重症臀肌挛缩症治疗效果的相关因素分析

目的:认识重症臀肌挛缩症的特殊性和综合治疗的重要性,并分析影响其疗效的相关因素.方法:根据自定的臀肌挛缩症的分度方法和重症诊断标准,确诊的318例重症患者采用手术及术后功能锻炼结合物理因子治疗,并随访其疗效.结果:本组病例随访3～18个月,有效率100%,治愈率93.8%,并发症少,无复发.结论:手术彻底松解挛缩组织、术后结合有效的功能锻炼和物理因子的治疗、综合考虑多种影响因素,可以明显提高重症臀肌挛缩症治疗的有效率和治愈率,减少术后并发症,有利于该类患者康复和恢复对生活的信心.     

复方麝香注射液联合脑血肿引流术治疗中老年高血压脑出血疗效观察及费用对比

目的:探讨复方麝香注射液联合微创手术治疗中老年高血压脑出血的临床疗效.方法:将78例接受微创治疗的患者随机分组,两组均采用内科综合治疗.手术对照组在综合治疗基础上加用微创手术进行脑血肿引流;中西医结合组在微创手术治疗后加用复方麝香注射液(10～20 ml/d)静脉滴注1周.结果:中西医结合组显效率(66.67%)、有效率(82.05%)均明显高于手术对照组(46.15%和69.23%,P均<0.05),存活患者日常生活能力也明显优于手术对照组(P<0.05),意识恢复时间明显短于手术对照组(P<0.05),并发症的发生率(15.38%)明显低于手术对照组(38.46%,P<0.01),病死率(5.13%)明显低于手术对照组(10.26%,P<0.01),平均住院天数[(18.29±4.93)d]明显少于手术对照组[(26.23±5.82)d,P<0.05],平均住院费用[(5 916.23±826.39)元]明显少于手术对照组[(8 168.35±1 021.21)元,P<0.05].结论:脑血肿引流术后加用复方麝香注射液治疗中老年高血压脑出血,可降低病死率,减少并发症,降低病残程度,提高生存患者的生活质量,缩短住院时间,降低治疗费用.     

法莫替丁与H1受体拮抗剂联合治疗慢性荨麻疹124例疗效观察

124例单用H1受体拮抗剂治疗疗效差的慢性荨麻疹患，联合应用法莫替丁治疗4周，结果显示临床痊愈率和显效分别为85．4％和10．5％，表明法莫替丁与H1受体拮抗剂联合用于这类H1受体拮抗剂不能奏效的慢性荨麻疹患是一种有效的治疗方法。     

毛绞股蓝化学成分研究（Ⅰ）

从毛绞股蓝「Ｇｙｍａｓｔｅｍｍａ ｐｕｂｅｓｃｅｎｓ （Ｇａｇｎｅｐ．）Ｃ．Ｙ．Ｗｕ」全草的水提取物中分离到４个化合物，鉴定其中３个为：（１）ａ－菠甾醇（ａ－ｓｐｉｎａｓｔｅｒｏｌ），（２）商际黄素（ｏｍｂｕｉｎ），（３）邻苯二酚（ｐｙｒｏｃａｔｅｃｈｏｌ）。化合物（４）为一新结构达玛烷型皂甙，结构正在鉴定。     

Differentiation of human epidermal stem cells into fibroblasts induced by TGF-β1 in vitro

Objective To investigate the correlation between human epidermal stem cell (hESCs) and hypertrophic scar or keloid. Methods Improved collagen Ⅳ-coated adhesion methods was used to isolate and culture the epidermal stem cells after neutral protease selectively digested the dermo-epidermal junctions. After the cells were cultured and expanded in vitro, and passage 3 hESCs were induced by different concentrations of TGF-β1 (0.1, 5.0, and 10.0 ng/ml). Morphological fea-tures and identification of these cells were meseasured by HE, Masson, immunohistochemical staining on the days 3 and 7, respectively. Results After induced by TGF-β1 for 3 and 7 days, the morpholo-gy of the epidermal stem cell (hESCs) was changed into fusiform shape, similar to fibroblasts. 70 % ofthe cell which was induced by TGF-β1 were blue stained in the cytoplasm by Masson stain, which is the distinctive method for collagen, suggesting collagen appeared or increased in the cells. The collagen concentrations in supernatants of hESCs were 0.4150±0.0014, 0.3380±0. 0020, and 0.3870±0.0020, much higher than that in control group (0.0780±0.0025) and normal skin fibro-blast group (0.15004±0.0051) (P<0.05). Immunohistochemical staining revealed that positive rates of these cells for anti-vimentin staining were more than (95.00±1.20)% in experiments and (5.70±0.20)% in control group. Conclusion The differentiantion of hESCs induced by TGF-β1 into fibro-blasts indicates that hESCs may play a role in the pathogenesis of hypetrophic scar and keloid.     

钢丝针芯支架行输精管吻合术95例临床观察

钢丝针芯支架行输精管吻合术９５例临床观察王久义１徐传淑２杜东岭１我院应用钢丝针芯作输精管腔内支架行输精管吻合术，效果良好，现报告如下。１临床资料１．１一般资料９５例病人平均年龄３３．９６岁，其中２４～３０岁１６例，３１～４０岁７１例，４１～５０岁８例...     

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进1例

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进１例大连医科大学附属第二医院肾内科（１１６０２３）尹永红麻军患者男，４２岁。以多饮、多尿２年，恶心、呕吐３个月为主诉入院。２年前出现烦渴、多饮，每日饮水量７５００～１００００ｍｌ，多尿、夜尿增多。未介意。...     

中西医结合治疗坏死性筋膜炎

本文积累了１９８１～１９９４年近十余年的临床资料，总结了中西医结合治疗坏死性筋膜炎的临床治疗经验。指出坏死性筋膜炎是一种少见的严重的软组织感染，发展迅速，病死率高，应引起临床医生的高度警惕，做出早期诊断是非常必要的。提出了扶正祛邪的中西医结合的整体治疗方案，全身治疗与局部处理相结合。对患处要采取早期，这时的多切口引流，给＂邪＂以出路。取得良好的疗效。