同种带瓣主动脉移植治疗矫正性大动脉转位的术后护理

总结应用同种带瓣主动脉移植治疗２４例矫正性大动脉转位的护理经验。本组病人均合并有其它心内畸形，传导束走行具有特殊性。术后应加强对心律变化的观察及起搏导线的护在植入带瓣主动脉，易发生感染和排斥反应，基础护理十分重要；要熟悉矫正性大动脉转位的解剖特点，让病人保持平卧或适宜体位，防止移植的主动脉扭曲、受压；指导病人正确抗凝；如发现移植的主动脉退化要及时处理，必要时再次手术。     

“一站式结算”在医院财务管理中的开发与应用

为实现简化患者就诊结算服务流程,有效缩短病人就医结算的等待时间的目标,开发"一站式结算"并应用于医院财务管理中,通过充分利用现代信息技术的手段,为患者提供更优质便捷的服务。     

慢性硬膜下血肿术后并发急性颅脑外伤一例

目的慢性硬膜下血肿术后并发急性颅脑外伤治疗经验。方法对1例慢性硬膜下血肿术后并发急性颅脑外伤病例临床表现,影像学资料,治疗方法分析。结果慢性硬膜下血肿术后可出现癫痫发作,并引起急性颅脑损伤。结论避免慢性硬膜下血肿术后出现癫痫发作的预防办法及注意事项。     

体外循环术后脑昏迷患者的护理

脑昏迷是体外循环术后严重的并发症之一,致死致残率极高.我科从1988年1月至1998年12月共施行心内直视手术8613例,发生不同程度脑昏迷34例,占0 39%.现将脑昏迷的发生原因及观察护理经验总结如下.     

S/5 ADU麻醉工作站麻醉药浓度不准或故障提示检修

S/5 ADU麻醉工作站是芬兰国Datex-Ohmeda生产的最高档次的麻醉机,因为其麻醉药剂浓度和新鲜气流量是全电子控制,在临床使用中经常会出现一些新鲜气故障或麻醉药浓度监测误差偏高等问题。我院多年来的维修经验验证,现将具体的详细校正维修步骤描述如下,供大家参考。     

健脾敛溃汤治疗消化性溃疡100例临床观察

我们从2001年7月～2003年7月，用中药健脾敛溃汤治疗消化性溃疡100例，并设对照组90例，取得满意疗效，现总结如下。     

心内直视术后胃肠营养中消化道并发症的护理要点

胃肠道营养（ＥＮ）能够通过生理和免疫的调节，保护肠粘膜结构屏障的完整性，可防止和减轻高代谢，减少胃肠内细菌易位及内毒素的吸收而导致的内源性感染，［１］可避免患者因长期空腹导致的应激性溃疡，是术后不能经口进食的主要营养途径。我科室于１９９５年４月至１９９８年１月施行心内直视术２１８２例，其中１５８例术后因病重不能脱离呼吸机的患者施行ＥＮ，在取得明显营养效果的同时，也发现ＥＮ将导致一些并发症，如恶心呕吐、胃潴留、腹泻等胃肠道反应。现就其原因及护理对策作如下讨论。１　临床资料本组１５８例，男９６例，女…     

蜂胶醇提物对大鼠肝脏线粒体氧自由基损伤的保护作用

目的 研究蜂胶醇的提物对线粒体氧自由基损伤的保护作用. 方法 采用FeSO4/半胱氨酸（Fe^2＋/Cys）体系造成鼠肝脏线粒体损伤模型,测定线粒体肿胀、丙二醛（MDA）、琥珀酸脱氢酶（SDH）.结果 Fe^2＋/Cys损失组与正常对照组比较,线粒体肿胀度和MDA均明显增加,SDH活力明显降低. 结论 蜂胶醇提物可剂量依赖性保护大鼠肝脏线粒体的氧自由基损伤.     

