不同门奇断流术式对门静脉高压症犬食管下段血管再生的影响

Objective To explore the effect on blood vessel regeneration of distal esophagus in ca-nines of portal hypertension with liver cirrhosis after different procedures with paraesophagastrie devascular-ization. Methods Portal hypertension models were produced in canines by subcutaneous injection of 60% CC14 combined with food restriction. Forty eight model canines were randomly divided into 4 groups: group A, traditional paraesophagastrie devascularization;group B, selective paraesophagastric devascularization;group C, paraesophagastric devascularization plus distal esophageal transaction and reanastomosis with sta-pler;group D,control group. Every group had 12 canines which were randomly divided into A1 ,B1 ,C1 ,D1, A2,B2,C2 and D2 groups after the operation. Canines in groups A1 ,B1 ,C1 and D1 were executed at first month after the operation,and those in groups A2, B2, C2 and D2 were executed at the 6th month after the operation. The distal esophagus was segmented when the canines were executed. The upside and downside of the stoma in group C were distinguished and signed as Ca and Cb. Immunohistochemieal methods were used to detect VEGF,CD34 and FVⅧ-Rag,blood vessel-related factors,in lower esophagus. Results The expres-sion levels of VEGF and CD34 MVD,FⅧ-Rag MVD in groups A1 ,B1 and C1 were lower than those in group D1 one month after the operation (P <0.05). All the indices in group B1 were lower than those in groups A1 and Clb,but higher than those in group Cla (P <0.05). The indices in group Cla were lower than those in group C1b (P < 0.05 ). The indices in groups A2 and B2 were higher than those in groups A1 and B1, re-spectively at the 6th month after the operation (P <0.05). They were higer in outer membrane in group C1a than in group C2a (P <0.05). The indices in group C2b were higher than those in group Clb (P<0.05). Conclusion At the first month after operation, the expression of blood vessel-related factors was declined in three different procedures of paraesophagastric devascularization,which indicated that all three different pro-cedures could diminish the vessels in distal esophagus. The effect in group C was most obvious among all groups. At the 6th month after traditional paraesophagastrie devascularization and selective paraesophagastrie devascularization, the expression of blood vessel-related factors in distal esophagus was declined. But there were no significant changes in the expression of blood vessel-related factors in distal esophagus after parae-sophagastric devascularization plus distal esophageal transaction and reanastomosis with stapler. It indicated that the blood vessel regeneration in paraesophagastric devascularization pins distal esophageal transaction and reanastomosis with stapler was inferior to that in other procedures.     

山丘型地区消灭血吸虫病后彻底灭螺价值的探讨

消灭钉螺的目的是为了消灭血吸虫病。但是,已经消灭血吸虫病的地区,是否还要彻底灭螺,这是当前防治血吸虫病工作中迫切需要解决的重要课题。消灭血吸虫病标准规定:“在流行地区范围内,需要连续三年查不到钉螺”才算消灭,因此,不少地区虽然早已消灭血吸虫病,仍然对残存钉螺或已经无螺但环境仍然适合钉螺孳生的广大地区,全面开展预防性的药物灭螺,不但造成药物的严重浪费,而且污染环境,破坏生态平衡,这种作法是否还要坚持下去,值得慎重考虑。为了探讨防     

肝外伤后胆道周期性出血3例报告

1 引言肝外伤后胆道周期性出血是由于创伤引起肝内血管与胆管的病理性沟通的结果。血液通过肝内肝外胆道,进入十二指肠而引起消化道出血,以便血为主。我院1978年5月～1985年6月共收治3例,报告如下。     

派罗欣治疗慢性乙型病毒性肝炎的观察与护理

目的探讨乳腺癌术后胸部气压固定带的制作及临床应用价值。方法将64例乳腺癌术后患者随机分为观察组和对照组各32例,对照组采用传统的绷带加压包扎,观察组采用自行设计并制作的胸部气压固定带加压包扎。观察两组术后引流量、拔管时间及并发症的发生情况。结果观察组皮下积液发生率显著低于对照组（P〈0.05）,术后24h引流量、置管时间显著少于/短于对照组（均P〈0.01）。结论乳腺癌术后使用胸部气压固定带加压固定可减少渗出,缩短置管时间,降低皮下积液发生率。     

血液流变学检测在几种老年病防治中的价值

我国人口组成老龄化已呈明显上升趋势。老年人的发病率高达92．5％。老年疾病和血液流变学的改变密切相关，从血液流变学角度着手，对老年疾病进行防治研究，是一个重要课题。     

运动中猝死

所谓猝死是指发病24小时内不可预见的死亡，不包括交通事故等外伤性死亡。在运动中40岁-59岁练剑术的人相对危险率最高，其次为滑雪，登山和棒球，高尔夫及游泳比跑步的相对危险率低。60岁以上的人打高尔夫球和登山的危险率要有所增高，其它的运动项目同40岁-9岁赛跑的人的危险率相同。30岁以下的年轻人运动中猝死的疾病主要是肥大型心肌病。     

肝切除术后膈下感染临床分析

肝切除术后并发症较多 ,膈下积液感染是常见的并发症之一。随着肝脏外科的发展和围手术期处理的加强 ,这一并发症在逐渐减少 ,但在一些基层医院 ,由于各种原因 ,膈下感染发生率仍较高 ,甚至危及病人生命。现将我院近 15年来资料完整的肝切除术 2 6 2例出现膈下感染 2 2例分析如下。1　资料与方法2 6 2例肝切除术中男性 12 5例 ,女性 137例 ,年龄在 6～ 6 5岁。其中因肝胆管结石需行肝切除术 180例 ,原发性肝癌行肝切除术 6 2例 ,严重肝外伤行不规则肝切除术 2 0例。合并肝硬化 35例 ,糖尿病 (2型 ) 17例。肝胆管结石病人有 1次以上手术史占 …     

药物构效关系研究与药物设计中常用计算机软件

分子力学、量子化学和分子图形学是研究有机药物分子电子特性、空间性质及其与受体相互作用的有力工具。现扼要介绍国内外较常用的量子化学和分子力学及分子图形学有关计算机程序的应用特性。