碱性成纤维细胞生长因子促进大鼠硬腭穿孔的愈合

目的:研究碱性成纤维细胞生长因子 (bFGF)对硬腭穿孔愈合的影响。方法:在大鼠硬腭部制作早期硬腭穿孔动物模型,外用bFGF治疗硬腭穿孔。采用肉眼观察、病理学检查的方法进行评价。结果:肉眼观察发现bFGF组伤口愈合率明显高于对照组(P＜0.01); 病理学检查表明bFGF能刺激肉芽组织的增长,成纤维细胞分裂增殖; bFGF组成纤维细胞的核仁形成区嗜银蛋白颗粒数目为3.73±0.52,对照组为2.11±0.31(P＜0.05)。结论: bFGF有助于肉芽组织的生长,具有显著促进硬腭穿孔创伤愈合的作用,有助于硬腭穿孔的修复。     

一测多评法测定一清颗粒中5种蒽醌类成分的含量

目的:建立一清颗粒中5种主要活性成分的一测多评含量测定方法。方法:以大黄素为内标物,采用高效液相色谱法,建立其与其他4种成分芦荟大黄素、大黄酚、大黄素甲醚、大黄酸的相对校正因子,并用该校正因子进行计算,实现一测多评;同时采用外标法对5种成分进行含量测定,通过比较两法结果验证该方法的准确性。结果:建立的校正因子重复性较好,采用校正因子计算的含量值与外标法实测值偏差较小。结论:采用一测多评法测定一清颗粒中5种蒽醌类成分的含量是可行的。     

国产个性化舌侧矫治器治疗下颌牙列拥挤一例

舌侧矫治技术可满足有隐形矫治愿望者的要求.与以往传统舌侧矫治器相比,个性化舌侧矫治器的进步主要在于其引入了计算机辅助设计与辅助制作(computer aided design and computer aided manufacture,CAD-CAM)技术设计与制作矫治器,克服了传统舌侧矫治器的固有不足,有效解决了牙齿舌侧面形态多变致托槽易脱落、牙间距离窄小、托槽定位不准确、初始或重新粘接困难及精细调整阶段难度偏大等问题.     

99mTc-MDP放射性骨显像观察重组人骨形成蛋白-2与珊瑚人工骨修复牙槽骨缺损

目的：探讨应用^99mTc-MDP放射性骨显像观察重组人骨形成蛋白－2与珊瑚人工骨在牙槽骨缺损修复中成活和成骨效果的价值。方法：拔除12只成年狗两侧上颌第2及第3切牙，并去除牙槽窝之间的牙槽间隔，一侧随即植入复合骨，对侧植入珊瑚人工骨（珊瑚骨）作为对照。并与植入后4，8，12周取材，采用组织学观察、图像分析和^99mTc-MDP核素骨显像等方法比较两种植入材料在牙槽窝中的骨修复能力。结果：复合骨植入牙槽骨后，材料被逐渐降解吸收，新骨不断生成，12周后，植入材料完全被成熟的骨组织取代；图像分析结果显示不同时间复合骨组新骨形成的比值显著高于珊瑚骨组（P＜0．05）；4和8周复合骨组核素浓聚程度高于珊瑚骨组，12周两组核素浓聚程度差异不明显。结论：^99mTc-MDP放射性骨显像能早期判断移植骨的成活情况及成骨效果。     

应用锥形束CT评估腭部种植体的植入部位

Objective To investigate the vertical bone height and the bone density of the palate for implants placement using cone beam CT(CBCT)and to provide references to the safe and stable placement of palatal implants.Methods Three-dimensional reformatting images were reconstructed with the selected CBCT scanning data of 34 patients aged 18 to 35 yeras,by means of EZ implant software.The vertical bone height was measured at 20 interesting sites of palate.Bone density was measured at 10 sites that could support 3.0mm long implants.The data of the vertical bone height and bone density were analyzed by Kmeans cluster analysis.Results According to the cluster analysis results,the 10 sites were classified into 3 clusters.There were statistical differences among these three clusters in bone height and bone density(P＜0.05).The ISD result showed that the greatest mean value of vertical bone height was obtained in cluster 2,followed by cluster 1 and cluster 3;the highest bone density was founded in cluster 3,followed by cluster 1 and cluster 2.Conclusions Evaluation of the sites for palatal implant placement with cone beam CT would be helpful in safe and stable implantation.     

