青少年第三腰椎横突综合征43例诊治分析

目的分析青少年第三腰椎横突综合征的临床诊治特点。方法观察2007～2009年来解放军474医院门诊诊治的第三腰椎横突综合征青少年,症状和体征是诊断的重点。结果手法治疗均可取得良好效果,43例患者,38例治愈（88.4%）,5例有效（11.6%）,总有效率为100%。结论青少年第三腰椎横突综合征常见,手法治疗应首选,改变学习、生活习惯是预防的关键。     

胸腺修饰诱导同种异体静脉移植的免疫耐受研究

目的 观察大鼠胸腺内注射异基因抗原在同种异体异基因股静脉移植免疫耐受中的作用.方法 将48只SD大鼠随机分为4组:自体股静脉移植组(A组)、异体股静脉移植组(B组)、异体股静脉移植免疫抑制剂组(C组)、胸腺内注射供体组织相容性(MHC)抗原后移植组(D组).于2周后进行影像学、组织学、免疫学检测.结果 组织学检测结果显示:D组、C组急性排斥反应损伤较轻,B组血管壁的各层结构破坏最重,可见大量炎性细胞浸润.B组受体大鼠血清干扰素(IFN)-γ浓度为(86.707±10.928)ng/L,显著高于A、C、D组[(29.328±4.170)、(69.076±8.059)、(63.355±4.895)ng/L,P<0.05];B组受体大鼠血清白细胞介素(IL)-4浓度为(23.656±3.369)ng/L,显著低于C、D组[(29.425±4.174)、(31.000±4.659)ng/L,P<0.05].结论 胸腺内注射异基因MHC抗原可诱导大鼠对同种异体血管移植的特异性免疫耐受.     

手外伤修复中真皮下血管网皮瓣的应用研究

目的探讨真皮下血管网皮瓣修复手外伤创面的手术方法及效果。方法2004年10月～2008年10月,应用胸、腹部带蒂真皮下血管网皮瓣修复手部皮肤软组织缺损创面45例。结果术后43例皮瓣完全成活,仅2例皮瓣远端小部分皮肤坏死,经换药后愈合。术后随访6个月～3年,伤手受区皮肤外形美观、色泽好,功能恢复满意。结论应用胸腹部带蒂真皮下血管网皮瓣修复手部皮肤软组织缺损是一种较理想的修复方法。     

中医诊疗过程中复杂问题的决策流程初探

中医传统诊疗决策理论的形成和发展模式,多是以医生个体经验的提升为基点,延伸为不同学术流派理论体系的形成.群体决策经验由于受到科学技术发展水平的影响,表现出一定的滞后性和非即时性,分散存在于历代医学著作中.综合集成法为医生个体与群体并重的决策信息转化提供方法论指导,通过发现问题、确定目标、确定价值准则、拟制方案、分析评价...     

胸腺修饰诱导同种异体静脉移植的免疫耐受研究

Objective To investigate the possibility of inducing immune tolerance to vein trans-plantation in rats by intrathymic injection of allogene. Methods MHC antigen extracted from splenic cells of donor Wistar rats was intrathymically injected to recipients SD rats, and donor Wistar femur vein was transplanted after 2 weeks. Forty-eight SD rats were randomly divided into 4 groups: group A ( femur vein autograft) ,group B ( femur vein allograft) ,group C ( femur vein allograft with use of immunosuppressant), group D (intrathymus injection). Imaging, histology and immunological assays of these groups were carried out 2 weeks after the transplantation. Results Histologic parameters that were tested were better in group D than those in group B. The concentration of serum IFN-γ in group B was significantly higher than that in groups A, C and D [ ( 86. 707±10.928 ) ng/L vs (29.328±4. 170), (69.076±8.059) and (63.355± 4.895) ng/L respectively, P < 0.05 ]. The concentration of serum IL-4 in group B was obviously lower than in groups C and D [ (23.656±3.369) ng/L vs (29.425±4.174) and ( 31.000±4.659) ng/L re-spectively,P < 0.05 ]. Conclusion Intrathymus injection of allogenic antigen might induce specific im-mune tolerance to femur vein transplantation in rats.     

骨形成因子的研究进展

骨形成因子 (ＢｏｎｅＭｏｒｐｈｏｇｅｎｅｔｉｃＰｒｏｔｅｉｎ :ＢＭＰ)属于生长转移因子 (Ｔｒａｎｓｆｏｒｍｉｎｇｇｒｏｗｔｈｆａｌｔｏｒβ)是属于ＴＧＦ—β的一种蛋白质 ,在机体内对骨组织具有特异性的诱导活性 ,且是与多种多样细胞的增殖、分化、基质产生等相关的多功能性因子。它在骨形态的形成及机体功能调节等方面具有重要的作用。1　ＢＭＰ的基础研究ＢＭＰ自被发现以来 ,国内外许多学者经过 30多年的研究 ,特别是最近的十年间 ,伴随着分子生物学技术的应用 ,已取得了显著成绩。1 1　ＢＭＰ的组成与种类Ｕｒｉｓｔ[3] 将经…     

胸腺修饰诱导同种异体静脉移植的免疫耐受研究

Objective To investigate the possibility of inducing immune tolerance to vein trans-plantation in rats by intrathymic injection of allogene. Methods MHC antigen extracted from splenic cells of donor Wistar rats was intrathymically injected to recipients SD rats, and donor Wistar femur vein was transplanted after 2 weeks. Forty-eight SD rats were randomly divided into 4 groups: group A ( femur vein autograft) ,group B ( femur vein allograft) ,group C ( femur vein allograft with use of immunosuppressant), group D (intrathymus injection). Imaging, histology and immunological assays of these groups were carried out 2 weeks after the transplantation. Results Histologic parameters that were tested were better in group D than those in group B. The concentration of serum IFN-γ in group B was significantly higher than that in groups A, C and D [ ( 86. 707±10.928 ) ng/L vs (29.328±4. 170), (69.076±8.059) and (63.355± 4.895) ng/L respectively, P < 0.05 ]. The concentration of serum IL-4 in group B was obviously lower than in groups C and D [ (23.656±3.369) ng/L vs (29.425±4.174) and ( 31.000±4.659) ng/L re-spectively,P < 0.05 ]. Conclusion Intrathymus injection of allogenic antigen might induce specific im-mune tolerance to femur vein transplantation in rats.     

纳络酮对全脑缺血大鼠的神经保护作用研究

全脑缺血后如何保护脑功能、减轻缺血/再灌注损伤是目前研究热点,但有效的神经保护剂并不多,仅tempol、MK-801等在实验中证明有效。纳络酮,作为传统意义的阿片受体拮抗剂,在许多实验和临床研究中亦被证明有神经保护作用,但仍存在较多争议。最近研究揭示纳络酮具有抑制钙超载的作用,本文通过研究其对钙结合蛋白表达的影响来探讨纳络酮的神经保护作用。1材料与方法实验选用健康SD大鼠29只,雌雄不拘,体重185.5～294.0g,建立窒息 艾司洛尔的大鼠心肺骤停模型[1],实验参数设计和记录均参照实验研究的Utstein模型。实验动物随机分为4组:假手术组…     

严重烧伤并发急性肾功衰竭死亡病例分析(附6例报告)

<正> 烧伤后急性肾功能哀竭(ARF)是烧伤早期严重并发症之一,死亡率极高。近两年来,我科有6名烧伤病人并发 ARF,均导致死亡,报告讨论如下。临床资料一、病例情况 1987年5月至1985年8月我利1收治的烧伤病人,},有6例并发了