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51.
Objective To investigate the possibility of inducing immune tolerance to vein trans-plantation in rats by intrathymic injection of allogene. Methods MHC antigen extracted from splenic cells of donor Wistar rats was intrathymically injected to recipients SD rats, and donor Wistar femur vein was transplanted after 2 weeks. Forty-eight SD rats were randomly divided into 4 groups: group A ( femur vein autograft) ,group B ( femur vein allograft) ,group C ( femur vein allograft with use of immunosuppressant), group D (intrathymus injection). Imaging, histology and immunological assays of these groups were carried out 2 weeks after the transplantation. Results Histologic parameters that were tested were better in group D than those in group B. The concentration of serum IFN-γ in group B was significantly higher than that in groups A, C and D [ ( 86. 707±10.928 ) ng/L vs (29.328±4. 170), (69.076±8.059) and (63.355± 4.895) ng/L respectively, P < 0.05 ]. The concentration of serum IL-4 in group B was obviously lower than in groups C and D [ (23.656±3.369) ng/L vs (29.425±4.174) and ( 31.000±4.659) ng/L re-spectively,P < 0.05 ]. Conclusion Intrathymus injection of allogenic antigen might induce specific im-mune tolerance to femur vein transplantation in rats. 相似文献
52.
骨形成因子 (BoneMorphogeneticProtein :BMP)属于生长转移因子 (Transforminggrowthfaltorβ)是属于TGF—β的一种蛋白质 ,在机体内对骨组织具有特异性的诱导活性 ,且是与多种多样细胞的增殖、分化、基质产生等相关的多功能性因子。它在骨形态的形成及机体功能调节等方面具有重要的作用。1 BMP的基础研究BMP自被发现以来 ,国内外许多学者经过 30多年的研究 ,特别是最近的十年间 ,伴随着分子生物学技术的应用 ,已取得了显著成绩。1 1 BMP的组成与种类Urist[3] 将经… 相似文献
53.
Objective To investigate the possibility of inducing immune tolerance to vein trans-plantation in rats by intrathymic injection of allogene. Methods MHC antigen extracted from splenic cells of donor Wistar rats was intrathymically injected to recipients SD rats, and donor Wistar femur vein was transplanted after 2 weeks. Forty-eight SD rats were randomly divided into 4 groups: group A ( femur vein autograft) ,group B ( femur vein allograft) ,group C ( femur vein allograft with use of immunosuppressant), group D (intrathymus injection). Imaging, histology and immunological assays of these groups were carried out 2 weeks after the transplantation. Results Histologic parameters that were tested were better in group D than those in group B. The concentration of serum IFN-γ in group B was significantly higher than that in groups A, C and D [ ( 86. 707±10.928 ) ng/L vs (29.328±4. 170), (69.076±8.059) and (63.355± 4.895) ng/L respectively, P < 0.05 ]. The concentration of serum IL-4 in group B was obviously lower than in groups C and D [ (23.656±3.369) ng/L vs (29.425±4.174) and ( 31.000±4.659) ng/L re-spectively,P < 0.05 ]. Conclusion Intrathymus injection of allogenic antigen might induce specific im-mune tolerance to femur vein transplantation in rats. 相似文献
54.
55.
纳络酮对全脑缺血大鼠的神经保护作用研究 总被引:2,自引:0,他引:2
全脑缺血后如何保护脑功能、减轻缺血/再灌注损伤是目前研究热点,但有效的神经保护剂并不多,仅tempol、MK-801等在实验中证明有效。纳络酮,作为传统意义的阿片受体拮抗剂,在许多实验和临床研究中亦被证明有神经保护作用,但仍存在较多争议。最近研究揭示纳络酮具有抑制钙超载的作用,本文通过研究其对钙结合蛋白表达的影响来探讨纳络酮的神经保护作用。1材料与方法实验选用健康SD大鼠29只,雌雄不拘,体重185.5~294.0g,建立窒息 艾司洛尔的大鼠心肺骤停模型[1],实验参数设计和记录均参照实验研究的Utstein模型。实验动物随机分为4组:假手术组… 相似文献
56.
57.
Objective To investigate the possibility of inducing immune tolerance to vein trans-plantation in rats by intrathymic injection of allogene. Methods MHC antigen extracted from splenic cells of donor Wistar rats was intrathymically injected to recipients SD rats, and donor Wistar femur vein was transplanted after 2 weeks. Forty-eight SD rats were randomly divided into 4 groups: group A ( femur vein autograft) ,group B ( femur vein allograft) ,group C ( femur vein allograft with use of immunosuppressant), group D (intrathymus injection). Imaging, histology and immunological assays of these groups were carried out 2 weeks after the transplantation. Results Histologic parameters that were tested were better in group D than those in group B. The concentration of serum IFN-γ in group B was significantly higher than that in groups A, C and D [ ( 86. 707±10.928 ) ng/L vs (29.328±4. 170), (69.076±8.059) and (63.355± 4.895) ng/L respectively, P < 0.05 ]. The concentration of serum IL-4 in group B was obviously lower than in groups C and D [ (23.656±3.369) ng/L vs (29.425±4.174) and ( 31.000±4.659) ng/L re-spectively,P < 0.05 ]. Conclusion Intrathymus injection of allogenic antigen might induce specific im-mune tolerance to femur vein transplantation in rats. 相似文献
58.
59.
应用离断指骨、神经急诊一期手指再造 总被引:2,自引:0,他引:2
目的:介绍应用离断指骨、神经急诊手指再造的临床效果。方法:对14例15指手指毁损性离断者,急诊采用离断的指骨、神经再造手指。结果:再造的手指全部成活。术后随诊1年~4年,再造手指血运丰富,外形满意,均恢复痛、温、触等保护性感觉。患手恢复了捏夹、抓握等基本功能。结论:急诊应用离断的指骨、神经再造手指对恢复手的功能有效。 相似文献
60.
关于急诊管理模式及急救复合人材培养的建议 总被引:8,自引:2,他引:6
医院急诊作为急诊医学体系的重要组成部分和急诊医学事业发展的主要功能组织 ,正在医学领域中发挥着不可低估的积极作用。但是 ,目前许多医院 ,尤其是一些业务繁忙的大型综合性医院急诊室仍存在着脏、乱、差、忙的局面 ,而且有些医院的矛盾还十分突出。急诊科承受的压力越来越重 ,一些不治之症及晚期肿瘤病员都滞留在急诊室 ,使现有的急诊科牵扯精力过大 ,无法考虑如何进一步做好危重病人 ,尤其是那些突发危及生命疾病的救治工作。社会不满意 ,病人不满意 ,急诊室工作人员也不满意。领导更是因纠纷投诉多当起了“救护队员”。以上状况究其根… 相似文献