乙肝病毒携带孕妇羊膜腔穿刺术后宫内传播的风险研究

目的探讨乙肝病毒携带孕妇羊膜腔穿刺术后宫内传播的风险。方法对本院有侵入性产前诊断指征，无肝功能明显异常的33例乙肝病毒携带孕妇行羊膜腔穿刺术，分另q对其出生后24h内及1月龄婴儿的乙肝病毒血清学标志物检测结果进行随访。结果33例接受羊膜腔穿刺术的乙肝病毒携带孕妇，除1例乙肝表面抗原阳性患者因胎儿为21三体引产，2例患者拒绝随访外，余30例均妊娠至足月分娩，出生后24h内及1月龄婴儿无一例HBsAg阳性。宫内感染率的95％可信区间为0％～12％。结论乙肝病毒携带孕妇羊膜腔穿刺术后宫内传播的风险较低。     

贝伐单抗联合放射方案的实验研究

Objective To evaluate the impact of the hypoxia induced by bevacizumab on the antitumor effect in combining with irradiation in CNI-H441 xenografts in mice. Methods Bevacizumab of 5 mg/kg mouse for groups of control, bevacizumab alone, irradiation alone, earlier combination (EC), and later combination (LC) were initially injected peritoneally. Single irradiation of 14 Gy (122Sc γ-ray) was given at the 4th hour for the group of irradiation alone, 24th hour for EC group, and 72nd hour for LC group after the initial injection. Tumor hypoxia, micro vessels density and permeability of tumor vasculature,pathological responses, apoptosis, and tumor growth delay curve were evaluated after using bevacizumab and/or irradiation. Results Although it was lower than the control at the 24 hr after using bevacizumab (3. 1 × 106: 6.1 × 106 ;t = - 1.73 ,P > 0. 05), the HIF-1α rapidly increased to 3 - 4 times and 2 - 3 times of the control at day 3 (7.4 × 106: 20. 4 × 106; t = 2. 36, P < 0. 05) and lasted until day 10, which was consistent with the changes of tumor function vessels count. The count of residual micro vessel density count in LC group was higher than that in groups of EC and irradiation at day 3 after irradiation (9. 33: 3. 17;t =- 2. 43, P < 0. 05). The apoptotic count of tumor cells was lower in LC group than that in EC group (23.33: 43.83; t= 2.54, P< 0.05, at day 3 after radiation). Tumor growth delay time of LC groupwas shorter than that of EC groups (10. 5 days vs. 23. 0 days , t = 2. 67 , P < 0. 05) . Conclusions Hypoxia level induced by bevacizumab decreases the antitumor effect in later combination of bevacizumab and irradiaion. It shows a time window that determines whether the combination of bevacizumab and irradiation will be benefit or diverse.     

中药复方制剂工艺研究问题、模式与策略

中药复方是中医临床用药的主要形式和手段,在保障中药复方制剂安全、有效、稳定、可控的基础上,合理设计中药复方制剂的工艺路线、生产装备和质量控制方法,建立一套符合中药复方制剂特点的工艺研究模式尤为重要。基于中药复方制剂的政策、工艺、装备现状,运用整体观、动态观和辨证观分析中药复方制剂的工艺模式,突破中药复方制剂的研究难点,提出中药复方制剂工艺开发的研究策略,以期为中药复方制剂工艺研究提供参考。     

综合治疗儿童弱视154例疗效分析

目的观察综合治疗弱视的效果。方法对154例（216眼）弱视患儿进行综合治疗结果分析。结果3～（岁）治愈率88．63％，6～（岁）78．79％，9～12岁34．48％；轻度弱视治愈率100％，中度弱视治愈率77．45％，重度弱视治愈率15．62％，总有效率94.91％。结论年龄越小疗效越好，弱视程度越轻治愈率越高。弱视应早发现早综合治疗。     

宫腔镜检查在异常子宫出血期间应用的安全性分析

目的探讨宫腔镜检查在异常子宫出血(AUB)期间应用的安全性。方法将100例AUB患者随机分为观察组和对照组各50例。观察组于异常子宫出血量较少时行宫腔镜检查;对照组于月经干净3～7d后行宫腔镜检查,观察2组术后0.5h出血量、并发症及术后1周感染情况。结果 2组均顺利完成宫腔镜检查,观察组同时行刮宫术15例(30.0%),对照组同时行刮宫术16例(32.0%),差异无统计学意义(P>0.05);2组术后0.5h出血量差异无统计学意义(P>0.05);2组术中均未出现并发症,且术后1周均未发生感染。结论严格无菌手术操作,在AUB出血未止时进行宫腔镜检查,不增加术中并发症的发生率,且不增加术后感染几率,值得临床推广应用。     

产后尿潴留的护理

尿潴留是指尿液在膀胱内积聚不能排出.产后尿潴留多见于初产妇及第二产程延长的产妇.急性尿潴留,膀胱极度扩张,如能及时处理,可以恢复功能.若拖延过长,则膀胱肌肉将失去收缩的能力形成无张力膀胱,很难恢复功能,给产妇造成极大的痛苦.当膀胱充盈时就会通过神经反射到大脑,膀胱肌肉收缩,尿道括约肌松弛,尿液由膀胱经尿道排出体外.一般产后4～6h内能自己排尿,若产后6h以上仍不能自动排尿,且膀胱满称产后尿潴留,它是产科常见并发症之一,不仅影响子宫收缩,导致阴道流血量增加,而且给产妇增加痛苦,也是造成泌尿系统感染的重要因素.     

光动力疗法治疗92例尖锐湿疣效果分析

目的 分析盐酸氨酮戊酸光动力治疗尖锐湿疣的疗效和安全性. 方法 92例尖锐湿疣患者,外搽盐酸氨酮戊酸溶液3 h后,用氦-氖激光照射20 min,能量密度100 J/cm2. 结果 92例患者经过1～5次治疗,均达到完全缓解.在随访的三个月内,有9例患者复发,复发率为9.8%.治疗后无一例患者有瘢痕形成. 结论盐酸氨酮戊酸光动力治疗尖锐湿疣疗效好、安全性高、复发率低.