中药固体炮制辅料探源

中药固体炮制辅料探源唐永明①赵秋蕊②传统上，习惯于把中药炮制工作归纳为“水制”、“火制”、和“水火共制”三类。本文所讨论的中药固体炮制辅料（以下简称“辅料”），乃是专指参与“火制”过程的各种固体物质。作为辅料，除极少数外，一般都在炮制结束时被弃去不用...     

白细胞清除术辅助治疗高白细胞白血病15例

目的：观察白细胞清除术治疗高白细胞白血病的临床疗效。方法：连续流动性血细胞分离机循环分离血液，去除白细胞辅助治疗白血病共15例，其中髓系白血病组9例，淋系白血病组6例，并观察治疗前后外周血Hb,WBC,Plt值及临床症状的变化。结果：治疗后所有患者外周血白细胞数显著下降，临床症状明显好转。结论：白细胞清除术在高白细胞白血病的治疗中有独特的应用价值。     

Study on Distribution of HFRS Virus in the Tissuses and Cells of Human Body

Immunochemical rnethods,viral tissue culture and dlectron microscopic observationtechiniques were used to study the distribution of HFRS virus in the tissues and cells of patients withHFRS and sorne of their abotive faus.The results showed that HFRS virus could infect many hu-man organs and cells and pass through plaoenta and blood-brain barrier,and was characteristic ofpantropical infection,the duration of the viremia of the patients being mostly near a week.Thestudy is valuable for elucidation pathogenesis of the disease.     

中国非小细胞肺癌患者血清DAPK基因、p16基因启动子甲基化的分析

Objective： To evaluate the clinical significance of the aberrant methylation of DAPK gene and p16 gene in sera from 65 NSCLC patients from Nanjing General Hospital of Nanjing Command, China. Methods： A methylation-specific PCR （MSP） was performed for the detection of promoter hypermethylation of DAPK gene and p16 gene in blood DNA from 65 cases of NSCLC, and to analyze the relation of the aberrant methylation of DAPK gene and p16 gene and the clinicopathological data. Results： 30.8% （20/65） of the sera from 65 cases of NSCLC showed hypermethylation for DAPK promoter and 43.1% （28/65） the same for p16 promoter, whereas no methylated DAPK gene promoter and p16 gene promoter were found in sera from the patients with lung benign diseases and normal controls. Methylated DAPK gene promoter and p16 gene promoter in sera were not closely correlated with the pathological classification, stage, metastasis and differentiation in NSCLC. Conclusion： Detection of the aberrant methylation of DAPK gene and p16 gene in blood DNA from NSCLC patients might offer an effective means for the earlier auxiliary diagnosis of the malignancy.     

中国非小细胞肺癌患者血清DAPK基因、p16基因启动子甲基化的分析(英文)

目的分析65名中国南京军区南京总医院的非小细胞肺癌(NSCLC)住院患者血清中DAPK、p16启动子区域甲基化的改变状况及其临床意义。方法运用甲基化特异性PCR技术,检测65例NSCLC患者血清DAPK、p16基因启动子区域甲基化的改变情况,并分析与临床病理资料的关系。结果 NSCLC患者血清DAPK基因甲基化检出率为30．8％(20/65),p16基因甲基化检出率为43．1％(28/65),而正常对照组和良性肺部疾病组血清未检出DAPK基因、p16基因甲基化,DAPK基因、p16基因甲基化检出率与NSCLC病理类型、分期及转移状态无明显关系。结论 DAPK基因、p16基因检出启动子区域异常甲基化是NSCLC早期辅助诊断的分子标志物之一。     

脑卒中患者早期康复治疗的临床效果探析

目的分析病发脑卒中的患者应用基于早期康复理念治疗方案的临床效果。方法选取青海省大通回族土族自治县人民医院急诊科收治的病发脑卒中的患者共计98例,并按照随机电脑等量法的分组原则进行规范化处理,每组各纳入患者49例。在疾病治疗过程中,对照组纳入患者配合开展常规康复治疗,实验组纳入患者在对照组治疗基础上采取早期康复治疗。密切观察两组的临床效果,并比较其治疗前后的Fugl-Meyer评分与Barthel指数的变化情况。结果治疗活动开始前,两组的Fugl-Meyer评分、Barthel指数均无统计学意义(P>0.05);治疗活动开展后,两组的Fugl-Meyer评分、Barthel指数均发生了明显变化,且实验组显著具有更高水平(P<0.05)。结论对病发脑卒中的患者应用基于早期康复理念的治疗方案具有显著疗效,明显改善患者运动功能的同时,还能有效提高患者日常生活自理能力,积极促进预后转归。