以及献血不良反应表现、类型、严重程度分级和相关性等要素报告率达97%以上;献血不良反应处置等相关要素报告率有所提高,但报告率仍然低于30%,献血不良反应回访相关要素报告率低于20%。报告献血不良反应总发生率为0.87%,第2阶段报告献血不良反应发生率为0.93%(1 098/118 565),高于第1阶段的0.77%(565/73 267),差异有统计学意义(P<0.01)。结论通过两阶段的发展,基本建立了重庆市区域性献血不良反应监测体系。《血液安全监测指南》(T/CSBT 001-2019)作为监测标准和"血液安全监测管理信息系统"作为报告途径适用于本区域监测体系,报告要素需要进行分级管理。     

中药材锁阳的ITS2条形码分子鉴定研究

目的：应用DNA条形码技术准确、快速鉴定中药材锁阳及其混伪品。方法：采用试剂盒法提取药材的基因组DNA,PCR扩增其核糖体DNA的内转录间隔区（internal transcribed spacer 2,ITS2）并进行双向测序,应用CodonCode Aligner V 3.7.1对测序峰图进行校对拼接,比较ITS2序列的GC含量,采用MEGA 5.0计算种内、种间 Kimura 2-parameter（K2P）遗传距离,通过中药材DNA条形码鉴定系统比对和构建NJ 系统聚类树进行鉴定分析。结果：锁阳药材的ITS2序列长度为229 bp,种内变异较小,平均K2P遗传距离为0.003,锁阳药材及其混伪品的种间平均K2P遗传距离为0.760,种间最小K2P遗传距离明显大于锁阳种内的最大K2P遗传距离。中药材DNA条形码鉴定系统比对和NJ树鉴定结果均表明ITS2 序列可区分锁阳及其混伪品。结论：ITS2条形码可有效鉴定中药材锁阳及其混伪品,且具有较好的稳定性和准确性,为保障临床安全用药提供了新的技术手段。     

彩色多普勒超声诊断下肢交通支静脉功能不全的临床价值

目的:研究彩色多普勒超声诊断下肢交通支静脉功能不全的临床价值。方法:回顾性分析行大隐静脉高位结扎加剥脱术、交通支静脉离断术的64例患者(82条肢体)的临床资料。术前应用彩色多普勒超声检出功能不全的交通支静脉并将其定位,与手术结果相对比。结果:与手术结果相比,彩色多普勒超声诊断准确率、敏感性、特异性、漏诊率、误诊率、约登指数、比数积、阳性预测值、阴性预测值及Kappa值为分别是95.8%、96.5%、88.2%、3.5%、11.8%、0.837、206.5、98.8%、71.4%及0.766。由于彩色多普勒超声的Kappa值为0.766>0.75,且(P<0.0001),说明其与手术结果非常吻合。结论:彩色多普勒超声能够准确诊断并定位功能不全的交通支静脉,为诊断和治疗提供重要的依据,具有很高的临床价值。