Neutrophil CD64: diagnostic accuracy and prognostic value in patients presenting to the emergency department

The purpose of this study was to evaluate the diagnostic accuracy and prognostic value of neutrophil CD64 expression for bacterial infection in febrile adult patients presenting to our hospital emergency department. We prospectively included 132 patients with fever ??8oC (??00.4oF) during the last 24 hours and we measured CD64 expression on neutrophils the day after admission at the emergency department. We followed the patients until full recovery or death. There were 115 (87%) patients with bacterial infection and 108 (94%) of them survived. There were 17 (13%) patients without bacterial infection and 12 (71%) of them survived. Patients with bacterial infection and patients who survived showed a CD64 index higher when compared with patients without bacterial infection and patients who died, respectively (3.7?±??.2 vs. 2.5?±??.3; p??/em>=??.03; and 3.7?±??.1 vs. 1.7?±??.6; p?????.002; Mann-Whitney U test). The receiver operating characteristic (ROC) curve analysis for detecting bacterial infection and predicting survival with the CD64 index showed an area under curve (AUC) of 0.66 (95% CI, 0.52??.8; p????.03) and 0.71 (95% CI, 0.57??.85; p??/em>=??.01), respectively. Diagnostic accuracy and prognostic value of CD64 expression was good in adult patients with fever.     

Visceral Larva Migrans in Immigrants from Latin America

To determine whether increased migration is associated with an increase in incidence of toxocariasis (visceral larva migrans), we analyzed clinical data obtained from immigrants from Latin America. Although infection with Toxocara sp. roundworm larvae is distributed worldwide, seroprevalence is highest in tropical and subtropical areas.     

Nutzen- und Wirtschaftlichkeitsbewertung der biomedizinischen Technik

Medical devices cover a wide spectrum of products with very different diagnostic and therapeutic applications. However, for market licensing, uniform rules apply. Uniform rules are also valid for coverage decisions in German health care. In this article, the criteria for the assessment of benefit and efficiency of innovative biomedical technologies are described from the perspective of the statutory health insurance system. The key concepts relevant in the mandatory health insurance? ??innovation??? ??benefit??, and ??economic efficiency?? are characterized. Only measurable effects of an intervention which lead to a more than marginal improvement in prognosis, symptoms, or quality of life as compared to a standard treatment are considered as beneficial. An innovative device is, therefore, subject to a benefit assessment if it is not yet reimbursed (or not yet part of the benefit package), when it is relevant to the health care system and a high public interest exists. In addition, it is important to consider a positive benefit assessment as a part of the value added chain to avoid conflicts of interest. Within the scope of early technology assessment, some conclusions can already be drawn in the early developmental stage of a device.     

Molecular mechanism of pancreatic cancer��understanding proliferation, invasion, and metastasis

Introduction  

The purpose of this review is to highlight the molecular mechanisms leading to the development and progression of pancreatic ductal adenocarcinoma (PDAC) with particular emphasis on tumor cell proliferation, local invasion, and metastasis. Recent advances in the field of PDAC biology have shed light on the molecular events that trigger PDAC initiation and maintenance.     

Gene�Cgene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women

Summary  

We have analysed the association of single-nucleotide polymorphisms (SNPs) in CD40 and CD40L genes with bone mineral density (BMD) in our women. Results showed that women with TT genotype for rs1883832 (CD40) and for rs1126535 (CD40L) SNPs displayed reduced BMD and increased risk for osteopenia/osteoporosis. Our data notwithstanding, the results need to be replicated.     

Fibromuskul?re Dysplasie und akuter Herztod

In the present review fibromuscular dysplasia (FMD) is presented from a forensic medical point of view. Every artery can be affected by FMD including the aorta and can occur simultaneously either isolated or in different arteries. The symptoms and consequences of FMD depend on the localization and the severity of the arterial wall changes. While FMD of the renal arteries and the cervical arteries has substantial relevance in clinical practice, forensic pathologists who examine sudden unexpected deaths, observe FMD more frequently in arteries of the heart. There are several case reports in the literature whereby FMD of the atrioventricular (av) node artery is most frequently mentioned in connection with the cause of death.     

Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells

Recent studies with human embryonic stem (hES) cells have established new protocols for substantial generation of pancreatic progenitors from definitive endoderm. These findings add to the efficient derivation of definitive endoderm, which is controlled by Wnt and Nodal pathways, and delineate a step forward in the quest for alternative β-cell sources. It also indicates that critical refining of the available strategies might help define a universal protocol for pancreatic differentiation applicable to several cell lines, therefore offering the possibility for transplantation of immune-matched or patient-specific hES–derived β-cells. We appraise here the fundamental role that bone morphogenetic protein, fibroblast growth factor, and retinoid signaling play during pancreas development, and describe a fundamental emergence of their combination in recent studies that generated pancreatic cells from hES cells. We finally enumerate some prospects that might improve further differentiation of the progenitor cells into functional β-cells needed in diabetes cell therapy.