OHMEDA 5250呼吸气体监护仪氧电池故障

Ｏｈｍｅｄａ 5 2 5 0呼吸气体监护仪在经过一段时间使用以后 ,会出现气体检测数据和波形不准确 ,检测吸入氧浓度低 ,出现ＬＯＷＩＮＳＰＩＲＥＤＯ2 报警提示等 ,在进行气体校准时不能通过 ,出现ＩＮ ＶＡＬＩＤＯ2 ＺＥＲＯ或ＩＮＶＡＬＩＤＯ2 ＳＰＡＮ等提示。此时 ,一般是因氧电池已达到使用寿命 ,只要更换新的氧电池后 ,监护仪即可排除故障 ,恢复正常工作。氧电池更换方法如下。1 关闭监护仪电源开关 ,断开监护仪电源。2 按下气体监护仪前面左下角的液晶显示屏释放开关 (Ｄｉｓｐｌａｙｒｅｌｅａｓｅ) ,同时将显示屏向右移 ,取下显…     

Inhibitory Effects of Mild Hyperthermia plus Docetaxel Therapy on ER（＋/-） Breast Cancer Cells and Action Mechanisms

Summary： The purpose of this study was to verify that a combination of mild hyperthermia and do- cetaxel chemotherapy produces synergistic antitumor effects and to explore the action mechanisms of this treatment approach. The effects of docetaxel on the proliferation of cells from the estrogen receptor （ER）-positive human breast cancer cell line MCF-7 and the ER-negative human breast cancer cell line MDA-MB-453 were examined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay, and effective experimental concentrations of docetaxel were determined. The effects of mild hy- perthermia plus docetaxel therapy on apoptosis rate in the MCF-7 and MDA-MB-453 human breast cancer cell lines were analyzed by using flow cytometry with Annexin-V fluorescein isothiocyanate （FITC）/propidium iodide （PI） staining. The effects of these combined treatments on cell cycle progres- sion in the MCF-7 and MDA-MB-453 human breast cancer cell lines were examined by using flow cy- tometry. The effects of these combined treatments on the expression of apoptosis-related proteins and proteins in the mitogen-activated protein kinase （MAPK） pathways were analyzed by using Western blotting. The effects of these combined treatments on the expression of the heat shock protein 70 （HSP70） and the multi-drug resistance （MDR） gene product P-glycoprotein （Pgp） were examined by using Western blotting. The results showed that the half-maximal inhibitory concentration （IC50） of do- cetaxel for MCF-7 and MDA-MB-453 cells was 19.57±1.12 and 21.64±2.31 gmol/L respectively. Mild hyperthermia with docetaxel therapy could increase apoptosis rate in the MCF-7 and MDA-MB-453 cells. Apoptosis rate in MCF-7 and MDA-MB-453 cells was increased from （23.66±3.59）% and （18.51±3.17）% in docetaxel treatment group to （47.12±6.73）% and （55.16±7.42）% in mild hyperthermia plus docetaxel group, indicating that the mild hyperthermia and docetaxel therapeutic approaches exhib- ited significant synergistic antitumor effects. Treatments of mild hyperthermia plus docetaxel induced G2/M cell cycle arrest in the MCF-7 and MDA-MB-453 cells. Western blotting demonstrated that pro- teins in the MAPK pathway were expressed at higher levels in docetaxel-treated cells following mild hypothermia than those in cells treated with docetaxel alone. As compared with blank control group, cells from the mild hyperthermia plus docetaxel group exhibited significantly decreased B-cell lym- phoma 2 （Bcl-2） protein expression but slightly increased Bcl-2-associated X protein （Bax） expression. Western blotting results revealed that HSP70 and Pgp expression levels were significantly increased following mild hypothermia. It was concluded that treatments of mild hyperthermia plus docetaxel in- hibited the proliferation of human breast cancer cells, promoted apoptosis of breast cancer cells, and produced synergistic antitumor effects.