全文获取类型
收费全文 | 402篇 |
免费 | 23篇 |
国内免费 | 64篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 22篇 |
妇产科学 | 4篇 |
基础医学 | 59篇 |
口腔科学 | 7篇 |
临床医学 | 73篇 |
内科学 | 78篇 |
皮肤病学 | 9篇 |
神经病学 | 15篇 |
特种医学 | 85篇 |
外科学 | 27篇 |
综合类 | 22篇 |
预防医学 | 13篇 |
眼科学 | 6篇 |
药学 | 47篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2021年 | 9篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 11篇 |
2014年 | 8篇 |
2013年 | 12篇 |
2012年 | 9篇 |
2011年 | 8篇 |
2010年 | 14篇 |
2009年 | 24篇 |
2008年 | 5篇 |
2007年 | 45篇 |
2006年 | 14篇 |
2005年 | 15篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 28篇 |
1997年 | 37篇 |
1996年 | 26篇 |
1995年 | 22篇 |
1994年 | 12篇 |
1993年 | 24篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 19篇 |
1988年 | 7篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 8篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 12篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1971年 | 2篇 |
1969年 | 1篇 |
1966年 | 1篇 |
1960年 | 1篇 |
1959年 | 1篇 |
1903年 | 1篇 |
排序方式: 共有489条查询结果,搜索用时 78 毫秒
81.
One hundred fifty-one consecutive patients scheduled for double-contrast barium enema studies were assigned randomly to insufflation with either air or carbon dioxide (CO2) in a double-blind, prospective trial. Within 24 hours after the enema study, the patients were contacted by telephone by an interviewer, who completed a standard questionnaire. Radiographs from the enema studies were assessed for quality by two radiologists. Pain experienced after the procedure was graded from 0 (none) to 4 (severe). Clinically relevant (grades 2-4) pain was experienced by 30% of patients after insufflation with room air, compared with 11% of patients in whom CO2 was used for insufflation (P = .005). The mean pain score for CO2 was 0.4, and for room air, 1.2 (P less than .005). Although five patients experienced grade 4 pain after insufflation with air, no patient reported severe pain after CO2 insufflation. Post-evacuation films confirmed there was significantly less residual gas in the CO2 group. The quality of radiographs was equal in the two groups. CO2 has advantages for use in the double-contrast barium enema examination. 相似文献
82.
83.
84.
85.
86.
87.
88.
89.
JC McGrath GB Drummond EM McLachlan C Kilkenny CL Wainwright 《British journal of pharmacology》2010,160(7):1573-1576
British Journal of Pharmacology (BJP) is pleased to publish a new set of guidelines for reporting research involving animals, simultaneously with several other journals; the ‘ARRIVE’ guidelines (Animals in Research: Reporting In Vivo Experiments). This editorial summarizes the background to the guidelines, gives our view of their significance, considers aspects of specific relevance to pharmacology, re-states BJP''s guidelines for authors on animal experiments and indicates our commitment to carrying on discussion of this important topic. We also invite feedback via the British Pharmacological Society website. 相似文献
90.
Szodoray P Nakken B Barath S Gaal J Aleksza M Zeher M Sipka S Szilagyi A Zold E Szegedi G Bodolay E 《International immunology》2008,20(8):971-979
The objectives of the study is to determine clinical signs and distribution of peripheral T-cell subsets, B cells and T regulatory cells in patients with undifferentiated connective tissue disease (UCTD) and during the development toward well-established connective tissue diseases (CTD). The methods include 46 patients with UCTD were followed and investigated for differentiation into defined CTDs for 2 years. Cell subsets were determined on the basis of cell surface markers, intracellular cytokine production by flow cytometry and serum cytokine levels by ELISA. The results are as follows: 45.6% of UCTD patients developed into a defined CTD. The number and percentage of activated T cells, memory T cells and NKT cells were increased in patients compared with controls. In addition, in patients with UCTD, the percentage of CD4+/IFN gamma+ T(h)1 was significantly higher compared with controls and further increased in patients that developed CTDs. The percentage and absolute number of CD4+CD25+Foxp3+ regulatory T cells (Tregs) were diminished in UCTD patients compared with healthy controls, while the number of CD4+/IL-10+ Tregs increased. The conclusions are Overproduction of IFN gamma and the decrease of natural (Foxp3+) Tregs seem to be characteristic features of UCTD patients. The increased IL-10 production of CD4+ T cells might be a compensatory suppressive mechanism; however, it is probably not able to balance the overproduction of IFN gamma and the observed decrease of Foxp3+ Tregs. The shift toward T(h)1 with increased IFN gamma production in patients with UCTD combined with the degree of immunoregulatory disturbances characterized by the progressive divergent shifts in natural and induced T-regulatory cell populations signify the transition from undifferentiated to definitive CTD. 相似文献