抑郁发作自杀未遂患者脑源性神经营养因子水平及其相关因素研究

Objective To investigate the possible role of brain-derived neurotrophic factor(BDNF)in the pathophysiology of attempted suicide in depressive episode patients.Methods The subjects were 23 depressive episode patients who had recently attempted suicide.24 depressive episode patients without suicide attempt.and 30 sex-age-and education matched healthy controls.The Hamihon Depression Rating Scale-24 items(HAMD24),Beck Helpless Rating Scale(BHS)and Self-rating Idea of Suicide Scale (SIOSS)was used to evaluate the severitv of symptoms.The seruln level of BDNF was detected with sandwich ELISA.Pearson correlation coefficients wag used to measure the correlations between serum BDNF and the related illness variables.Results There were significant difierences in the serum level of BDNF between patients with attempted suicide,pailents without suicide attempt and normal controls(F=21.927,P＜0.05).Post hoc analysis showed the serum BDNF levels in patients with attempted suicide [(57 ±16)ng/L]were lower than that in patients without[(75±28)ns/L;P＜0.05],and were lower in patients without suicide attempt[(75 ±28)ng/L]than that in normal controls[(111 ±39)ng/L;P＜0.01].In patients with attempted suicide,the serum BDNF was negatively correlated to the duration of depressive episode(r=-0.541,P=0.008),the mean BHS score(r=-0.494,P=0.017)and the mean SIOSSscore(r=-0.754.P=0.000).Conclusion The results suggest that the decreased serum brain-derived neurotrophic factor is related to the pathophysiology of attempted suicide in depressive episode patients.     

影响农村妇女健康的主要因素及对策探讨

妇女，无论是在中国近代史还是社会主义现代化建设中，都以其坚韧的毅力及突出的聪明才智做出巨大贡献，发挥着“半边天”的作用。妇女工作，是妇幼保健工作中的一个重要环节，她也直接关系到下一代的健康成长。1995年，《母婴保健法》地顺利实施，把维护妇女的健康和权益上升到法律的角     

宫颈癌疫苗试验取得可喜结果

如果人类试验能取得与动物试验相同的好结果,可能在3年内获得一种抗宫颈癌疫苗。英国Glasgow大学研究人员研制出一种增强免疫系统以杀伤癌前期肿瘤的疫苗。在有限的试验中发现,此种疫苗能治愈牛肿瘤,这是类似于妇女患宫颈癌之前的肿瘤。     

举办空气粉尘中游离SiO_2红外测定技术短训班

北京医科大学公共卫生学院于1987年1月12日至22日举办第二期空气粉尘中游离SiO_2红外测定技术短训班,参加学习的学员均为各省市有关专业单位派出之具有丰富检验经验的检验师水平者。学习班着重介绍红     

超声宽景成像对浅表器官病变诊断的价值

笔者对30例浅表器官不同疾病患者宽景成像的特点进行分析，并与普通二维超声图像作对比研究。     

医院系统工程的主要框架初线探讨

系统工程是关于现代组织管理的一门学问。系统工程是它所需要控制的对象看作是一个系统，运用系统的观点，以控制论、信息论、概率论为其方法论基础，并以电子计算机为运算手段，对系统实施管理，为此，本文作者把医院看作是一个系统，就如何建立和管好医院系统工程的主要框架作一些初线探讨。     

1995～2000年参加全国微生物室间质评活动分析

目的 就我室1995－2000年参加全国微生物室间质评活动进行总结分析，以利于进一步提高我室微生物检验的总体水平。方法 对卫生部临检中心发放的质控菌株按其要求进行分离检测，对我室结果进行分析。结果 1995－2000年我室接收质控菌75株，9株菌未转种成功，鉴定正确 61株，误检菌5株。结论 我室对革兰阳性球菌、非发酵菌、革兰阳性杆菌、革兰阴性球菌鉴定正确率较高。但应加强对培养基质量的控制，以提高对荷养菌的分离和鉴定率。     

水泥型羟基磷灰石人工骨的制备及性能分析

Objective: To prepare hydroxyapatite cement (or calcium phosphate cement,CPC) and analyze its capability. Methods: Tetracalcium phospluge (TTCP ) was prepared by the method of high heat. TTCP reacted with in simulated body situation and produced CPC. Its capability was analyzed by scanning electron microscopy ( SEM), X-ray diffraction( XRD). Its density, absorbing water coefficient, macroporosity and compressive strength were measured also. Results: The main element of CPC is hydroxyapatile (HA), its microstructure comprised of petal crys-tals. The diameter of micropore was 4-10μm, density was 1. 922 g/cm^3, macroporosity was 29. 777%, absorbing coefficient was 15. 503%, compressive strength was 42.70 Mpa. Conclusion: This CPC has three-dimensional spatial structure, its strength meets the need of cancellous bone grafting.     

水泥型羟基磷灰石人工骨的制备及性能分析(英文)

目的:制备水泥型羟基磷灰石人工骨,并进行性能分析。方法:高温法制备出磷酸四钙,然后在模拟体内环境下将其与无水磷酸氢钙发生水化固化反应,合成水泥型羟基磷灰石人工骨,采用X线衍射、扫描电镜观察、体积密度、吸水率、孔隙率及耐压强度测量进行性能分析。结果:该人工骨主要成分为低结晶度的羟基磷灰石;微观结构呈针状或花瓣状晶体构成,微孔直径约4-10 μm,孔隙相互交通;平均体积密度为1.922 g·cm~(-3);平均吸水率为15.503％;孔隙率为29.777％;耐压强度为42.70 MPa。结论:本研究所制人工骨具有三维空间结构,力学性能符合人体非负重骨植骨要求。