《伤寒论》气机升降失调之病机及分类证治

本文通过对《伤寒论》气机升降失调诸证的病因病机、临床表现、辩证治疗、遣方用药的探讨,总结出张仲景对气机升降失调诸证治疗的规律：首先应掌握祛邪扶正与调理气机的关系及各种不同情况下的轻重主次。其次,认为仲景在对气机升降失调诸证的治疗过程中,尤其注重调理脾胃。     

《伤寒论》厥阴四大类证证治研究

《伤寒论》厥阴是六经之末,病情发展到厥阴,即病变已到了后期阶段,病变后期寒热混杂,虚实互见,他经他脏病证亦屡出迭见,这是一个很自然的现象或规律。厥阴篇病情复杂,主要表现是寒热挟杂和厥热胜复,但厥阴篇所述病变证治,重点却是厥、利、呕、哕这四大类证。笔者就此四大类证作了一些探讨,认为四大类证多为他经他脏之病,非厥阴经本病,故称其为"类证"。但对类证证治则作了详尽分析,因为笔者认为这四大类证实际上多为杂病杂证,为临床之所常见,不可必认为是伤寒后期才出现,这是笔者在研读中所谓的阐微之见。     

国医大师何任治疗神志病经验拾零

何任教授系浙江中医药大学主任医师,获首届"国医大师"荣誉称号。何任老师年届九秩,精神颇佳,老当益壮。笔者跟随何任老师临证抄方,并阅读何师的有关医案,发现何师治疗神志病的经验非常丰富,重视经方的运用,强调化痰祛瘀治法,用药平常,获效甚好。     

读《金匮要略校注》后

<正>《金匮要略校注》(以下称《校注》)一书,乃浙江何任先生主编,殷品之、杨百茀、刘渡舟、欧阳锜等专家审定,人民卫生出版社1990年8月出版,为卫生部、国家中医药管理局文献研究课题之一,理应给人读书以启迪,然读后使人感到颇有可商之处,为了中医药学术之发展,特根据"百家争鸣"精神,顺序摘出疑点如下,以与何任先生商     

中医的思维模式，由模糊走向清晰

<正>中医是道术并重的国学,低碳环保的国医。它所以能够做到这一点,与它所依赖的传统文化有关。传统文化的精华,是古人看待世界的方法论、世界观。有了大视野,才能有大智慧。中医认识人体,采用的比较早、比较多的方法是"取象比类"。1以象统数,取象比类相同的研究对象,可以使用不同的研究方法,有的方法可能比较     

Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers

Insulin-like growth factor-bindin g proteins (IGFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IGF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IGFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IGF (IGF-dependent effects) and sometimes not (IGF-independent effects). The functional role of IGFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IGFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IGFBP5 in different types of cancers.     

Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis

AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute appendicitis.METHODS:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study group.Patients were divided into two groups.appendicitis group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed non-operatively.The operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up forms.RESULTS:One hundred and thirteen patients with suspected acute appendicitis were included in the study.Of the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)years.Of the 113patients,94 patients underwent surgery,while the rest were followed non-operatively.Of the 94 patients,77patients were histopathologically diagnosed with acute appendicitis.Our study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was used.CONCLUSION:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis.     

中医发展中一些需要思考的问题

《内经》一书构建了中医学基本理论和框架,其成书过程是和当时的社会科学、自然科学紧密关联的。南于历史原因,当时的社会科学相对比较成熟,而自然科学相对比较简朴,所以形成了中医学的重要特点——哲学、社会学思想引入、使用比较多,同时较模糊,也相对比较抽象。     

科学发展中医的核心是“天地通”

由于人们对什么是科学、中医与科学之关系的认识存在分歧,所以笼统地说"科学发展中医"带有很大的模糊性,应该首先思考几个问题,以便由模糊走向清晰。1坚持大科学观,反对科学主义科学是什么?目前没有一个标准答案,综合各家对"科学"一词的认识,可以说"科学"的基本含义