应用锥形束CT评估腭部种植体的植入部位

Objective To investigate the vertical bone height and the bone density of the palate for implants placement using cone beam CT(CBCT)and to provide references to the safe and stable placement of palatal implants.Methods Three-dimensional reformatting images were reconstructed with the selected CBCT scanning data of 34 patients aged 18 to 35 yeras,by means of EZ implant software.The vertical bone height was measured at 20 interesting sites of palate.Bone density was measured at 10 sites that could support 3.0mm long implants.The data of the vertical bone height and bone density were analyzed by Kmeans cluster analysis.Results According to the cluster analysis results,the 10 sites were classified into 3 clusters.There were statistical differences among these three clusters in bone height and bone density(P＜0.05).The ISD result showed that the greatest mean value of vertical bone height was obtained in cluster 2,followed by cluster 1 and cluster 3;the highest bone density was founded in cluster 3,followed by cluster 1 and cluster 2.Conclusions Evaluation of the sites for palatal implant placement with cone beam CT would be helpful in safe and stable implantation.     

影响微螺钉种植体植入效果的上颌骨解剖研究

目的　研究上颌第二前磨牙与第一磨牙牙根间植入的微螺钉种植体与上颌窦的关系及其周围骨质密度值，为临床上植入微螺钉种植体的安全性与稳定性提供参考。方法　在重建后的CBCT影像上测量上颌第二前磨牙与第一磨牙牙根间矢状面上16个部位的颊舌侧骨质厚度，计算各植入部位触及上颌窦的危险率，在骨厚度大于6.0mm的植入部位模拟植入微螺钉种植体并测量其周围骨质密度。结果　① 16.0mm和14.0mm、12.0mm三个高度组中均以30°植入的微螺钉种植体周围骨密度值最大（P<0.05）。②植入部位可分3类，其中，2类植入部位的危险率和骨密度值最大，1类植入部位的危险率和骨密度值最小，3类植入部位的危险率和骨密度值介于1类与2类之间。结论　①如果可以确保微螺钉种植体植入安全的情况下，当临床以12.0mm、14.0mm或16.0mm高度植入微螺钉种植体时，建议与骨皮质表面成30°植入以利于提高微螺钉种植体的稳定性。②如果未知微螺钉种植体植入是否安全，建议选安全性最好的1类部位。     

内收前牙时微种植钉调控牙合平面的有限元分析

目的:探讨内收上前牙过程中,前牙区不同大小压低力对上颌平面变化的影响.方法:应用CBCT扫描、MIMICS以及ANSYS等软件建立微种植钉内收前牙的三维有限元模型,设置前牙区分别为0、0.5、0.75、1 N的压低力,计算分析前后牙的位移趋势以及平面的变化.结果:单纯的内收力使上前牙舌倾、第一磨牙远中倾斜、上颌平面顺时针旋转.随着前牙区压低力增大,上前牙舌倾程度降低,接近整体移动,第一磨牙远中倾斜移动的趋势减小,平面顺时针旋转的情况得以抑制.结论:通过改变前牙区压低力的大小,可以有效地改变上颌前牙的移动方式及平面的旋转;在内收前牙时增加0.5~0.75 N压低力,更有利于防止上颌平面的顺时针旋转.     

应用锥形束CT评估腭部种植体的植入部位

Objective To investigate the vertical bone height and the bone density of the palate for implants placement using cone beam CT(CBCT)and to provide references to the safe and stable placement of palatal implants.Methods Three-dimensional reformatting images were reconstructed with the selected CBCT scanning data of 34 patients aged 18 to 35 yeras,by means of EZ implant software.The vertical bone height was measured at 20 interesting sites of palate.Bone density was measured at 10 sites that could support 3.0mm long implants.The data of the vertical bone height and bone density were analyzed by Kmeans cluster analysis.Results According to the cluster analysis results,the 10 sites were classified into 3 clusters.There were statistical differences among these three clusters in bone height and bone density(P＜0.05).The ISD result showed that the greatest mean value of vertical bone height was obtained in cluster 2,followed by cluster 1 and cluster 3;the highest bone density was founded in cluster 3,followed by cluster 1 and cluster 2.Conclusions Evaluation of the sites for palatal implant placement with cone beam CT would be helpful in safe and stable implantation.     

成年人上前牙列拥挤的牙外科正畸术

成人牙外科正畸术中,中重度前牙到拥挤被认为是禁忌症之一。其原因是:在牙与牙分开过程中,容易损伤牙根及粘骨膜,造成牙齿甚至骨块坏死。因此,如何能将拥挤牙齿分开,保护好粘骨膜,是解决中重度牙列拥挤外科正畸术的关键。我科共收治9例此类患者,效果满意,现将其报告如下: